Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Peter Gohlke"'
Publikováno v:
Journal of Molecular Medicine (Berlin, Germany)
Abstract The present study elucidates the neuroprotective mechanisms of the PPARγ (peroxisome proliferator-activated receptor γ) agonist pioglitazone in survival of ischemic neurons following middle cerebral artery occlusion with reperfusion (MCAO)
Autor:
Sukhbir S. Dhamrait, Cecilia Maubaret, Ulrik Pedersen-Bjergaard, David J. Brull, Peter Gohlke, John R. Payne, Michael World, Birger Thorsteinsson, Steve E. Humphries, Hugh E. Montgomery
Publikováno v:
Inside the Cell
Uncoupling proteins (UCPs) regulate mitochondrial function, and thus cellular metabolism. Angiotensin‐converting enzyme (ACE) is the central component of endocrine and local tissue renin–angiotensin systems (RAS), which also regulate diverse aspe
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 388:939-951
Omapatrilat (OMA), which simultaneously inhibits the angiotensin-converting enzyme (ACE) and the neutral endopeptidase (neprilysin (NEP)), is widely used in experimental protocols related to hypertension and heart failure. The penetration of OMA acro
Autor:
Toni Jacob, Leonie Brolund, Juraj Culman, Yi Zhao, Peter Gohlke, Ingolf Cascorbi, Sven O. Schuster, Kjell Brolund-Spaether
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 390(9)
The present study conducted in rats defines the requirements for neuroprotective effects of systemically administered AT1 receptor blockers (ARBs) in acute ischaemic stroke. The inhibition of central effects to angiotensin II (ANG II) after intraveno
Autor:
Peter Gohlke, Thomas Herdegen, Miriam Nguyen-Ngoc, Yi Zhao, Ivonne Stöck, Torben Glatz, Juraj Culman
Publikováno v:
Journal of Hypertension. 28:1488-1497
The imbalance between the production and release of interleukin-1 (IL-1) ligands, IL-1alpha, IL-1beta and IL-1 receptor antagonist (IL-1ra) in ischaemic brain exaggerates inflammatory responses and contributes to neuronal death. Cerebral ischaemia al
Publikováno v:
European Journal of Neuroscience. 28:1786-1794
Interleukin-6 (IL-6) exerts neuroprotective effects after cerebral ischaemia but can also exacerbate inflammation and induce neuronal death. The current study investigates the role of cerebral peroxisome proliferator-activated receptor(s) gamma (PPAR
Autor:
John R. Payne, Brian Rayner, Sukhbir S. Dhamrait, Yannis P. Pitsiladis, Peter Gohlke, J.A. Cooper, Robert A. Scott, Hugh Montgomery, S.E. Humphries
Publikováno v:
Annals of Human Genetics. 71:1-7
The strong association between the angiotensin I-converting enzyme (ACE) gene I/D polymorphism with serum ACE activity appears lacking in Nigerians and Kenyans, but has not previously been well assessed in others of African origin. This study address
Publikováno v:
Journal of Hypertension. 25:187-196
The effects of candesartan treatment starting early (3 h) and delayed (24 h) after middle cerebral artery occlusion (MCAO) with reperfusion was investigated in normotensive rats.Subcutaneous treatment with candesartan (0.3 and 3 mg/kg) or vehicle was
Autor:
Joanna Harris, Peter Gohlke, Julie Sanders, Hugh Montgomery, Steve E. Humphries, Jackie A. Cooper, David R. Woods
Publikováno v:
Journal of the Renin-Angiotensin-Aldosterone System, Vol 7 (2006)
myocardial ischaemia, angiotensin- converting enzyme, oestrogen, renin-angiotensin system, genotype Abstract Introduction. The Deletion (D) rather than Insertion (I) variant of the angiotensin-converting enzyme (ACE) gene is associated with higher ci
Publikováno v:
European Journal of Applied Physiology. 99:11-18
The insertion (I) variant of the angiotensin-1 converting enzyme (ACE) I/D genetic polymorphism is associated with lower circulating and tissue ACE activity. Some studies have also suggested associations of ACE I/D genotype with endurance phenotypes.