Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Peter G. Barr-Gillespie"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract ATP-utilizing enzymes play key roles in hair bundles, the mechanically sensitive organelles of sensory hair cells in the inner ear. We used a fluorescent ATP analog, EDA-ATP-Cy3 (Cy3-ATP), to label ATP-binding proteins in two different prepa
Externí odkaz:
https://doaj.org/article/ea838ab1079a4e2ab400aa3abf62f3cf
Autor:
Seham Ebrahim, Matthew R. Avenarius, M’hamed Grati, Jocelyn F. Krey, Alanna M. Windsor, Aurea D. Sousa, Angela Ballesteros, Runjia Cui, Bryan A. Millis, Felipe T. Salles, Michelle A. Baird, Michael W. Davidson, Sherri M. Jones, Dongseok Choi, Lijin Dong, Manmeet H. Raval, Christopher M. Yengo, Peter G. Barr-Gillespie, Bechara Kachar
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
Stereocilia of the inner ear have graded heights that are thought to be regulated by the myosin-III family members MYO3A and MYO3B. Here the authors identify espin-1 and espin-like (ESPNL) as cargo that differentially influence the functions of both
Externí odkaz:
https://doaj.org/article/42f55193d572437c9f31dff7d2836595
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Mammalian hearing is remarkable for its sensitivity and frequency selectivity. Here, the authors show that outer hair cell-generated force, which amplifies sound-induced vibrations inside the cochlea, is responsible for these traits.
Externí odkaz:
https://doaj.org/article/09a80e5c303e418a99fef9880e10a845
Autor:
Clive P. Morgan, Hongyu Zhao, Meredith LeMasurier, Wei Xiong, Bifeng Pan, Piotr Kazmierczak, Matthew R. Avenarius, Michael Bateschell, Ruby Larisch, Anthony J. Ricci, Ulrich Müller, Peter G. Barr-Gillespie
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Hair cells of the inner ear transduce mechanical stimuli like sound or head movements into electrical signals, which are propagated to the central nervous system. The hair-cell mechanotransduction channel remains unidentified. We tested whether three
Externí odkaz:
https://doaj.org/article/d575ed1e6a8c4635817fbfe708a330e9
Autor:
Seham Ebrahim, Matthew R. Avenarius, M’hamed Grati, Jocelyn F. Krey, Alanna M. Windsor, Aurea D. Sousa, Angela Ballesteros, Runjia Cui, Bryan A. Millis, Felipe T. Salles, Michelle A. Baird, Michael W. Davidson, Sherri M. Jones, Dongseok Choi, Lijin Dong, Manmeet H. Raval, Christopher M. Yengo, Peter G. Barr-Gillespie, Bechara Kachar
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 7 Article number: 10833 (2016). Published 1 March 2016; Updated 14 August 2017 Technical support for this Article was not fully acknowledged. The Acknowledgements should have included the following: We thank Drs Ronald Petralia
Externí odkaz:
https://doaj.org/article/7ab50f15fa284f74870f3ed28d5085a5
Autor:
Jocelyn F Krey, Paroma Chatterjee, Julia Halford, Christopher L Cunningham, Benjamin J Perrin, Peter G Barr-Gillespie
Publikováno v:
PLoS Biology, Vol 21, Iss 4, p e3001964 (2023)
Assembly of the hair bundle, the sensory organelle of the inner ear, depends on differential growth of actin-based stereocilia. Separate rows of stereocilia, labeled 1 through 3 from tallest to shortest, lengthen or shorten during discrete time inter
Externí odkaz:
https://doaj.org/article/440e5a05d7284be28e2aa50c2c5407a5
Autor:
Ying Zhu, Mirko Scheibinger, Daniel Christian Ellwanger, Jocelyn F Krey, Dongseok Choi, Ryan T Kelly, Stefan Heller, Peter G Barr-Gillespie
Publikováno v:
eLife, Vol 8 (2019)
Hearing and balance rely on small sensory hair cells that reside in the inner ear. To explore dynamic changes in the abundant proteins present in differentiating hair cells, we used nanoliter-scale shotgun mass spectrometry of single cells, each ~1 p
Externí odkaz:
https://doaj.org/article/19e6a3669263492e9fe408c93b8d336a
Autor:
Vladimir Vartanian, Jocelyn F. Krey, Paroma Chatterjee, Sherri M. Jones, Allison Curtis, Renee Ryals, R. Stephen Lloyd, Peter G. Barr-Gillespie
Strategies to reveal the discovery of the relationships between novel phenotypic behaviors and specific genetic alterations can be achieved via either target-specific, directed mutagenesis or phenotypic selection following random chemical mutagenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16187f36244b5daed525783bd6d6b47b
https://doi.org/10.1101/2023.02.28.529432
https://doi.org/10.1101/2023.02.28.529432
Autor:
Timothy Erickson, Clive P Morgan, Jennifer Olt, Katherine Hardy, Elisabeth Busch-Nentwich, Reo Maeda, Rachel Clemens, Jocelyn F Krey, Alex Nechiporuk, Peter G Barr-Gillespie, Walter Marcotti, Teresa Nicolson
Publikováno v:
eLife, Vol 6 (2017)
Transmembrane O-methyltransferase (TOMT/LRTOMT) is responsible for non-syndromic deafness DFNB63. However, the specific defects that lead to hearing loss have not been described. Using a zebrafish model of DFNB63, we show that the auditory and vestib
Externí odkaz:
https://doaj.org/article/8c67b3aa4fc342c1bcf127fb9e97b312
Publikováno v:
Molecular Biology of the Cell. 33
Many proteins are directed to specific locations within the cell. Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2, a membrane-binding protein required for maintenance of mechanotransduction in hair cells, is selectively ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56f9ce99bd5ebe87cbf280a62a47f3a8
https://doi.org/10.1091/mbc.e21-10-0491
https://doi.org/10.1091/mbc.e21-10-0491