Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Peter Grimm"'
Autor:
Peter Obel Otto, Martina K. Loft, Peter Grimm, Søren Rafael Rafaelsen, Malene Roland V. Pedersen
Publikováno v:
European Journal of Radiology Open, Vol 8, Iss , Pp 100376- (2021)
Primary leiomyosarcoma of the colon mesentery is an extremely rare neoplasm, and only a small number of cases have been reported. We describe a case of leiomyosarcoma originating in the colonic mesentery, in a 68-year-old woman. Ultrasound showed a h
Externí odkaz:
https://doaj.org/article/7c90bbaa563b432dbe39c8c1869aa3a9
Autor:
Volker Teichgräber, Pavel Pisa, Alex Phipps, Jean Eric Charoin, Jean Tessier, Christian Klein, Stefan Evers, Jehad Charo, Hans Peter Grimm, Tapan Nayak, Christophe Boetsch, Benjamin Ribba
Supplemental legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a35ccf90ebb95538b3b96ffdcec280c
https://doi.org/10.1158/1078-0432.22465131.v1
https://doi.org/10.1158/1078-0432.22465131.v1
Autor:
Marina Bacac, Christian Gerdes, Pablo Umana, Christian Klein, Markus Rudin, Szymon Stoma, Jörg Zielonka, Anne Freimoser-Grundschober, Teilo Schaller, Linda Fahrni, Tanja Fauti, Sara Colombetti, Johannes Sam, Hans-Peter Grimm, Ramanil Perera, Steffi Lehmann
Supplementary Methods and Figure Legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::575b652a7c3a4cc1f4a4120f33b42e6b
https://doi.org/10.1158/1078-0432.22458585.v1
https://doi.org/10.1158/1078-0432.22458585.v1
Autor:
Marina Bacac, Christian Gerdes, Pablo Umana, Christian Klein, Markus Rudin, Szymon Stoma, Jörg Zielonka, Anne Freimoser-Grundschober, Teilo Schaller, Linda Fahrni, Tanja Fauti, Sara Colombetti, Johannes Sam, Hans-Peter Grimm, Ramanil Perera, Steffi Lehmann
Purpose: CEA TCB (RG7802, RO6958688) is a novel T-cell bispecific antibody, engaging CD3ϵ upon binding to carcinoembryonic antigen (CEA) on tumor cells. Containing an engineered Fc region, conferring an extended blood half-life while preventing side
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282e31f78b9c3a54cc232548148aa81d
https://doi.org/10.1158/1078-0432.c.6523992
https://doi.org/10.1158/1078-0432.c.6523992
Autor:
Marina Bacac, Christian Gerdes, Pablo Umana, Christian Klein, Markus Rudin, Szymon Stoma, Jörg Zielonka, Anne Freimoser-Grundschober, Teilo Schaller, Linda Fahrni, Tanja Fauti, Sara Colombetti, Johannes Sam, Hans-Peter Grimm, Ramanil Perera, Steffi Lehmann
In vitro live cell confocal imaging of LS174T RFP cells co-cultured with CFSE-labeled T-cells (E:T = 3:1) in the presence of CEA or a control TCB, respectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ebe1331a20f2b3c35ab98751963a63
https://doi.org/10.1158/1078-0432.22458582.v1
https://doi.org/10.1158/1078-0432.22458582.v1
Autor:
Volker Teichgräber, Pavel Pisa, Alex Phipps, Jean Eric Charoin, Jean Tessier, Christian Klein, Stefan Evers, Jehad Charo, Hans Peter Grimm, Tapan Nayak, Christophe Boetsch, Benjamin Ribba
Supplementary Figure S1: Left: CEA expression by immuno-histochemistry in the LS174T tumor mouse model: homogeneous cytoplasmic antigen distribution. Right: CEA expression in one of the treated patients (colorectal cancer): heterogeneous cytoplasmic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b987aad8cb87c9dc01c6d5be388abbc
https://doi.org/10.1158/1078-0432.22465140
https://doi.org/10.1158/1078-0432.22465140
Autor:
Marina Bacac, Christian Gerdes, Pablo Umana, Christian Klein, Markus Rudin, Szymon Stoma, Jörg Zielonka, Anne Freimoser-Grundschober, Teilo Schaller, Linda Fahrni, Tanja Fauti, Sara Colombetti, Johannes Sam, Hans-Peter Grimm, Ramanil Perera, Steffi Lehmann
Supplementary Figure S1. CEA TCB leads stimulates the expression of CD25, a T-cell activation marker, on both T-helper (CD4+) and cytotoxic T-cells (CD8+) after incubation with LS174T tumor cells. Supplementary Figure S2. CEA TCB induces efficient MK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18733e4175bd0a2bf64931d79e4cff70
https://doi.org/10.1158/1078-0432.22458588.v1
https://doi.org/10.1158/1078-0432.22458588.v1
Autor:
Marina Bacac, Christian Gerdes, Pablo Umana, Christian Klein, Markus Rudin, Szymon Stoma, Jörg Zielonka, Anne Freimoser-Grundschober, Teilo Schaller, Linda Fahrni, Tanja Fauti, Sara Colombetti, Johannes Sam, Hans-Peter Grimm, Ramanil Perera, Steffi Lehmann
2P time-lapse acquisition of LS174T / human PBMC cografts on day 4 after implantation (baseline), 24 h after control and 24 h after CEA TCB treatment. LS174T RFP tumor cells (red), CFSE labeled T-cells (green). Scale bar indicates 50 μm.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b5873f3a8b5eb1ba7e0244642de216
https://doi.org/10.1158/1078-0432.22458567.v1
https://doi.org/10.1158/1078-0432.22458567.v1
Autor:
Volker Teichgräber, Pavel Pisa, Alex Phipps, Jean Eric Charoin, Jean Tessier, Christian Klein, Stefan Evers, Jehad Charo, Hans Peter Grimm, Tapan Nayak, Christophe Boetsch, Benjamin Ribba
Purpose: Optimal dosing is critical for immunocytokine-based cancer immunotherapy to maximize efficacy and minimize toxicity. Cergutuzumab amunaleukin (CEA-IL2v) is a novel CEA-targeted immunocytokine. We set out to develop a mathematical model to pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2556a1ba8acaa2fde530ba00d2a6d156
https://doi.org/10.1158/1078-0432.c.6525936
https://doi.org/10.1158/1078-0432.c.6525936
Autor:
Marina Bacac, Christian Gerdes, Pablo Umana, Christian Klein, Markus Rudin, Szymon Stoma, Jörg Zielonka, Anne Freimoser-Grundschober, Teilo Schaller, Linda Fahrni, Tanja Fauti, Sara Colombetti, Johannes Sam, Hans-Peter Grimm, Ramanil Perera, Steffi Lehmann
Ex vivo analysis of the CEA TCB (magenta) mediated cross-linking of CFSE labeled T-cells (green) to tumor cells. 3D reconstructions of confocal z-stacks acquired on tumor sections obtained from huPBMC (CFSE labeled T-cells)/LS174T RFP co-grafts, 24 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6c5c94a228a9aab286e3846136201f
https://doi.org/10.1158/1078-0432.22458570
https://doi.org/10.1158/1078-0432.22458570