Pharmacokinetic Effects and Safety of Olaparib Administered with Endocrine Therapy: A Phase I Study in Patients with Advanced Solid Tumours

Autor: C. Goessl, Stuart Spencer, Jacques De Greve, Luc Dirix, Antoine Italiano, Christian Rolfo, Filip de Vos, Karin Leunen, Henk M.W. Verheul, Joseph Birkett, Emma Dean, L Rhoda Molife, Sylvie Rottey, Maria Learoyd, Guy Jerusalem, Ruth Plummer, James Spicer, Peter Grundtvig-Sørensen, Christopher Bailey

Publikováno v: Advances in therapy
Advances in therapy, 35(11), 1945-1964. Health Communications Inc.
Plummer, R, Verheul, H M, de Vos, F Y F L, Leunen, K, Molife, L R, Rolfo, C, Grundtvig-Sørensen, P, de Grève, J, Rottey, S, Jerusalem, G, Italiano, A, Spicer, J, Dirix, L, Goessl, C, Birkett, J, Spencer, S, Learoyd, M, Bailey, C & Dean, E 2018, ' Pharmacokinetic Effects and Safety of Olaparib Administered with Endocrine Therapy: A Phase I Study in Patients with Advanced Solid Tumours ', Advances in therapy, vol. 35, no. 11, pp. 1945-1964 . https://doi.org/10.1007/s12325-018-0804-z

Introduction: The PARP inhibitor olaparib is efficacious as monotherapy and has potential application in combination with endocrine therapy for the treatment of breast cancer. This phase I study assessed the safety and pharmacokinetic (PK) profiles o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373a97883893d974129df40544667f03
https://pubmed.ncbi.nlm.nih.gov/30324586

Mediators of inflammation correlate with microalbuminuria in patients with non-Hodgkin's lymphoma

Autor: Peter Grundtvig Sørensen, Lars Møller Pedersen

Publikováno v: British Journal of Haematology. 121:275-279

Recent studies have demonstrated a high frequency of minor glomerular leakage of albumin in cancer patients. Pathogenic mechanisms of increased urinary albumin excretion (UAE) in malignancies remain to be clarified. We have attempted to identify whet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c12bb898073c6ad1613ee7c14cf0de37
https://doi.org/10.1046/j.1365-2141.2003.04285.x

Clinical significance of urinary albumin excretion in patients with non-Hodgkin's lymphoma

Autor: Lars Møller Pedersen, Peter Grundtvig Sørensen

Publikováno v: British Journal of Haematology. 107:889-891

Slightly increased urinary albumin excretion rates (UAE) have been reported in patients with various types of human cancer. We measured UAE in 24 h urine samples from 48 untreated patients with non-Hodgkin's lymphoma at diagnosis. In patients with a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7dd04e19b18c0c5719b214ae09c9104
https://doi.org/10.1046/j.1365-2141.1999.01772.x

Magnetic Resonance Imaging of the Bone Marrow following Treatment with Recombinant Human Erythropoietin in Patients with End-Stage Renal Disease

Autor: Birgitte Nielsen, Hans Karle, Karl Erik Jensen, Ole Henriksen, Peter Grundtvig Sørensen, Carsten Thomsen, Mikael Jensen, D Stenver

Publikováno v: The International Journal of Artificial Organs. 13:477-481

We used magnetic resonance imaging (MRI) to study vertebral bone marrow in hemodialysis patients during treatment with recombinant human erythropoietin (rHuEPO). We found changes in T1 relaxation times and image contrast within 14 days after starting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::154a94db6e0bfad0f0ae376f3219b881
https://doi.org/10.1177/039139889001300806

Prolonged bone marrow T1-relaxation in acute leukaemia. In vivo tissue characterization by magnetic resonance imaging

Autor: Peter Grundtvig Sørensen, Per Christoffersen, Hans Karle, Ole Henriksen, Carsten Thomsen

Publikováno v: Magnetic Resonance Imaging. 5:251-257

In vivo tissue characterization by measurement of T1- and T2-relaxation processes is one of the greatest potentials of magnetic resonance imaging (MRI). This may be especially useful in the evaluation of bone marrow disorders as the MRI-signal from b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99565b5c1e0563192d431d72d609413f
https://doi.org/10.1016/0730-725x(87)90001-4