Zobrazeno 1 - 10
of 277
pro vyhledávání: '"Peter H. Sugden"'
Autor:
Hajed O. Alharbi, Michelle A. Hardyman, Joshua J. Cull, Thomais Markou, Susanna T.E. Cooper, Peter E. Glennon, Stephen J. Fuller, Peter H. Sugden, Angela Clerk
Cardiac hypertrophy is necessary for the heart to accommodate an increase in workload. Physiological, compensated hypertrophy (e.g. with exercise) is reversible and largely due to cardiomyocyte hypertrophy. Pathological hypertrophy (e.g. with hyperte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cac2dcbbe2f252857669529379968100
https://doi.org/10.1101/2022.09.07.506723
https://doi.org/10.1101/2022.09.07.506723
Autor:
Angela Clerk, Peter H. Sugden
Publikováno v:
Bioscience reports. 42(7)
Insulin was discovered over 100 years ago. Whilst the first half century defined many of the physiological effects of insulin, the second emphasised the mechanisms by which it elicits these effects, implicating a vast array of G proteins and their re
Autor:
Daniel N. Meijles, Susanna T. E. Cooper, Peter E. Glennon, John Sembrat, Spencer Shaw, Leanne E. Felkin, Angela Clerk, Mauricio Rojas, Peter H. Sugden, Thomais Markou, Sam J. Leonard, M. N. Sheppard, K. Vanezis, Michelle A. Hardyman, Owen J. L. Rackham, Joshua J Cull, Paul J.R. Barton, Charles F. McTiernan, S A Cook, Sonia Chothani, Stephen J. Fuller, Hajed O. Alharbi
The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade promotes cardiomyocyte hypertrophy and is cardioprotective, with the three RAF kinases forming a node for signal integration. Our aims were to determine if BRAF is relevant for human hear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::121752225409a1c8d37392fa7f2ed3a0
https://doi.org/10.1101/2021.08.14.455637
https://doi.org/10.1101/2021.08.14.455637
Autor:
Angela Clerk, Daniel N. Meijles, Michelle A. Hardyman, Stephen J. Fuller, Sonia P. Chothani, Joshua J. Cull, Susanna T.E. Cooper, Hajed O. Alharbi, Konstantinos Vanezis, Leanne E. Felkin, Thomais Markou, Samuel J. Leonard, Spencer W. Shaw, Owen J.L. Rackham, Stuart A. Cook, Peter E. Glennon, Mary N. Sheppard, John C. Sembrat, Mauricio Rojas, Charles F. McTiernan, Paul J. Barton, Peter H. Sugden
Publikováno v:
The Biochemical journal. 479(3)
The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade promotes cardiomyocyte hypertrophy and is cardioprotective, with the three RAF kinases forming a node for signal integration. Our aims were to determine if BRAF is relevant for human hear
Autor:
Daniel N. Meijles, Hajed O. Alharbi, Angela Clerk, Michelle A. Hardyman, Peter H. Sugden, Liam J. McGuffin, Joshua J Cull, Stephen J. Fuller, Nick S. Edmunds
Publikováno v:
Biochemical Journal
The Ser/Thr kinase MAP4K4, like other GCKIV kinases, has N-terminal kinase and C-terminal citron homology (CNH) domains. MAP4K4 can activate c-Jun N-terminal kinases (JNKs), and studies in the heart suggest it links oxidative stress to JNKs and heart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0258562b3a1847fd2244ac3a4af309a6
https://openaccess.sgul.ac.uk/id/eprint/113385/1/bcj-2021-0003.pdf
https://openaccess.sgul.ac.uk/id/eprint/113385/1/bcj-2021-0003.pdf
Autor:
Susanna T. E. Cooper, Angela Clerk, Stephen J. Fuller, Joshua J Cull, Hajed O. Alharbi, Peter H. Sugden, Daniel N. Meijles
Publikováno v:
Biochemical Journal
Insulin and insulin-like growth factor stimulate protein synthesis and cardioprotection in the heart, acting through their receptors (INSRs, IGF1Rs) and signalling via protein kinase B (PKB, also known as Akt). Protein synthesis is increased in heart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5aeefe6e4ed0e769ba7ee2049de61e
https://openaccess.sgul.ac.uk/id/eprint/113355/1/bcj-2021-0144.pdf
https://openaccess.sgul.ac.uk/id/eprint/113355/1/bcj-2021-0144.pdf
Autor:
Daniel N. Meijles, Angela Clerk, Feroz Ahmad, Susanna T. E. Cooper, Peter H. Sugden, Zoe Haines, Stephen J. Fuller, Hajed O. Alharbi, Joshua J Cull, Viridiana Alcantara Alonso
Publikováno v:
Circulation. 142
Introduction: Epidermal growth factor (EGF) receptors (EGFRs: ERBB1-4) are activated by a family of ligands (e.g. EGF, Hb-EGF, EREG, TGFa), signaling through ERK1/2 and Akt to promote cell division and cancer. Antibody-based inhibition of ERBB2 in br
The function of the heart is to provide the tissues of the body with sufficient oxygenated blood and metabolites to meet the moment-to-moment needs as dictated by physical activity and postural and emotional changes. Cardiac myocytes are the contract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395459fa49abee1b7fd235468736e94d
https://doi.org/10.1093/med/9780198746690.003.0339
https://doi.org/10.1093/med/9780198746690.003.0339
Autor:
Andrew K Marshall, Oliver P T Barrett, Timothy E Cullingford, Achchuthan Shanmugasundram, Peter H Sugden, Angela Clerk
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10027 (2010)
Cardiomyocyte hypertrophy is associated with changes in gene expression. Extracellular signal-regulated kinases 1/2 (ERK1/2) and RhoA [activated by hypertrophic agonists (e.g. endothelin-1)] regulate gene expression and are implicated in the response
Externí odkaz:
https://doaj.org/article/a5f889d6a8db46e181196577e51151c9
Publikováno v:
Circulation Research. 123
Introduction: Raf kinases lie upstream of ERK1/2 with BRaf having the highest activity. ERK1/2 promote hypertrophy/cardioprotection, but the role of BRaf in the adult heart is unclear. BRaf mutations cause cancer and Raf inhibitors (Rafi) are used bu