Výsledky vyhledávání - "Peter Häusler"

Immunohistochemical Analysis of Thymidylate Synthase, Thymidine Phosphorylase, and Dihydropyrimidine Dehydrogenase in Rectal Cancer (cUICC II/III)

Autor: Christiane Jakob, Daniela E. Aust, Heinz Becker, W. Meyer, Gustavo Baretton, Peter Häusler, Torsten Liersch, Wolfgang Schwabe

Publikováno v: American Journal of Surgical Pathology. 29:1304-1309

In locally advanced rectal cancer, neoadjuvant 5-fluorouracil (5-FU)-based long-term chemoradiotherapy leads to marked tumor reduction and decrease of local recurrence rate. Thymidylate synthase (TS), thymidine phosphorylase (TP), and dihydropyrimidi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa33556f9f7af2dcbea19034563b5da
https://doi.org/10.1097/01.pas.0000170346.55304.88

Zobrazit plný text záznamu

High-level mRNA quantification of proliferation marker pKi-67 is correlated with favorable prognosis in colorectal carcinoma

Autor: Jian Liu, Rainer Broll, M. Duchrow, Peter Häusler, Hans-Peter Bruch, Wolfgang Schwabe, U. Windhövel, Thomas Ihmann, D. Behnke

Publikováno v: Journal of Cancer Research and Clinical Oncology. 130:749-756

The present study retrospectively examines the expression of pKi-67 mRNA and protein in colorectal carcinoma and their correlation to the outcome of patients.Immunohistochemistry and quantitative RT-PCR were used to analyze the expression of pKi-67 i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9502bacd67818b7d42663ebd542a93ca
https://doi.org/10.1007/s00432-004-0612-5

Zobrazit plný text záznamu

Thymidylate synthase, thymidine phosphorylase, dihydropyrimidine dehydrogenase expression, and histological tumour regression after 5-FU-based neo-adjuvant chemoradiotherapy in rectal cancer

Autor: W. Meyer, Daniela E. Aust, Peter Häusler, Wolfgang Schwabe, Heinz Becker, Christiane Jakob, Gustavo Baretton, Torsten Liersch

Publikováno v: The Journal of Pathology. 204:562-568

Pre-operative 5-fluorouracil (5-FU)-based chemoradiotherapy in locally advanced rectal cancer (UICC-II/III) may significantly reduce local tumour mass. Response to pre-operative treatment, however, varies significantly. Thymidylate synthase (TS), thy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f1828fb876fedfa82b9ad3b34f5b06
https://doi.org/10.1002/path.1663

Zobrazit plný text záznamu

Circadian variation of dihydropyrimidine dehydrogenase mRNA expression in leukocytes and serum cortisol levels in patients with advanced gastrointestinal carcinomas compared to healthy controls

Autor: Joachim H. Clement, M. Raida, Peter Häusler, Klaus Höffken, Wolfgang Schwabe, K. O. Kliche, D. Behnke

Publikováno v: Journal of Cancer Research and Clinical Oncology. 128:96-102

Purpose: The activity of dihydropyrimidine dehydrogenase (DPD) – the rate-limiting enzyme in fluorouracil (5-FU) catabolism – has been reported to vary according to the time of day. On the basis of this data, so-called chronomodulated chemotherap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da42fca20544a5501d725bc629265523
https://doi.org/10.1007/s00432-001-0309-y

Zobrazit plný text záznamu

Evaluation of 5-Fluorouracil Pharmacokinetics in Cancer Patients with a c.1905+1G > A Mutation in DPYD by Means of a Bayesian Limited Sampling Strategy

Autor: Kati Jabschinsky, Andreas Schalhorn, Peter Häusler, J. G. Maring, André B.P. van Kuilenburg, Johannes H. Proost, Michael W.T. Tanck, Wolfgang Schwabe, Christoph Terborg, D. Behnke

Publikováno v: Clinical Pharmacokinetics, 51(3), 163-174. Springer International Publishing AG
Clinical pharmacokinetics, 51(3), 163-174. Adis International Ltd

