Výsledky vyhledávání - "Peter H. Hutson"

Binge-eating disorder: Clinical and therapeutic advances

Autor: Iris M. Balodis, Peter H. Hutson, Marc N. Potenza

Publikováno v: Pharmacologytherapeutics. 182

Binge-eating disorder (BED) is the most prevalent eating disorder with estimates of 2-5% of the general adult population. Nonetheless, its pathophysiology is poorly understood. Furthermore, there exist few therapeutic options for its effective treatm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0cc727c5f5abb9e5e6892be35b605b
https://pubmed.ncbi.nlm.nih.gov/28830840

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Dopamine and μ-opioid receptor dysregulation in the brains of binge-eating female rats - possible relevance in the psychopathology and treatment of binge-eating disorder

Autor: Jane Gosden, Michelle Hallam, M. R. Prow, Peter H. Hutson, David J. Heal, Frank I. Tarazi, Sharon C. Cheetham, Yong K Choi

Publikováno v: Journal of psychopharmacology (Oxford, England). 31(6)

Adult, female rats given irregular, limited access to chocolate develop binge-eating behaviour with normal bodyweight and compulsive/perseverative and impulsive behaviours similar to those in binge-eating disorder. We investigated whether (a) dysregu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adfc2ad0616669d0faba1ec67df50b21
https://pubmed.ncbi.nlm.nih.gov/28376679

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Investigation of impulsivity in binge-eating rats in a delay-discounting task and its prevention by the d-amphetamine prodrug, lisdexamfetamine

Autor: Richard J Brammer, Peter H. Hutson, Steven P Vickers, David J. Heal, Simon Goddard

Publikováno v: Journal of psychopharmacology (Oxford, England). 31(6)

Freely-fed, female, rats were trained in a two-lever, delay-discounting task: one lever delivered a single chocolate-flavoured pellet immediately and the other a three-pellet reward after increasing delay (0, 4, 8, 16, 32 s). Rats were divided into t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8950a8709bdae303d915b57024f1eb4c
https://pubmed.ncbi.nlm.nih.gov/28372478

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Mechanism based neurotoxicity of mGlu5 positive allosteric modulators – Development challenges for a promising novel antipsychotic target

Publikováno v: Neuropharmacology. 82:161-173

Previous work has suggested that activation of mGlu5 receptor augments NMDA receptor function and thereby may constitute a rational approach addressing glutamate hypofunction in schizophrenia and a target for novel antipsychotic drug development. Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44024f123a60505445bf06fd0e251b96
https://doi.org/10.1016/j.neuropharm.2012.12.003

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The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents

Publikováno v: Neuropharmacology. 61:665-676

Inhibition of phosphodiesterase 9 (PDE9) has been reported to enhance rodent cognitive function and may represent a potential novel approach to improving cognitive dysfunction in Alzheimer’s disease. PF-04447943, (6-[(3 S ,4 S )-4-methyl-1-(pyrimid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa52ce166292113db2ec4badc538492
https://doi.org/10.1016/j.neuropharm.2011.05.009

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Effects on sleep stages and microarchitecture of caffeine and its combination with zolpidem or trazodone in healthy volunteers

Autor: David J. Nutt, Magnus Ivarsson, Peter H. Hutson, Stephen J. Wilson, L.M. Paterson

Publikováno v: Journal of Psychopharmacology. 23:487-494

Abstract Caffeine is the world’s most popular stimulant and is known to disrupt sleep. Administration of caffeine can therefore be used in healthy volunteers to mimic the effects of insomnia and thus to test the hypnotic effects of medication. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb07dc9ddc641bdffc910b7d3f885f3d
https://doi.org/10.1177/0269881109104852

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Differential effects of MPEP and diazepam in tests of conditioned emotional response and Pavlovian-to-instrumental transfer suggests ‘anxiolytic’ effects are mediated by different mechanisms

Autor: Peter H. Hutson, Sophie A. George, David N. Stephens

Publikováno v: Psychopharmacology. 204:499-509

The selective mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) is reported to be anxiolytic in several animal models of anxiety, including the conditioned emotional response (CER) paradigm. Suppression of responding during conditioned sti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2e215528432797b27405de450e3395
https://doi.org/10.1007/s00213-009-1479-6

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A translational, caffeine-induced model of onset insomnia in rats and healthy volunteers

Autor: L.M. Paterson, David J. Nutt, Sue Wilson, Magnus Ivarsson, Peter H. Hutson

Publikováno v: Psychopharmacology. 191:943-950

Insomnia is a common and disabling complaint for which there is a need for improved treatments. Successful drug discovery relies on the use of appropriate animal models to assess likely outcome in the clinic. The purpose of this study was to develop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28cf15032cf00ff640983064960b423c
https://doi.org/10.1007/s00213-006-0672-0

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