Výsledky vyhledávání - "Peter H Levine"

Bone Marrow Stromal Cell-Mediated Gene Therapy for Hemophilia A: In Vitro Expression of Human Factor VIII with High Biological Activity Requires the Inclusion of the Proteolytic Site at Amino Acid 1648

Autor: Van Cherington, Joyce Sobolewski, Hillard L. Rubin, Joel S. Greenberger, Anita Gaffney, Ti Wang, Claire A. Mcgrath, Peter H Levine, Shahin Emami, Gisela G. Chiang, Nava Sarver, David R. Hurwitz

Publikováno v: Human Gene Therapy. 10:61-76

To evaluate the potential of the ex vivo bone marrow stromal cell (BMSC) system as a gene therapy for hemophilia A, we studied the in vitro expression of human factor VIII (hFVIII) in canine BMSCs following transfection with plasmid vectors and trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b938da1228c08980f881e06ecdd9e96
https://doi.org/10.1089/10430349950019192

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Enhanced growth of canine bone marrow stromal cell cultures in the presence of acidic fibroblast growth factor and heparin

Autor: Michael J. Hansen, Michael Kirchgesser, Wilma Merrill, Gisela G. Chiang, Shahin Emami, Van Cherington, David R. Hurwitz, Joel S. Greenberger, Peter H Levine, Joseph M. Appel

Publikováno v: In Vitro Cellular & Developmental Biology - Animal. 33:503-511

The ex vivo establishment, expansion, transduction, and reintroduction of autologous bone marrow stromal cells offers a potential efficacious system for somatic cell gene therapy. It is likely that any ex vivo system will require the use of large num

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaca08a61af0de12c64c3147d976fa64
https://doi.org/10.1007/s11626-997-0092-4

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Human Recombinant DNA–Derived Antihemophilic Factor (Factor VIII) in the Treatment of Hemophilia A

Publikováno v: New England Journal of Medicine. 323:1800-1805

Background. Current treatment of hemophilia A, a hereditary disorder affecting approximately 1 in 10,000 males, relies on plasma-derived factor VIII concentrates. We tested the safety and efficacy of a recombinant factor VIII preparation for the trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa65194039daa4fd1d452a6e100c5ae5
https://doi.org/10.1056/nejm199012273232604

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A 21-aminosteroid reduces hydrogen peroxide generation by and chemiluminescence of stimulated human leukocytes

Autor: Marc Fisher, Peter H. Levine, Ronald A. Cohen

Publikováno v: Stroke. 21:1435-1438

Leukocytes recruited to regions of focal cerebral ischemia may contribute to tissue injury by their ability to promote inflammation. A novel group of drugs, the 21-aminosteroids, have been observed to reduce neurologic damage and vasogenic cerebral e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e95c9429717b2efc56944476c274435b
https://doi.org/10.1161/01.str.21.10.1435

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A Proposed System of Classification of Hemophilia Centers for the World Federation of Hemophilia (W.F.H.)

Autor: H H Brackmann, U Seligsohn, Peter H. Levine

Publikováno v: Scandinavian Journal of Haematology. 33:459-460

At the request of the executive of the World Federation of Hemophilia, a uniform system for the classification of hemophilia centers has been devised. Three levels of centers are described: the hemophilia treatment unit, the comprehensive hemophilia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2bf208cccea2e83adb9b9335202ce09
https://doi.org/10.1111/j.1600-0609.1984.tb02601.x

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A 21‐aminosteroid inhibits stimulated monocyte hydrogen peroxide and chemiluminescence measurements from MS patients and controls

Autor: Marc Fisher, D. A. Bergeron, Ronald A. Cohen, Margaret M. Arpano, James J. Hoogasian, Elizabeth M. Doyle, Peter H. Levine

Publikováno v: Neurology. 41:297-297

Monocytes are recruited to active sites of multiple sclerosis (MS) demyelination and may promote local tissue injury by generating an inflammatory response, mediated in part by the production of toxic oxygen metabolites. Corticosteroids are frequentl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34242dee53ec8b255fee7a0f58df06f0
https://doi.org/10.1212/wnl.41.2_part_1.297

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