Výsledky vyhledávání - "Peter G. Hawkins"

Akademický článek

Designing meaningful continuous representations of T cell receptor sequences with deep generative models

Autor: Allen Y. Leary, Darius Scott, Namita T. Gupta, Janelle C. Waite, Dimitris Skokos, Gurinder S. Atwal, Peter G. Hawkins

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)

Abstract T Cell Receptor (TCR) antigen binding underlies a key mechanism of the adaptive immune response yet the vast diversity of TCRs and the complexity of protein interactions limits our ability to build useful low dimensional representations of T

Externí odkaz: https://doaj.org/article/1820b41f4a474b529dd9e7094a5d49f9

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Akademický článek

Imaging response assessment for predicting outcomes after bioselection chemotherapy in larynx cancer: A secondary analysis of two prospective trials

Publikováno v: Clinical and Translational Radiation Oncology, Vol 33, Iss , Pp 30-36 (2022)

Background and purpose: Bioselection with induction chemotherapy in larynx cancer is associated with excellent larynx preservation and disease-specific survival but requires visual inspection of the primary tumor. We retrospectively compare clinical

Externí odkaz: https://doaj.org/article/36489a02909c47fdb394460ab8d41d1e

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Akademický článek

Prediction of Radiation Esophagitis in Non–Small Cell Lung Cancer Using Clinical Factors, Dosimetric Parameters, and Pretreatment Cytokine Levels

Autor: Peter G. Hawkins, Philip S. Boonstra, Stephen T. Hobson, James A. Hayman, Randall K. Ten Haken, Martha M. Matuszak, Paul Stanton, Gregory P. Kalemkerian, Theodore S. Lawrence, Matthew J. Schipper, Feng-Ming (Spring) Kong, Shruti Jolly

Publikováno v: Translational Oncology, Vol 11, Iss 1, Pp 102-108 (2018)

Radiation esophagitis (RE) is a common adverse event associated with radiotherapy for non–small cell lung cancer (NSCLC). While plasma cytokine levels have been correlated with other forms of radiation-induced toxicity, their association with RE ha

Externí odkaz: https://doaj.org/article/807aa9f845534e57980033eb1a73c236

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Akademický článek

Predictive Values of MRI and PET Derived Quantitative Parameters for Patterns of Failure in Both p16+ and p16– High Risk Head and Neck Cancer

Autor: Yue Cao, Madhava Aryal, Pin Li, Choonik Lee, Matthew Schipper, Peter G. Hawkins, Christina Chapman, Dawn Owen, Aleksandar F. Dragovic, Paul Swiecicki, Keith Casper, Francis Worden, Theodore S. Lawrence, Avraham Eisbruch, Michelle Mierzwa

Publikováno v: Frontiers in Oncology, Vol 9 (2019)

Purpose: FDG-PET adds to clinical factors, such tumor stage and p16 status, in predicting local (LF), regional (RF), and distant failure (DF) in poor prognosis locally advanced head and neck cancer (HNC) treated with chemoradiation. We hypothesized t

Externí odkaz: https://doaj.org/article/d537189ae9b74d1fbaf1e24cebc31b02

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Imaging response assessment for predicting outcomes after bioselection chemotherapy in larynx cancer: A secondary analysis of two prospective trials

Publikováno v: Clinical and Translational Radiation Oncology
Clinical and Translational Radiation Oncology, Vol 33, Iss, Pp 30-36 (2022)

Highlights • Bioselection with induction chemotherapy in larynx cancer has good outcomes but has challenges. • CT imaging is complementary to surgeon assessment of response and may be incorporated. • Imaging features predict for surgeon assessm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30bb5e53eda8e5f65d26f025827d09e6
https://pubmed.ncbi.nlm.nih.gov/35024462

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Predictive Models to Determine Clinically Relevant Deviations in Delivered Dose for Head and Neck Cancer

