Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Peter G. Foiles"'
Publikováno v:
Carcinogenesis. 17:1127-1134
The metabolism of N-nitrosodimethylamine (NDMA) and its methylation of DNA were simultaneously determined in hepatocytes isolated from untreated and saline- and pyrazole-treated male Sprague-Dawley rats. Metabolism of NDMA was directly measured by mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5921b10fc7cd2d44390a00dfa3ac9575
https://doi.org/10.1093/carcin/17.5.1127
https://doi.org/10.1093/carcin/17.5.1127
Publikováno v:
Chemical Research in Toxicology. 9:563-567
The preparation of sequence and groove specific DNA methylating agents based on N-methylpyrrolecarboxamide subunits appended with an O-methyl sulfonate ester functionality (MeOSO2(CH2)2-Lex) has previously been described [Zhang, Y., Chen, F.-X., Meht
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d847c0af8793f46671e1f9a8a23c5c0
https://doi.org/10.1021/tx9501849
https://doi.org/10.1021/tx9501849
Publikováno v:
Environmental Health Perspectives
This paper describes quantitation of human hemoglobin and DNA adducts of the carcinogenic tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N'-nitrosonornicotine (NNN). NNK and NNN are believed to be involved in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a81741d38aaaf19eb182d8241742c8
https://doi.org/10.1289/ehp.939957
https://doi.org/10.1289/ehp.939957
Publikováno v:
Journal of Cellular Biochemistry. 53:27-35
Smoking is the major cause of upper aerodigestive tract cancers. Among the many constituents of tobacco smoke, polynuclear aromatic hydrocarbons and tobacco-specific nitrosamines are strongly implicated as causative factors for these cancers. The pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6dcb9afddde0f18edc4606bba72e0a8
https://doi.org/10.1002/jcb.240531005
https://doi.org/10.1002/jcb.240531005
Autor:
Stephen S. Hecht, Shobha A. Akerkar, Mark Kagan, Peter G. Foiles, Steven G. Carmella, Gary D. Stoner, James H. Resau
Publikováno v:
Chemical Research in Toxicology. 4:364-368
A gas chromatography, negative ion chemical ionization mass spectrometry (GC-NICI-MS) based assay for tobacco-specific nitrosamine adducts of DNA is described. The assay is based on the observation that acid hydrolysis of DNA from animals treated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026a799510d2a68ea9bd3d3841378178
https://doi.org/10.1021/tx00021a017
https://doi.org/10.1021/tx00021a017
Autor:
Anthony A. Frank, Vincent L. Wilson, Fung-Lung Chung, Andrew C. Povey, Curtis C. Harris, Peter G. Foiles
Publikováno v:
Carcinogenesis. 12:1483-1490
People are constantly being exposed to toxic and carcinogenic aldehydes. However, little is actually known about the mechanisms underlying the toxic and carcinogenic effects of these aldehydes on human cells. The DNA alkylating activities of two of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::880b775be3e6c8f22dfa23f38dcb64b6
https://doi.org/10.1093/carcin/12.8.1483
https://doi.org/10.1093/carcin/12.8.1483
Publikováno v:
Carcinogenesis. 11:2059-2061
Acrolein and crotonaldehyde are alpha,beta-unsaturated carbonyl compounds that form 1,N2-propanodeoxyguanosine adducts when reacted with DNA in vitro. These compounds are mutagenic in Salmonella, and crotonaldehyde is tumorigenic in rats. This study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7be852b7b0bd50b4a74ebd80bfe5d4b
https://doi.org/10.1093/carcin/11.11.2059
https://doi.org/10.1093/carcin/11.11.2059
Autor:
J.T. Kuśmierek, Peter G. Foiles, Akiyoshi Nishikawa, Brett C. Singer, Lisa M. Miglietta, Fung-Lung Chung
Publikováno v:
Carcinogenesis. 14(1)
Monoclonal antibodies specific for N2,3-ethenodeoxyguanosine (N2,3-epsilon dGuo) and 1,N2-ethenodeoxyguanosine (1,N2-epsilon dGuo) were developed. In a competitive ELISA, 50% inhibition of binding of the N2,3-epsilon dGuo specific antibody (ETH1) was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91696fc1dd4cc403175e4c0f414259dc
https://pubmed.ncbi.nlm.nih.gov/8425258
https://pubmed.ncbi.nlm.nih.gov/8425258
Publikováno v:
Molecular carcinogenesis. 7(1)
We previously identified an ultraviolet (UV)-responsive element (URE; TGACAACA) that plays a role in both transcription and replication of polyoma sequences. Mouse polyclonal antibodies were raised against affinity-purified URE-bound proteins to char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0b18c11ea6d7a3cc18d32152d1ff7f
https://pubmed.ncbi.nlm.nih.gov/8435108
https://pubmed.ncbi.nlm.nih.gov/8435108
Publikováno v:
Mutation research. 279(2)
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) requires metabolic activation to express its carcinogenic activity. This activation leads to the formation of methylating and pyridyloxobutylating agents. To determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d664a6255119aca459414fad11cae0d6
https://pubmed.ncbi.nlm.nih.gov/1375343
https://pubmed.ncbi.nlm.nih.gov/1375343