Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Peter G. Dodd"'
Autor:
Kate McGonagle, Gary J. Tarver, Juan Cantizani, Ignacio Cotillo, Peter G. Dodd, Liam Ferguson, Ian H. Gilbert, Maria Marco, Tim Miles, Claire Naylor, Maria Osuna-Cabello, Christy Paterson, Kevin D. Read, Erika G. Pinto, Jennifer Riley, Paul Scullion, Yoko Shishikura, Frederick Simeons, Laste Stojanovski, Nina Svensen, John Thomas, Paul G. Wyatt, Pilar Manzano, Manu De Rycker, Michael G. Thomas
Publikováno v:
European Journal of Medicinal Chemistry. 238:114421
Approximately 6-7 million people around the world are estimated to be infected with Trypanosoma cruzi, the causative agent of Chagas disease. The current treatments are inadequate and therefore new medical interventions are urgently needed. In this p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86bf125287545c773f53bf39897b9bb5
https://doi.org/10.1016/j.ejmech.2022.114421
https://doi.org/10.1016/j.ejmech.2022.114421
Publikováno v:
Mudd, G, Pi, I P, Fethers, N, Dodd, P G, Barbeau, O R & Auer, M 2015, ' A general synthetic route to isomerically pure functionalized rhodamine dyes ', Methods and Applications in Fluorescence, vol. 3, no. 4, 045002 . https://doi.org/10.1088/2050-6120/3/4/045002
A well-documented obstacle in the synthesis of functionalized rhodamine dyes is the generation of regioisomers which are difficult to separate. These isomers occur due to the use of unsymmetrical anhydride reagents, which possess two potential points
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caacf6dcbc37a1a2f0d09126efe2ffbb
https://pubmed.ncbi.nlm.nih.gov/29148510
https://pubmed.ncbi.nlm.nih.gov/29148510
Autor:
Peter G. Dodd, Thomas Ryckmans, Samantha Hughes, David G. Brown, Martin P. Green, Andrew Simon Bell, Willem P. van Hoorn, Christopher A. Hewson, Christopher Phillips, Philip Cohen, Lyn H. Jones, Iain Kilty, Robert T. Smith
Publikováno v:
Chemical Biology & Drug Design. 82:500-505
The first example of an inhibitor of the kinase TAK1 that binds in the DFG-out conformation is disclosed. These preliminary studies used kinase-targeted screening and structure-based drug design to create a molecule with dual pharmacological inhibiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0465c3bf1d741bb2e3057818672ba1a
https://doi.org/10.1111/cbdd.12169
https://doi.org/10.1111/cbdd.12169
Autor:
Owen Everson, Tram T. Tran, Emily J. S. Graham, Florian Wakenhut, Paul Targett-Adams, Jared Millbank, David M. Beal, Lyn H. Jones, Matthew D. Selby, George M. Burslem, Peter G. Dodd
Publikováno v:
Journal of Chemical Biology. 4:49-53
Small molecule fluorometric boron dipyrromethene probes were developed to bind hepatitis C virus-encoded NS5A protein and aid subcellular distribution studies. These molecules did not co-locate with NS5A, therefore alternative 'silent' azide reporter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c61f9cdb1e900ddd76f1a0a2b58161d
https://doi.org/10.1007/s12154-010-0047-1
https://doi.org/10.1007/s12154-010-0047-1
Autor:
William A. Million, Pauline Carnell, Gareth W. Harbottle, Russell Monhemius, Simon A. Osborne, Cedric Poinsard, Maw Graham Nigel, Ben S. Greener, Karl Richard Gibson, Rebecca L. Prime, Steven England, Peter G. Dodd, Simon John Mantell, Alison Betts, Huw Rees
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2190-2194
The SAR of a series of novel pyrido[3,4-d]pyramid-4-ylamine mGluR1 antagonists is described. The multiple of the unbound K(i) in cerebrospinal fluid necessary to give morphine like analgesic effects in an electromyograph pinch model in rodents is det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedc2e644ebe905bda97f0d735bbb991
https://doi.org/10.1016/j.bmcl.2009.02.106
https://doi.org/10.1016/j.bmcl.2009.02.106
Autor:
D. K. Walker, Emilio F. Stuart, Arnaud Lemaitre, David V. Batchelor, Peter G. Dodd, Maw Graham Nigel, Helene Chavaroche, Sandra Marina Monaghan, Ruth F. Keir, Matthew D. Selby, Simon John Mantell, Tim J. Hobson, Michael A. Trevethick, Peter T. Stephenson, Stuart Rozze, Rhys M. Jones, Karen N. Wright, Michael Yeadon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1284-1287
COPD is a major cause of mortality in the western world. A(2A) agonists are postulated to reduce the lung inflammation that causes COPD. The cardiovascular effects of A(2A) agonists dictate that a compound needs to be delivered by inhalation to be th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d0869ceb904523cd82b828bbd710e4
https://doi.org/10.1016/j.bmcl.2008.01.033
https://doi.org/10.1016/j.bmcl.2008.01.033
Autor:
Simon Gayton, Graham Smith, Dafydd R. Owen, Gareth W. Harbottle, Tracy J. Ringer, Maw Graham Nigel, Simon A. Osborne, Margarita Rodriguez-Lens, Huw Rees, Peter G. Dodd, Ben S. Greener, Simon John Mantell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:486-490
A series of novel mGluR1 antagonists have been prepared. Incorporation of fragments derived from weak lead matter into a library led to enhanced potency in a new chemical series. A chemistry driven second library iteration, covering a greatly enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9542eb7964fd6a3b5aa1b6c9a6e4b0a
https://doi.org/10.1016/j.bmcl.2006.10.015
https://doi.org/10.1016/j.bmcl.2006.10.015
Autor:
Robert T. Smith, Jane L. Burrows, Arnaud Lemaitre, Samantha Hughes, Peter G. Dodd, Tim J. Evans, Russell Andrew Lewthwaite, Mathias John Paul, Mark H. Stefaniak, Michael Yeadon, James Philip, David S. Millan, Mark E. Bunnage, Christopher Phillips, Kenneth John Butcher, Iain Kilty, David Fairman, Axel Mahnke
Publikováno v:
Journal of medicinal chemistry. 54(22)
This paper describes the identification and optimization of a novel series of DFG-out binding p38 inhibitors as inhaled agents for the treatment of chronic obstructive pulmonary disease. Structure based drug design and "inhalation by design" principl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0cff411c95d8e91f42d706bb7fab72f
https://pubmed.ncbi.nlm.nih.gov/21888439
https://pubmed.ncbi.nlm.nih.gov/21888439
Publikováno v:
SAE Technical Paper Series.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94b88cee8b09994f8699e1b7a72649be
https://doi.org/10.4271/981170
https://doi.org/10.4271/981170
Autor:
David S. Millan, Mark E. Bunnage, Jane L. Burrows, Kenneth J. Butcher, Peter G. Dodd, Timothy J. Evans, David A. Fairman, Samantha J. Hughes, Iain C. Kilty, Arnaud Lemaitre, Russell A. Lewthwaite, Axel Mahnke, John P. Mathias, James Philip, Robert T. Smith, Mark H. Stefaniak, Michael Yeadon, Christopher Phillips
Publikováno v:
Journal of Medicinal Chemistry; Nov2011, Vol. 54 Issue 22, p7797-7814, 18p