Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Peter H, King"'
Autor:
Caesar M. Hernandez, Macy A. McCuiston, Kristian Davis, Yolanda Halls, Juan Pablo Carcamo Dal Zotto, Nateka L. Jackson, Lynn E. Dobrunz, Peter H. King, Lori L. McMahon
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 39, Iss , Pp 100798- (2024)
In addition to extracellular amyloid plaques, intracellular neurofibrillary tau tangles, and inflammation, cognitive and emotional affect perturbations are characteristic of Alzheimer's disease (AD). The cognitive and emotional domains impaired by AD
Externí odkaz:
https://doaj.org/article/504715aab0ea482fa47c628f92a6648d
Autor:
Mariángeles Kovacs, Catalina Alamón, Cecilia Maciel, Valentina Varela, Sofía Ibarburu, Lucas Tarragó, Peter H. King, Ying Si, Yuri Kwon, Olivier Hermine, Luis Barbeito, Emiliano Trias
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Abstract Degeneration of motor neurons, glial cell reactivity, and vascular alterations in the CNS are important neuropathological features of amyotrophic lateral sclerosis (ALS). Immune cells trafficking from the blood also infiltrate the affected C
Externí odkaz:
https://doaj.org/article/0bb5a531084d4897a403f95a98d581a9
Autor:
Ying Si, Mohamed Kazamel, Michael Benatar, Joanne Wuu, Yuri Kwon, Thaddaeus Kwan, Nan Jiang, Dominik Kentrup, Christian Faul, Lyndsy Alesce, Peter H. King
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive muscle weakness. Skeletal muscle is a prime source for biomarker discovery since it is one of the earliest sites to manifest disease pathol
Externí odkaz:
https://doaj.org/article/0f8008a5ad874d87a61a78f2f91ba8e9
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Skeletal muscle and the neuromuscular junction are the earliest sites to manifest pathological changes in amyotrophic lateral sclerosis (ALS). Based on prior studies, we have identified a molecular signature in muscle that develops early in
Externí odkaz:
https://doaj.org/article/5818ae8790184c18a4eb0a039ecf46e0
Autor:
Michael A. Lopez, Ying Si, Xianzhen Hu, Valentyna Williams, Fuad Qushair, Jackson Carlyle, Lyndsy Alesce, Michael Conklin, Shawn Gilbert, Marcas M. Bamman, Matthew S. Alexander, Peter H. King
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7515 (2022)
Duchenne muscular dystrophy (DMD) is an X-linked recessive disease characterized by skeletal muscle instability, progressive muscle wasting, and fibrosis. A major driver of DMD pathology stems from aberrant upregulation of transforming growth factor
Externí odkaz:
https://doaj.org/article/b5a1840f1eb54c35931546ac52798328
Autor:
Ikjae Lee, Mohamed Kazamel, Tarrant McPherson, Jeremy McAdam, Marcas Bamman, Amy Amara, Daniel L Smith, Peter H King
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251087 (2021)
Background/objectiveWeight loss is a predictor of shorter survival in amyotrophic lateral sclerosis (ALS). We performed serial measures of body composition using Dual-energy X-ray Absorptiometry (DEXA) in ALS patients to explore its utility as a biom
Externí odkaz:
https://doaj.org/article/cbf11b03b4c740548528a386c9a157d3
Publikováno v:
Journal of Neurochemistry. 164:643-657
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that selectively attacks motor neurons, and leads to progressive muscle weakness and death. A common pathological feature is the misfolding, aggregation, and cytoplasmic misloca
Publikováno v:
Journal of Clinical Neuromuscular Disease. 24:80-84
Docking protein 7 (DOK7) congenital myasthenic syndrome (CMS) is characterized by limb-girdle weakness and lack of fluctuating fatigability simulating many familial myopathies. Albuterol is the first line of therapy in view of consistent improvement.
Autor:
Abhishek Guha, Mohammed Amir Husain, Ying Si, L. Burt Nabors, Natalia Filippova, Grace Promer, Reed Smith, Peter H. King
Publikováno v:
Glia. 71:485-508
A major hallmark of neuroinflammation is the activation of microglia and astrocytes with the induction of inflammatory mediators such as IL-1β, TNF-α, iNOS, and IL-6. Neuroinflammation contributes to disease progression in a plethora of neurologica
Autor:
Ying Si, Xianqin Cui, David K. Crossman, Jiaying Hao, Mohamed Kazamel, Yuri Kwon, Peter H. King
Publikováno v:
Neurobiology of Disease, Vol 114, Iss , Pp 85-94 (2018)
ALS is a fatal neurodegenerative disorder of motor neurons leading to progressive atrophy and weakness of muscles. Some of the earliest pathophysiological changes occur at the level of skeletal muscle and the neuromuscular junction. We previously ide
Externí odkaz:
https://doaj.org/article/2d9018d9ab03460daa8f22edd630b1f4