Zobrazeno 1 - 10
of 265
pro vyhledávání: '"Peter H Backx"'
Autor:
Jie Liu, Jason D Bayer, Roozbeh Aschar-Sobbi, Marianne Wauchop, Danna Spears, Michael Gollob, Edward J Vigmond, Robert Tsushima, Peter H Backx, Vijay S Chauhan
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197273 (2018)
BACKGROUND:The SCN5A mutation, P1332L, is linked to a malignant form of congenital long QT syndrome, type 3 (LQT3), and affected patients are highly responsive to the Na+ channel blocking drug, mexiletine. In contrast, A647D is an atypical SCN5A muta
Externí odkaz:
https://doaj.org/article/7a2d35b559e2465bbf94205a78d6d567
Autor:
Meghan C. Hughes, Sofhia V. Ramos, Aditya N. Brahmbhatt, Patrick C. Turnbull, Nazari N. Polidovitch, Madison C. Garibotti, Uwe Schlattner, Thomas J. Hawke, Jeremy A. Simpson, Peter H. Backx, Christopher GR. Perry
Publikováno v:
Redox Biology, Vol 76, Iss , Pp 103319- (2024)
Mitochondrial creatine kinase (mtCK) regulates the “fast” export of phosphocreatine to support cytoplasmic phosphorylation of ADP to ATP which is more rapid than direct ATP export. Such “creatine-dependent” phosphate shuttling is attenuated i
Externí odkaz:
https://doaj.org/article/a74cffb251704d729df4c25f1d7a8846
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133274 (2015)
Gradients of the fast transient outward K+ current (Ito,f) contribute to heterogeneity of ventricular repolarization in a number of species. Cardiac Ito,f levels and gradients change notably with heart disease. Human cardiac Ito,f appears to be encod
Externí odkaz:
https://doaj.org/article/19289de16fdb4740aff0c7bac1abffcc
Autor:
Linn S Strandberg, Xuezhi Cui, Arianna Rath, Jie Liu, Earl D Silverman, Xiaoru Liu, Vinayakumar Siragam, Cameron Ackerley, Brenda Bin Su, Jane Yuqing Yan, Marco Capecchi, Luca Biavati, Alice Accorroni, William Yuen, Filippo Quattrone, Kalvin Lung, Edgar T Jaeggi, Peter H Backx, Charles M Deber, Robert M Hamilton
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72668 (2013)
Congenital heart block (CHB) is a transplacentally acquired autoimmune disease associated with anti-Ro/SSA and anti-La/SSB maternal autoantibodies and is characterized primarily by atrioventricular (AV) block of the fetal heart. This study aims to in
Externí odkaz:
https://doaj.org/article/8c85fe89b54a42cf92297c7bd0c0fde3
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7712 (2009)
HCN channels are thought to be structurally similar to Kv channels, but show much lower selectivity for K+. The approximately 3.3 A selectivity filter of K+ channels is formed by the pore-lining sequence XT(V/I)GYG, with X usually T, and is held stab
Externí odkaz:
https://doaj.org/article/c63326a5628643cd9e7c694a5533a2bb
Autor:
Shuang Zheng, Weijiang Tan, Xiang Li, Lijing Wang, Caiyi Zhu, W. Glen Pyle, Jianxin Chen, Jian Wu, Xuecong Ren, Honghua Chen, Yunzeng Zou, Peter H. Backx, Feng Hua Yang
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: While the protective effects of n-3 polyunsaturated fatty acids (PUFAs) on cardiac ischemia-reperfusion (IR) injury have been previously reported, limited data are available regarding how these fatty acids affect membrane receptors and th
Externí odkaz:
https://doaj.org/article/2ee3dbf4f3ac48d49e42d5c5ad7ce9ee
Autor:
Cristine J. Reitz, Marjan Tavassoli, Da Hye Kim, Saumya Shah, Robert Lakin, Allen C. T. Teng, Yu-Qing Zhou, Wenping Li, Sina Hadipour-Lakmehsari, Peter H. Backx, Andrew Emili, Gavin Y. Oudit, Uros Kuzmanov, Anthony O. Gramolini
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The prognosis and treatment outcomes of heart failure (HF) patients rely heavily on disease etiology, yet the majority of underlying signaling mechanisms are complex and not fully elucidated. Phosphorylation is a major point of protein regulation wit
Autor:
Kyoung-Han Kim, Yena Oh, Jie Liu, Saif Dababneh, Ying Xia, Ri Youn Kim, Dae-Kyum Kim, Kiwon Ban, Mansoor Husain, Chi-Chung Hui, Peter H. Backx
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 322:H725-H741
Irx5 is a vital transcription factor that establishes the transmural heterogeneity of ventricular myocyte contractility, thereby ensuring proper contractile function in the healthy heart. Regional differences in excitation-contraction coupling in the
Autor:
Xuan Li, Jieyun You, Fangjie Dai, Shijun Wang, Fenghua Yang, Xingxu Wang, Zhiwen Ding, Jiayuan Huang, Liming Chen, Abudureyimu Miyesaier, Haiyang Tang, Xiangdong Yang, Yaozu Xiang, Peter H. Backx, Jun Ren, Junbo Ge, Yunzeng Zou, Jian Wu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5740f1720482060bd2df85f7c9a503c5
https://doi.org/10.2139/ssrn.4353527
https://doi.org/10.2139/ssrn.4353527
Autor:
Allen C. T. Teng, Liyang Gu, Michelle Di Paola, Robert Lakin, Zachary J. Williams, Aaron Au, Wenliang Chen, Neal I. Callaghan, Farigol Hakem Zadeh, Yu-Qing Zhou, Meena Fatah, Diptendu Chatterjee, L. Jane Jourdan, Jack Liu, Craig A. Simmons, Thomas Kislinger, Christopher M. Yip, Peter H. Backx, Robert G. Gourdie, Robert M. Hamilton, Anthony O. Gramolini
Publikováno v:
Nature Communications. 13
The intercalated disc (ICD) is a unique membrane structure that is indispensable to normal heart function, yet its structural organization is not completely understood. Previously, we showed that the ICD-bound transmembrane protein 65 (Tmem65) was re