Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Peter G. McLean"'
Autor:
Peter G. McLean, Andrew R. Calver, David H. Alpers, Stephen M. Collins, Fergus Shanahan, Kevin Lee
Publikováno v:
Gastroenterology Insights, Vol 1, Iss 1, Pp e3-e3 (2009)
The gastrointestinal tract and its associated mucosal immune system have been extensively studied in the context of their involvement in disease processes, both within the tract itself and in its associated organs. However, historically a number of a
Externí odkaz:
https://doaj.org/article/064465900deb47b78ab823426c69e654
Autor:
Peter G. McLean, S Christodoulides, Peter I. Duncan, Eirini Dimidi, Gabriela Bergonzelli, Kevin Whelan, Rafael Crabbe, Nashmil Emami, Shiva Taheri, C. Antonio De Castro, S. Mark Scott, Ausra Zdanaviciene, Petra Louis
Publikováno v:
Dimidi, E, Zdanaviciene, A, Christodoulides, S, Taheri, S, Louis, P, Duncan, P I, Emami, N, Crabbé, R, De Castro, C A, Mclean, P, Bergonzelli, G E, Whelan, K & Mark Scott, S 2019, ' Randomised clinical trial : Bifidobacterium lactis NCC2818 probiotic vs placebo, and impact on gut transit time, symptoms, and gut microbiology in chronic constipation ', Alimentary Pharmacology & Therapeutics, vol. 49, no. 3 . https://doi.org/10.1111/apt.15073
BackgroundConstipation is a prevalent gastrointestinal disorder. Patient dissatisfaction with prescribed medications is common, and there is need for alternative management strategies. Evidence shows that Bifidobacterium species may be beneficial in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3955780682a2d5197f7d8557616605bd
https://doi.org/10.1111/apt.15073
https://doi.org/10.1111/apt.15073
Autor:
Josh D. Neufeld, Marc Pigrau Pastor, Michael G. Surette, Pedro M. Miranda, Maria Ines Pinto-Sanchez, Michael D. Lynch, Philip Britz-McKibbin, Vivek Philip, Jun Lu, Jennifer Jury, Moreno-Gabriel Hagelsieb, Sacha Sidani, Premysl Bercik, Yikang Deng, Giada De Palma, Stephen M. Collins, Genevieve Umeh, Peter G. McLean, Gabriela Bergonzelli, Vi T Dang, Elena F. Verdu
Publikováno v:
Science Translational Medicine. 9
Irritable bowel syndrome (IBS) is a common disorder characterized by altered gut function and often is accompanied by comorbid anxiety. Although changes in the gut microbiota have been documented, their relevance to the clinical expression of IBS is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06566a6c3034642b47fc34bdea1111f6
https://doi.org/10.1126/scitranslmed.aaf6397
https://doi.org/10.1126/scitranslmed.aaf6397
Autor:
A. Khoshdel, Premysl Bercik, Yikang Deng, Peter G. McLean, Jan D. Huizinga, Deborah Moine, David A. Sinclair, Bernard Berger, Xianxi Huang, Margaret Fahnestock, Jun Lu, Amber J. Park, Stephen M. Collins, Wolfgang Kunze, Elena F. Verdu, Patricia Blennerhassett, Gabriela Bergonzelli
Publikováno v:
Neurogastroenterology & Motility. 23:1132-1139
The probiotic Bifidobacterium longum NCC3001 normalizes anxiety-like behavior and hippocampal brain derived neurotrophic factor (BDNF) in mice with infectious colitis. Using a model of chemical colitis we test whether the anxiolytic effect of B. long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6caffcd155625c6024672b71ef36661
https://doi.org/10.1111/j.1365-2982.2011.01796.x
https://doi.org/10.1111/j.1365-2982.2011.01796.x
Autor:
Aoife Quinlan, John MacSharry, Peter G. McLean, Andrea C. Haynes, Gerard M. Moloney, Kenneth Nally, Fergus Shanahan, Kevin Lee, Silvia Melgar, Carola T. Murphy, Emilie Faivre, Liam O'Mahony
Publikováno v:
Journal of Leukocyte Biology. 88:1271-1278
Method for in vivo bioluminescence imaging as a valuable strategy for pre-clinical evaluation of leukocyte trafficking as shown here for small molecule α4-integrin antagonists as a promising therapeutic for IBD. Leukocyte trafficking is a therapeuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb20cc2e932d2b9f78a72689b6d9b26
https://doi.org/10.1189/jlb.0909627
https://doi.org/10.1189/jlb.0909627
Publikováno v:
European Journal of Pharmacology. 589:260-263
Identification of novel drug molecules requires the extensive evaluation in vitro and in vivo. Following in vitro evaluation it is necessary to efficiently screen numerous novel molecules in vivo using relatively simple methodology that requires smal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295a3cbb5f651a92e14d95cbf5250d98
https://doi.org/10.1016/j.ejphar.2008.05.026
https://doi.org/10.1016/j.ejphar.2008.05.026
Autor:
Muriel H. Larauche, Yvette Taché, James A. McRoberts, Peter G. McLean, Emeran A. Mayer, Mulugeta Million, Sylvie Bradesi
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 294:G1033-G1040
Visceral hypersensitivity has been implicated as an important pathophysiological mechanism in functional gastrointestinal disorders. In this study, we investigated whether the sustained visceral hyperalgesia induced by repeated psychological stress i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf50ecb30ed4ea626d8bcc0a0948f81
https://doi.org/10.1152/ajpgi.00507.2007
https://doi.org/10.1152/ajpgi.00507.2007
Autor:
Peter G. McLean, Lijun Lao, Kevin Lee, Emeran A. Mayer, Wendy J. Winchester, Sylvie Bradesi, Gareth A. Hicks
Publikováno v:
Pain. 130:56-65
Despite its beneficial effect in IBS patients, the mechanism of action of the 5-HT3 receptor (5-HT3R) antagonist alosetron is still incompletely understood. We aimed to characterize the effect and site(s) of action in a model of stress-induced sensit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dba4669b86e051822782bdf1aecacf2
https://doi.org/10.1016/j.pain.2006.10.028
https://doi.org/10.1016/j.pain.2006.10.028
Publikováno v:
Trends in Neurosciences. 30:9-13
In recent times, the perception of functional gastrointestinal disorders such as irritable bowel syndrome (IBS) has shifted fundamentally. Such disorders are now thought of as serious diseases characterized by perturbations in the neuronal regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be64aeb0c76aba873b1eaf3a4c99c5d
https://doi.org/10.1016/j.tins.2006.11.002
https://doi.org/10.1016/j.tins.2006.11.002
Publikováno v:
Pain. 126:54-63
Conflicting results exist regarding the role of 5-HT3 receptors in somatic and visceral nociceptive processing. We aimed to investigate the effects of the 5-HT3 receptor antagonist, alosetron, in a rat model of somatic and visceral hyperalgesia. Two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ce5201abc2a1ec4444978c2ae02e97
https://doi.org/10.1016/j.pain.2006.06.014
https://doi.org/10.1016/j.pain.2006.06.014