Autor: Daniel F. Polan, Molly M. McCulloch, Jan-Jakob Sonke, Chrissy M. Lockhart, Carlos J. R. Anderson, James M. Balter, Avraham Eisbruch, Kristy K. Brock, Clifton D. Fuller, J. Heukelom, Justin D. Kamp, Jae Y. Lee, Randall K. Ten Haken, B.S. Rosen, Peter G. Hawkins, Choonik Lee

Publikováno v: Pract Radiat Oncol

Purpose This study aimed to improve the understanding of deviations between planned and accumulated doses and to establish metrics to predict clinically significant dosimetric deviations midway through treatment to evaluate the potential need to re-p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287fda85b006c4bf9fc91b76af917d55
https://doi.org/10.1016/j.prro.2019.02.014

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Real-Time Quantitative Assessment of Accuracy and Precision of Blood Volume Derived from DCE-MRI in Individual Patients During a Clinical Trial

Autor: Michelle Mierzwa, Peter G. Hawkins, Yue Cao, Avraham Eisbruch, Christina H. Chapman, Madhava P. Aryal, Choonik Lee

Publikováno v: Tomography
Volume 5
Issue 1
Pages 61-67
Tomography; Volume 5; Issue 1; Pages: 61-67

Accuracy and precision of quantitative imaging (QI) metrics should be assessed in real time in each patient during a clinical trial to support QI-based decision-making. We developed a framework for real-time quantitative assessment of QI metrics and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a60dbe7fe8fb333f80f7e2b57f048eb
http://europepmc.org/articles/PMC6403042

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Submandibular gland sparing when irradiating neck level IB in the treatment of oral squamous cell carcinoma

Autor: Charles S. Mayo, Peter G. Hawkins, John Yao, George S. Arnould, Michelle Mierzwa, William C. Jackson

Publikováno v: Medical Dosimetry. 44:144-149

Patients with oral squamous cell carcinoma (OSqCCA) frequently require postoperative radiation (PORT), which may include contralateral level IB within the clinical target volume (CTV). The submandibular gland (SMG) is typically included within the le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3102047ae12ebbea12aa23218f7d470d
https://doi.org/10.1016/j.meddos.2018.04.003

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A framework for highly multiplexed dextramer mapping and prediction of T cell receptor sequences to antigen specificity

Autor: Gabrielle Choonoo, Wen Zhang, Jing He, Raquel Deering, Namita Gupta, Jinrui Liu, Gavin Thurston, Ankur Dhanik, Se W. Jeong, Calvin R. Chen, Peter G. Hawkins, Gurinder S. Atwal, Myles Dillon, Macdonald Lynn

Publikováno v: Science Advances

A computational framework expedites the identification and prediction of T cell antigen recognition.
T cell receptor (TCR) antigen–specific recognition is essential for the adaptive immune system. However, building a TCR-antigen interaction ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e372cf2eb84562bfaa248d1b9fbf4351
https://pubmed.ncbi.nlm.nih.gov/33990328

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Early MRI Blood Volume Changes in Constrictor Muscles Correlate With Postradiation Dysphagia

Autor: Christina H. Chapman, Anna Blakely, Matthew J. Schipper, C.A. Schonewolf, J.L. Shah, Madhava P. Aryal, Teresa Lyden, Peter G. Hawkins, J.R. Wilkie, Choonik Lee, Yue Cao, Michelle Mierzwa, Avraham Eisbruch, B.S. Rosen, L.A. Gharzai, Pin Li, Jennifer Thamarus

Publikováno v: International journal of radiation oncology, biology, physics. 110(2)

Predicting individual patient sensitivity to radiation therapy (RT) for tumor control or normal tissue toxicity is necessary to individualize treatment planning. In head and neck cancer, radiation doses are limited by many nearby critical structures,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25eaaefdab40e7b1cfe965b3b6c7357a
https://pubmed.ncbi.nlm.nih.gov/33346093

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