Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Peter Gochman"'
Autor:
Gabriel E. Hoffman, Brigham J. Hartley, Erin Flaherty, Ian Ladran, Peter Gochman, Douglas M. Ruderfer, Eli A. Stahl, Judith Rapoport, Pamela Sklar, Kristen J. Brennand
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Induced pluripotent stem cell (hiPSC)-based models have inherent variations in their cellular and molecular output and readouts. Here, Hoffman and colleagues devise a method to account for gene expression variations in hiPSC-derived neurons from pati
Externí odkaz:
https://doaj.org/article/99c9b01d94b044f2bf2ad26960baaf9f
Autor:
Andjela Markovic, Diane Dillard-Broadnax, David I. Driver, Ashura W. Buckley, Kerstin Hoedlmoser, Leila Tarokh, Judith L. Rapoport, Peter Gochman
Publikováno v:
Journal of Sleep Research. 30
Altered sleep neurophysiology has consistently been reported in adult patients with schizophrenia. Converging evidence suggests that childhood onset schizophrenia (COS), a rare but severe form of schizophrenia, is continuous with adult onset schizoph
Autor:
Peter Gochman, Diane Dillard-Broadnax, Andjela Markovic, Kerstin Hoedlmoser, Judith L. Rapoport, Leila Tarokh, Ashura W. Buckley, David I. Driver
Publikováno v:
Schizophr Res
Neuroimaging studies of childhood onset schizophrenia (COS), a rare yet severe form of schizophrenia with an onset before the age of 13 years, have shown continuity with adult onset schizophrenia. Previous research in adult patients has shown reduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f22e5fbb58f7c2775ba10ef55931468
Autor:
Liv S. Clasen, Stephen J. Gotts, Rebecca E. Watsky, Xueping Zhou, Anna E. Ordóñez, M Deanna, Peter Gochman, Siyuan Liu, Dede Greenstein, Rebecca A. Berman, Francois Lalonde, Lorie Shora, Alex Martin, Harrison McAdams, Judith L. Rapoport, Nitin Gogtay
Publikováno v:
Schizophrenia Research. 197:219-225
Childhood-onset schizophrenia (COS) is a rare, severe form of the adult-onset disorder (AOS). Our previous resting-state fMRI study identified attenuated functional connectivity in COS compared with controls. Here, we ask whether COS and AOS patients
Autor:
Michael B. Fernando, Natalie Barretto, Kristen J. Brennand, Nadine Schrode, Esther Cheng, Robert Sebra, Gintaras Deikus, Megan L. Fitzgerald, Robert E. McCullumsmith, Erin Flaherty, P J Michael Deans, Peter Gochman, Nancy Francoeur, Judith L. Rapoport, Hardik Shah, Ian Ladran, Alesia Antoine, Nadejda M. Tsankova, Shijia Zhu, Gabriel E. Hoffman, Madeline Halpern, Khaled Alganem, Gang Fang
Publikováno v:
Nature genetics
NRXN1 undergoes extensive alternative splicing, and non-recurrent heterozygous deletions in NRXN1 are strongly associated with neuropsychiatric disorders. We establish that human induced pluripotent stem cell (hiPSC)-derived neurons represent well th
Autor:
Bruce J. Aronow, Aaron Topol, Jonathan A. Ellman, Chimezie Ononenyi, Carty Nc, Angus C. Nairn, Ulrich Müller, A. Phillips, Jian Xu, Seok-Man Ho, Christopher Pittenger, Michael W. Nestor, Paul J. Lombroso, Sounak Gupta, Ethan Foscue, Kristen J. Brennand, Tyler D. Baguley, Judith L. Rapoport, Claudia S. Barros, Brigham J. Hartley, Peter Gochman, M. Xu, Pradeep Kurup
Publikováno v:
Molecular Psychiatry. 23:271-281
The brain-specific tyrosine phosphatase, STEP (STriatal-Enriched protein tyrosine Phosphatase) is an important regulator of synaptic function. STEP normally opposes synaptic strengthening by increasing N-methyl D-aspartate glutamate receptor (NMDAR)
Publikováno v:
American Journal of Medical Genetics
We report two cases of paternally inherited 15q13.3 duplications in carriers diagnosed with childhood-onset schizophrenia (COS), a rare neurodevelopmental disorder of proposed polygenic origin with onset in children before age 13. This study document
Autor:
Anna E. Ordóñez, Lorie Shora, Diane Dillard-Broadnax, Deanna Greenstein, Katharine Ludovici Pollard, Rebecca A. Berman, Liv S. Clasen, Rebecca E. Watsky, Nitin Gogtay, Judith L. Rapoport, Peter Gochman
Publikováno v:
Journal of the American Academy of Child & Adolescent Psychiatry. 55:130-136
Objective This study investigated the relationship between regional cortical gray matter thinning and symptoms of schizophrenia spectrum personality disorders (PDs) in siblings of patients with childhood-onset schizophrenia (COS). Method A total of 6
Autor:
John F. Crary, Gang Fang, Kristen J. Brennand, Esther Cheng, Gintaras Deikus, Judith L. Rapoport, Erin Absherty, Nadejda M. Tsankova, Madeline Halpern, Alesia Antoine, Peter Gochman, Robert Sebra, Shijia Zhu, Gabriel E. Hoffman
Publikováno v:
European Neuropsychopharmacology. 29:S1077-S1078