Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Peter Gierschik"'
Autor:
Jialei Qi, Martin Wist, Eugen Tausch, Deyan Yordanov Yosifov, Anja Schade, Xiang Gao, Rashmi Priyadharshini Dheenadayalan, Christof Schneider, Sascha Endres, Daniel Mertens, Peter Gierschik, Stephan Stilgenbauer, Billy Michael Chelliah Jebaraj
Publikováno v:
HemaSphere, Vol 7, p e6991152 (2023)
Externí odkaz:
https://doaj.org/article/0cb9fab158e243ee84050d99fbc1c541
Autor:
Julia Zinngrebe, Barbara Moepps, Thomas Monecke, Peter Gierschik, Ferdinand Schlichtig, Thomas F E Barth, Gudrun Strauß, Elena Boldrin, Carsten Posovszky, Ansgar Schulz, Ortraud Beringer, Eva Rieser, Eva‐Maria Jacobsen, Myriam Ricarda Lorenz, Klaus Schwarz, Ulrich Pannicke, Henning Walczak, Dierk Niessing, Catharina Schuetz, Pamela Fischer‐Posovszky, Klaus‐Michael Debatin
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 3, Pp 1-16 (2022)
Abstract Autoinflammatory diseases are a heterogenous group of disorders defined by fever and systemic inflammation suggesting involvement of genes regulating innate immune responses. Patients with homozygous loss‐of‐function variants in the OTU
Externí odkaz:
https://doaj.org/article/83cf35280c7b412da8856b8b0ae57fcf
Autor:
Stefan Taudien, Ludwig Lausser, Evangelos J. Giamarellos-Bourboulis, Christoph Sponholz, Franziska Schöneweck, Marius Felder, Lyn-Rouven Schirra, Florian Schmid, Charalambos Gogos, Susann Groth, Britt-Sabina Petersen, Andre Franke, Wolfgang Lieb, Klaus Huse, Peter F. Zipfel, Oliver Kurzai, Barbara Moepps, Peter Gierschik, Michael Bauer, André Scherag, Hans A. Kestler, Matthias Platzer
Publikováno v:
EBioMedicine, Vol 12, Iss C, Pp 227-238 (2016)
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection. For its clinical course, host genetic factors are important and rare genomic variants are suspected to contribute. We sequenced the exomes of 59 Greek a
Externí odkaz:
https://doaj.org/article/b21551ea7a7846d5bfa0e376e79a0c70
Autor:
Onofrio Zirafi, Kyeong-Ae Kim, Ludger Ständker, Katharina B. Mohr, Daniel Sauter, Anke Heigele, Silvia F. Kluge, Eliza Wiercinska, Doreen Chudziak, Rudolf Richter, Barbara Moepps, Peter Gierschik, Virag Vas, Hartmut Geiger, Markus Lamla, Tanja Weil, Timo Burster, Andreas Zgraja, Francois Daubeuf, Nelly Frossard, Muriel Hachet-Haas, Fabian Heunisch, Christoph Reichetzeder, Jean-Luc Galzi, Javier Pérez-Castells, Angeles Canales-Mayordomo, Jesus Jiménez-Barbero, Guillermo Giménez-Gallego, Marion Schneider, James Shorter, Amalio Telenti, Berthold Hocher, Wolf-Georg Forssmann, Halvard Bonig, Frank Kirchhoff, Jan Münch
Publikováno v:
Cell Reports, Vol 11, Iss 5, Pp 737-747 (2015)
CXCL12-CXCR4 signaling controls multiple physiological processes and its dysregulation is associated with cancers and inflammatory diseases. To discover as-yet-unknown endogenous ligands of CXCR4, we screened a blood-derived peptide library for inhib
Externí odkaz:
https://doaj.org/article/6f4fd359e6c246c58166a8fdf0934801
Autor:
Jialei Qi, Sascha Endres, Deyan Yordanov Yosifov, Eugen Tausch, Rashmi Priyadharshini Dheenadayalan, Xiang Gao, Annika Scheffold, Felix Seyfried, Lüder Meyer, Christof Schneider, Daniel Mertens, Peter Gierschik, Martin Wist, Stephan Stilgenbauer, Billy Michael Chelliah Jebaraj
Publikováno v:
Blood. 140:3139-3141
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f65ad8374a68ff86305086ebe4f73727
https://doi.org/10.1182/blood-2022-159427
https://doi.org/10.1182/blood-2022-159427
Autor:
Jialei Qi, Sascha Endres, Deyan Yordanov Yosifov, Eugen Tausch, Rashmi Priyadharshini Dheenadayalan, Xiang Gao, Annika Müller, Christof Schneider, Daniel Mertens, Peter Gierschik, Martin Wist, Billy Michael Chelliah Jebaraj, Stephan Stilgenbauer
Publikováno v:
Blood Advances.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c2f8386c58ccbb2539327b5009659e8
https://doi.org/10.1182/bloodadvances.2022008955
https://doi.org/10.1182/bloodadvances.2022008955
Autor:
Reinhild Rösler, Claudia Walliser, Jennifer Haas, Sascha Endres, Peter Gierschik, Yuan Zhou, Martin Wist, Orit Gutman, Laura Meier, Elias Hobeika, Stephan Stilgenbauer, Yoav I. Henis, Sebastian Wiese
Publikováno v:
J Biol Chem
Treatment of patients with chronic lymphocytic leukemia (CLL) with inhibitors of Bruton's tyrosine kinase (BTK), such as ibrutinib, is limited by primary or secondary resistance to this drug. Examinations of CLL patients with late relapses while on i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f656de821a428bb5dfc3f0b3ef2993e2
https://doi.org/10.1074/jbc.ra119.011946
https://doi.org/10.1074/jbc.ra119.011946
Autor:
Guenter Schultz, Peter Gierschik, Dagmar Meyer zu Heringdorf, Klaus Aktories, Thomas Wieland, Martina Schmidt
Publikováno v:
Naunyn-Schmiedebergs Archives of Pharmacology. 392(8):887-911
Karl H. Jakobs, former editor-in-chief of Naunyn-Schmiedeberg's Archives of Pharmacology and renowned molecular pharmacologist, passed away in April 2018. In this article, his scientific achievements regarding G protein-mediated signal transduction a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee0168eaad3ca10efa35ed328b817a7
https://hdl.handle.net/11370/0e90105a-8fa8-4446-b59c-7e63d0ed34d5
https://hdl.handle.net/11370/0e90105a-8fa8-4446-b59c-7e63d0ed34d5
Autor:
Eugen Tausch, Stephan Stilgenbauer, Annika Müller, Felix Seyfried, Sascha Endres, Martina Seiffert, Rashmi Priyadharshini Dheenadayalan, Martin Wist, Klaus-Michael Debatin, Daniel Mertens, Billy Michael Chelliah Jebaraj, Judith A. Fox, Lueder H. Meyer, Philipp M. Roessner, Claudia Walliser, Peter Gierschik, Jialei Qi, Pietro Taverna
Publikováno v:
Blood. 139(6)
Covalent Bruton tyrosine kinase (BTK) inhibitors, such as ibrutinib, have proven to be highly beneficial in the treatment of chronic lymphocytic leukemia (CLL). Interestingly, the off-target inhibition of IL-2-inducible T-cell kinase (ITK) by ibrutin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1f082dc6ecb91748c1f7e55d47cc597
https://pubmed.ncbi.nlm.nih.gov/35142854
https://pubmed.ncbi.nlm.nih.gov/35142854
Autor:
Jan-Bernd Funcke, Barbara Moepps, Julia von Schnurbein, Stephanie Brandt, Belinda Lennerz, Peter Gierschik, Pamela Fischer-Posovszky, Guntram Borck, Adriana Nunziata, Martin Wabitsch
Publikováno v:
Journal of the Endocrine Society
Several case series of extreme early-onset obesity due to mutations in the human leptin receptor (LEPR) gene have been reported. In this review we summarize published functional and phenotypic data on mutations in the human LEPR gene causing severe e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d6d66904e720be8c378d9e453b6ea6
https://doi.org/10.1210/js.2018-00123
https://doi.org/10.1210/js.2018-00123