Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Peter H. Duesberg"'
Autor:
Mathew Bloomfield, Peter H. Duesberg
Publikováno v:
Molecular Cytogenetics, Vol 11, Iss 1, Pp 1-16 (2018)
Molecular Cytogenetics
Molecular Cytogenetics
Background Foulds defined, “Tumor progression (as a) permanent, irreversible qualitative change in one or more of its characters” (Cancer Res. 1954). Accordingly progressions, such as metastases and acquired drug-resistance, were since found to b
Publikováno v:
Genes, Vol 9, Iss 8, p 402 (2018)
Genes
Volume 9
Issue 8
Genes
Volume 9
Issue 8
It has been known for over 100 years that cancers have individual karyotypes and arise only years to decades after initiating carcinogens. However, there is still no coherent theory to explain these definitive characteristics of cancer. The prevailin
Autor:
J. Xu, N. Page, Ruediger Hehlmann, Marthe Løvf, Victor Guryev, Sarah Grasedieck, J. Stein, Paola Cavaliere, Diana C.J. Spierings, S. Bhattacharya, Caroline Jansson, Allan Bradley, Andrew L. Trinh, Zuzana Storchova, Mat Bloomfield, G. Stein, Tristan V. de Jong, Nicolaas C. Baudoin, Jonas M. SveeStrømme, H. Ding, J. Vecerova, Xue Gong, Christina Raftopoulou, Nancy Halsema, Nataliya Huleyuk, Rolf Inge Skotheim, Jordi Camps, Mathew Bloomfield, Christof Börgermann, Anita Sveen, Steven Horne, Bjarne Johannessen, Julian Swoboda, Vladimir P. Baklaushev, A. Fritz, Anders Valind, N. Donnelly, Henry H.Q. Heng, Aracelli Acevedo-Colina, Peter H. Duesberg, A. A. Stepanenko, Rainer Engers, C. Kruse, Mark D. Vincent, Yi-Hong Zhou, Lars Bullinger, Sunyoung Hwang, Fani-Marlen Roumelioti, Vladimir P. Chekhonin, R. Berezney, Martha R. Stampfer, Batoul Y. Abdallah, Guo Liu, C. Tye, David Porubsky, Jenny Karlsson, James C. Garbe, Verena Passerini, Oksana A. Kovaleva, Xinhe Huang, Andrej Schevchenko, N. Sehgal, Frank G. Rücker, Milena Dürrbaum, Karina Hoekstra-Wakker, Daniela Cimini, David Gisselsson, Ellen K. Silbergeld, Stanislav Avdieiev, Bianca Habermann, S V Andreieva, Anke van den Berg, Hans Tobias Gustafsson, Daniele Mandrioli, Jonathan R. Pollack, A. Voskanyan, Floris Foijer, Josef Dietz, Thomas Liehr, Stefan Biesterfeld, Athel Cornish-Bowden, Melissa J. Perry, Fiorella Belpoggi, Christine J. Ye, B. Stojkovicz, Lukas Vrba, Peter M. Lansdorp, Maria Colomé Tatché, Ciara O’Sullivan, Ragnhild A. Lothe, Mirjam E. Belderbos, Hinke G. Kazemier, Eveline S. J. M. de Bont, Kateryna Korets, Alfred Böcking, David Rasnick, Joshua M. Nicholson, Michelle A. Digman, Isabel Quintanilla, Sen Zhao, Yegor S. Vassetzky, Jennifer A. Marshall Graves, Bernard W. Futscher, Mark A. LaBarge, Aaron Taudt, Leonid Berynskyy, Maria Chiourea, Robert C. Dickson, Dmytro Mykytenko, Andreas M. Hoff, Noah Dephoure, C. Marcelo Aldaz, Bjorn Bakker, Christian Klose, Sarantis Gagos, Alice Fabarius, Eduardo M. Torres, Kimberly Soto
Publikováno v:
Molecular Cytogenetics. 10
Author(s): Cornish-Bowden, Athel; Cornish-Bowden, Athel; Rasnick, David; Heng, Henry H; Horne, Steven; Abdallah, Batoul; Liu, Guo; Ye, Christine J; Bloomfield, Mathew; Vincent, Mark D; Aldaz, C Marcelo; Karlsson, Jenny; Valind, Anders; Jansson, Carol
Autor:
Mathew Bloomfield, Peter H. Duesberg
Publikováno v:
Molecular Cytogenetics
Background The genetic basis of metastasis is still unclear because metastases carry individual karyotypes and phenotypes, rather than consistent mutations, and are rare compared to conventional mutation. There is however correlative evidence that me
Autor:
Amanda McCormack, Peter H. Duesberg
Publikováno v:
Cell Cycle. 12:783-802
Immortality is a common characteristic of cancers, but its origin and purpose are still unclear. Here we advance a karyotypic theory of immortality based on the theory that carcinogenesis is a form of speciation. Accordingly, cancers are generated fr
Autor:
Christine A. Iacobuzio-Donahue, Amanda McCormack, Peter H. Duesberg, Jacqueline A. Brosnan, Lewis Chen, Daniele Mandrioli
Publikováno v:
Cell Cycle. 11:1151-1166
Conventional mutation theories do not explain (1) why the karyotypes of metastases are related to those of parental cancers but not to those of metastases of other cancers and (2) why cancers metastasize at rates that often far exceed those of conven
Publikováno v:
Cell Cycle. 10:2100-2114
Since cancers have individual clonal karyotypes, are immortal and evolve from normal cells treated by carcinogens only after exceedingly long latencies of many months to decades-we deduce that carcinogenesis may be a form of speciation. This theory p
Autor:
Adolf Graessmann, Andreas Klein, Peter H. Duesberg, Nan Li, Joshua M. Nicholson, Amanda McCormack
Publikováno v:
Cancer Genetics and Cytogenetics. 200:79-99
Cancers are clones of autonomous cells defined by individual karyotypes, much like species. Despite such karyotypic evidence for causality, three to six synergistic mutations, termed onco- genes, are generally thought to cause cancer. To test single
Publikováno v:
Cancer Genetics and Cytogenetics. 180:89-99
Several researchers, including us, have recently proposed that specific karyotypes, rather than specific mutations, generate the "biochemical individuality" of cancers, defined by individual growth rates, metabolisms, drug-resistances, metastases and
Autor:
Michelle Giehl, Peter H. Duesberg, Riidiger Hehlmann, Birgit Spiess, Chun Zheng, Wolfgang Seifarth, Martin Müller, Andreas Hochhaus, Christel Weiss, Alice Fabarius, Oliver Frank
Publikováno v:
British Journal of Haematology. 138:369-373
Summary Centrosomes play fundamental roles in mitotic spindle organisation, chromosome segregation and maintenance of genetic stability. Recently, we have demonstrated that the tyrosine kinase inhibitor imatinib induces centrosome and chromosome aber