Background and Objective: Dihydropyrimidine dehydrogenase (DPD) is the initial enzyme in the catabolism of 5-fluorouracil (5FU) and DPD deficiency is an important pharmacogenetic syndrome. So far, only very limited information is available regarding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6edf7e5489cef7ab5dd6d16a2be996
https://research.rug.nl/en/publications/e4fa091b-9280-438e-bdfd-8b277d5c31c7

Zobrazit plný text záznamu

Pharmacokinetics of 5-fluorouracil in patients heterozygous for the IVS14+1GA mutation in the dihydropyrimidine dehydrogenase gene

Autor: Wolfgang Schwabe, K. Jabschinsky, D. Behnke, C. Terborg, Peter Häusler, J. G. Maring, A. B. P. Van Kuilenburg, H. Schmalenberg, A. Schalhorn

Publikováno v: Nucleosides, nucleotides & nucleic acids, 27(6), 692-698. Marcel Dekker Inc.

5-Fluorouracil (5FU) and capecitabine are two of the most frequently prescribed chemotherapeutic drugs for the treatment of patients with cancer. Administration of test doses of 5FU to eight patients heterozygous for the IVS14+1G > A mutation and fiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5348544dd49b5b62b2c6ce13e9c77049
https://pubmed.ncbi.nlm.nih.gov/18600527

Zobrazit plný text záznamu

Lymph node status and TS gene expression are prognostic markers in stage II/III rectal cancer after neoadjuvant fluorouracil-based chemoradiotherapy

Autor: Daniela E. Aust, Christiane Jakob, Bettina Kulle, Claus Langer, Gustavo Baretton, Torsten Liersch, B. Michael Ghadimi, Peter Häusler, Wolfgang Schwabe, Heinz Becker

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 24(25)

Purpose According to the CAO/ARO/AIO-94 trial of the German Rectal Cancer Study Group, preoperative combined fluorouracil (FU) -based long-term chemoradiotherapy (CT/RT) is recommended for patients with International Union Against Cancer (UICC) stage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a0fb3a9a349d9195f079f116bf0f68
https://pubmed.ncbi.nlm.nih.gov/16943520

Zobrazit plný text záznamu

Prognostic value of histologic tumor regression, thymidylate synthase, thymidine phosphorylase, and dihydropyrimidine dehydrogenase in rectal cancer UICC Stage II/III after neoadjuvant chemoradiotherapy

Autor: Gustavo Baretton, Christiane Jakob, Torsten Liersch, Peter Häusler, Heinz Becker, Daniela E. Aust, W. Meyer, Bettina Kulle, Wolfgang Schwabe

Publikováno v: The American journal of surgical pathology. 30(9)

Histologic tumor regression (TR) in rectal cancer after preoperative chemoradiotherapy (CT/RT) may be useful as a surrogate end point for early treatment efficacy, but little is known about its prognostic value. The aim of this follow-up study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e356bfcc4bb28e60e1c156437f006de0
https://pubmed.ncbi.nlm.nih.gov/16931962

Zobrazit plný text záznamu

Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil

Autor: Marko, Kornmann, Wolfgang, Schwabe, Silvia, Sander, Martina, Kron, Jörn, Sträter, Sucan, Polat, Erika, Kettner, Hans F, Weiser, Wolfram, Baumann, Harald, Schramm, Peter, Häusler, Kati, Ott, Detlev, Behnke, Ludger, Staib, Hans G, Beger, Karl H, Link

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 9(11)

Despite adjuvant 5-fluorouracil (5-FU) therapy, approximately 30% of patients with International Union against Cancer stage II and III colorectal cancer develop recurrence. In this study, we determined the prognostic value of thymidylate synthase (TS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e70c502a5ddb4434ba9f386f8194686e
https://pubmed.ncbi.nlm.nih.gov/14519634

Zobrazit plný text záznamu

Association of time to recurrence with thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression in stage II and III colorectal cancer

Publikováno v: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 6(3)

Patients with International Union Against Cancer (UICC) stage IIb and III colon cancer and stage II and III rectal cancer may receive adjuvant chemotherapy with 5-fluorouracil (5-FU). High levels of thymidylate synthase (TS) and dihydropyrimidine deh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73581cbf7f41303a99c258fa4e200c13
https://pubmed.ncbi.nlm.nih.gov/12022983

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání