Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Peter G. Nell"'
Autor:
Katja Zimmermann, Nicole Diedrichs, Walter Hübsch, Alexandros Vakalopoulos, Hans-Georg Lerchen, Thomas Kramer, Frank Süssmeier, Barbara Albrecht-Küpper, Raimund Kast, Ursula Krenz, Daniel Meibom, Peter G. Nell, Joachim Mittendorf
Publikováno v:
ChemMedChem. 12:728-737
Adenosine is known to be released under a variety of physiological and pathophysiological conditions to facilitate the protection and regeneration of injured ischemic tissues. The activation of myocardial adenosine A1 receptors (A1Rs) has been shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::980d62cd9e6ae9380c0011ac41a9a756
https://doi.org/10.1002/cmdc.201700151
https://doi.org/10.1002/cmdc.201700151
Autor:
Daniel, Meibom, Barbara, Albrecht-Küpper, Nicole, Diedrichs, Walter, Hübsch, Raimund, Kast, Thomas, Krämer, Ursula, Krenz, Hans-Georg, Lerchen, Joachim, Mittendorf, Peter G, Nell, Frank, Süssmeier, Alexandros, Vakalopoulos, Katja, Zimmermann
Publikováno v:
ChemMedChem. 12(10)
Adenosine is known to be released under a variety of physiological and pathophysiological conditions to facilitate the protection and regeneration of injured ischemic tissues. The activation of myocardial adenosine A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f63ae1aaa2ba4a447ae5d3791b0a6ba2
https://pubmed.ncbi.nlm.nih.gov/28488817
https://pubmed.ncbi.nlm.nih.gov/28488817
Publikováno v:
Purinergic Signalling. 8:91-99
Adenosine, a purine nucleoside, is present in all cells in tightly regulated concentrations. It has many different physiological effects in the whole body and in the heart. Adenosine activates four G protein-coupled receptors A1, A2a, A2b, and A3. Ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf17bbbff6cb15edf21abaee0a30e8f6
https://doi.org/10.1007/s11302-011-9274-3
https://doi.org/10.1007/s11302-011-9274-3
Publikováno v:
Chemistry - A European Journal. 6:3359-3365
alpha-Chloro- and alpha-bromoalkyl Grignard reagents 11 and 30 with > 97% ee (enantiomeric excess) were generated by a sulfoxide/magnesium exchange reaction from the enantiomerically and diastereomerically pure sulfoxides 25 and 27. The resulting alp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd168c771d92d809532871f267184e92
https://doi.org/10.1002/1521-3765(20000915)6:18<3359::aid-chem3359>3.0.co
https://doi.org/10.1002/1521-3765(20000915)6:18<3359::aid-chem3359>3.0.co
Publikováno v:
Progress in medicinal chemistry. 47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ec2f7705521e90999d07b83f1bedd764
https://pubmed.ncbi.nlm.nih.gov/19328291
https://pubmed.ncbi.nlm.nih.gov/19328291
Autor:
Peter G. Nell, Reinhard W. Hoffmann
Publikováno v:
Angewandte Chemie International Edition. 38:338-340
Not only for ligand exchange at sulfoxides can the sulfoxide/magnesium exchange reaction be used, but it also provides a possibility to generate Grignard reagents in way that avoids metallic magnesium and thus radical processes. Therefore, enantiomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5d9e33ba92adeae3f024f5562849029
https://doi.org/10.1002/(sici)1521-3773(19990201)38:3<338::aid-anie338>3.0.co
https://doi.org/10.1002/(sici)1521-3773(19990201)38:3<338::aid-anie338>3.0.co
Autor:
Peter G. Nell
Publikováno v:
New Journal of Chemistry. 23:973-975
The α-phenylthio-substituted Grignard reagent 8 was generated in >95% ee by a sulfoxide/magnesium exchange reaction starting from the enantio- and diasteromerically pure α-phenylthio sulfoxide 6a. The α-thio-substituted Grignard reagenthas been tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb8ad19240e57dd93e3df4c6472b71a4
https://doi.org/10.1039/a906179g
https://doi.org/10.1039/a906179g
Autor:
Paul A, Wender, Jeremy L, Baryza, Chad E, Bennett, F Christopher, Bi, Stacey E, Brenner, Michael O, Clarke, Joshua C, Horan, Cindy, Kan, Emmanuel, Lacôte, Blaise, Lippa, Peter G, Nell, Tim M, Turner
Publikováno v:
Journal of the American Chemical Society. 124(46)
Macrocycle 1 is a new highly potent analogue of bryostatin 1, a promising anti-cancer agent currently in human clinical trials. In vitro, 1 displays picomolar affinity for PKC and exhibits over 100-fold greater potency than bryostatin 1 when tested a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::441645756c46ba1c788ca1741a91940f
https://pubmed.ncbi.nlm.nih.gov/12431074
https://pubmed.ncbi.nlm.nih.gov/12431074
Autor:
Reinhard W, Hoffmann, Peter G, Nell
Publikováno v:
Angewandte Chemie (International ed. in English). 38(3)
Not only for ligand exchange at sulfoxides can the sulfoxide/magnesium exchange reaction be used, but it also provides a possibility to generate Grignard reagents in way that avoids metallic magnesium and thus radical processes. Therefore, enantiomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3c7e4ec44fd8edaddfdb888ae9c7632b
https://pubmed.ncbi.nlm.nih.gov/29711667
https://pubmed.ncbi.nlm.nih.gov/29711667
Autor:
Emmanuel Lacôte, Paul A. Wender, F. Christopher Bi, Michael O. Clarke, Stacey E. Brenner, Jeremy L. Baryza, Blaise Lippa, Chad E. Bennett, Peter G Nell, Turner Timothy M, Joshua C. Horan, Cindy Kan
Publikováno v:
Journal of the American Chemical Society. 124:13648-13649
Macrocycle 1 is a new highly potent analogue of bryostatin 1, a promising anti-cancer agent currently in human clinical trials. In vitro, 1 displays picomolar affinity for PKC and exhibits over 100-fold greater potency than bryostatin 1 when tested a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39d9740e495d813840e425906288c627
https://doi.org/10.1021/ja027509+
https://doi.org/10.1021/ja027509+