Eosinophilic airway diseases: basic science, clinical manifestations and future challenges

Autor: Christer Janson, Leif Bjermer, Lauri Lehtimäki, Hannu Kankaanranta, Jussi Karjalainen, Alan Altraja, Valentyna Yasinska, Bernt Aarli, Madeleine Rådinger, Johan Hellgren, Magnus Lofdahl, Peter H Howarth, Celeste Porsbjerg

Publikováno v: European Clinical Respiratory Journal, Vol 9, Iss 1 (2022)

Eosinophils have a broad range of functions, both homeostatic and pathological, mediated through an array of cell surface receptors and specific secretory granules that promote interactions with their microenvironment. Eosinophil development, differe

Externí odkaz: https://doaj.org/article/cafaba4b62ec41c0be49070ccc7baacd

Clinical and transcriptomic features of persistent exacerbation‐prone severe asthma in U‐BIOPRED cohort

Autor: Uruj Hoda, Stelios Pavlidis, Aruna T. Bansal, Kentaro Takahashi, Sile Hu, Francois Ng Kee Kwong, Christos Rossios, Kai Sun, Pankaj Bhavsar, Matthew Loza, Frederic Baribaud, Pascal Chanez, Stephen J. Fowler, Ildiko Horvath, Paolo Montuschi, Florian Singer, Jacek Musial, Barbro Dahlen, Norbert Krug, Thomas Sandstrom, Dominic E. Shaw, Rene Lutter, Louise J. Fleming, Peter H. Howarth, Massimo Caruso, Ana R. Sousa, Julie Corfield, Charles Auffray, Bertrand De Meulder, Diane Lefaudeux, Sven‐Erik Dahlen, Ratko Djukanovic, Peter J. Sterk, Yike Guo, Ian M. Adcock, Kian Fan Chung, the U‐BIOPRED study group

Publikováno v: Clinical and Translational Medicine, Vol 12, Iss 4, Pp n/a-n/a (2022)

Abstract Background Exacerbation‐prone asthma is a feature of severe disease. However, the basis for its persistency remains unclear. Objectives To determine the clinical and transcriptomic features of frequent exacerbators (FEs) and persistent FEs

Externí odkaz: https://doaj.org/article/472cffbdc9ba4c16ac2d4d6cd89330da

The unified airway hypothesis: evidence from specific intervention with anti-interleukin-5 biologic therapy

Autor: Claus Bachert, Amber U. Luong, Philippe Gevaert, Joaquim Mullol, Steven G. Smith, Jared Silver, Ana R. Sousa, Peter H. Howarth, Victoria S. Benson, Bhabita Mayer, Robert H. Chan, William W. Busse

Publikováno v: The Journal of Allergy and Clinical Immunology: In Practice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1875b1cc95893e0b10eae11b5acfd94
https://doi.org/10.1016/j.jaip.2023.05.011

Airway remodelling rather than cellular infiltration characterizes both type2 cytokine biomarker‐high and ‐low severe asthma

Autor: Latifa Khalfaoui, Fiona A. Symon, Simon Couillard, Beverley Hargadon, Rekha Chaudhuri, Steve Bicknell, Adel H. Mansur, Rahul Shrimanker, Timothy S. C. Hinks, Ian D. Pavord, Stephen J. Fowler, Vanessa Brown, Lorcan P. McGarvey, Liam G. Heaney, Cary D. Austin, Peter H. Howarth, Joseph R. Arron, David F. Choy, Peter Bradding

Publikováno v: Khalfaoui, L, Symon, F A, Couillard, S, Hargadon, B, Chaudhuri, R, Bicknell, S, Mansur, A H, Shrimanker, R, Hinks, TS C, Pavord, I D, Fowler, S J, Brown, V, McGarvey, L P, Heaney, L G, Austin, C D, Howarth, P H, Arron, J R, Choy, D F & Bradding, P 2022, ' Airway remodelling rather than cellular infiltration characterizes both type2 cytokine biomarker-high and -low severe asthma ', Allergy . https://doi.org/10.1111/all.15376
UK Medical Research Council Refractory Asthma Stratification programme (RASP-UK) 2022, ' Airway remodelling rather than cellular infiltration characterises both type2 cytokine biomarker-high and-low severe asthma ', Allergy . https://doi.org/10.1111/all.15376

Background: The most recognizable phenotype of severe asthma comprises people who are blood eosinophil and FeNO-high, driven by type-2 (T2) cytokine biology which responds to targeted biological therapies. However, in many people with severe asthma,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d335eaa0fe9178f81b6b89fe40cd151
https://doi.org/10.1111/all.15376

Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort.

Autor: Rosalia Emma, Aruna T Bansal, Johan Kolmert, Craig E Wheelock, Swen-Erik Dahlen, Matthew J Loza, Bertrand De Meulder, Diane Lefaudeux, Charles Auffray, Barbro Dahlen, Per S Bakke, Pascal Chanez, Stephen J Fowler, Ildiko Horvath, Paolo Montuschi, Norbert Krug, Marek Sanak, Thomas Sandstrom, Dominick E Shaw, Louise J Fleming, Ratko Djukanovic, Peter H Howarth, Florian Singer, Ana R Sousa, Peter J Sterk, Julie Corfield, Ioannis Pandis, Kian F Chung, Ian M Adcock, René Lutter, Lorena Fabbella, Massimo Caruso, U-BIOPRED Study Group

Publikováno v: PLoS ONE, Vol 13, Iss 9, p e0203874 (2018)

Oxidative stress is believed to be a major driver of inflammation in smoking asthmatics. The U-BIOPRED project recruited a cohort of Severe Asthma smokers/ex-smokers (SAs/ex) and non-smokers (SAn) with extensive clinical and biomarker information ena

Externí odkaz: https://doaj.org/article/a176a9f785e1455ab33c06826982b773