Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Peter G Noakes"'
Autor:
Nicola Ferreira, Christopher E Andoniou, Kara L Perks, Judith A Ermer, Danielle L Rudler, Giulia Rossetti, Ambika Periyakaruppiah, Jamie K Y Wong, Oliver Rackham, Peter G Noakes, Mariapia A Degli-Esposti, Aleksandra Filipovska
Publikováno v:
PLoS Genetics, Vol 16, Iss 3, p e1008604 (2020)
The influence of environmental insults on the onset and progression of mitochondrial diseases is unknown. To evaluate the effects of infection on mitochondrial disease we used a mouse model of Leigh Syndrome, where a missense mutation in the Taco1 ge
Externí odkaz:
https://doaj.org/article/4c2f6a2af5f1410aad89e487d9251e55
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106614- (2024)
Perineuronal nets (PNNs) are extracellular matrix structures that surround excitable neurons and their proximal dendrites. PNNs play an important role in neuroprotection against oxidative stress. Oxidative stress within motor neurons can act as a tri
Externí odkaz:
https://doaj.org/article/9b188baf16d24c7cb9c3cb629ea735bb
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
In amyotrophic lateral sclerosis (ALS) postmortem tissue and the SOD1 mouse model at mid-disease, death of hypoglossal motor neurons (XII MNs) is evident. These XII MNs innervate the intrinsic and extrinsic tongue muscles, and despite their importanc
Externí odkaz:
https://doaj.org/article/200989ceacc844b09f2bd1a936ff92f2
Autor:
Matthew J Fogarty, Karen L Smallcombe, Yuchio Yanagawa, Kunihiko Obata, Mark C Bellingham, Peter G Noakes
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56257 (2013)
Central nervous system GABAergic and glycinergic synaptic activity switches from postsynaptic excitation to inhibition during the stage when motor neuron numbers are being reduced, and when synaptic connections are being established onto and by motor
Externí odkaz:
https://doaj.org/article/2635884d15ea4b59a7cf284c940a482b
Autor:
Bahaa Al-mhanawi, Marta Boira Marti, Sean D. Morrison, Pallavi Gupta, Maath Alani, Peter G. Noakes, Ernst J. Wolvetang, Mohammed R. Shaker
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102725- (2023)
Summary: In response to the scarcity of advanced in vitro models dedicated to human CNS white matter research, we present a protocol to generate neuroectoderm-derived embedding-free human brain organoids enriched with oligodendrocytes. We describe st
Externí odkaz:
https://doaj.org/article/0dbd36b24b054391aee45e705a19e472
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 912 (2023)
It has been hypothesised that inhalational anaesthetics such as isoflurane (Iso) may trigger the pathogenesis of Alzheimer’s disease (AD), while the gaseous anaesthetic xenon (Xe) exhibits many features of a putative neuroprotective agent. Loss of
Externí odkaz:
https://doaj.org/article/f9f90fcfe14e4f20bf475209858386a5
Autor:
Kirat K. Chand, Kah Meng Lee, Nickolas A. Lavidis, Manuel Rodriguez-Valle, Hina Ijaz, Johannes Koehbach, Richard J. Clark, Ala Lew-Tabor, Peter G. Noakes
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/1422b4e514b4457f84631a3e5f573c5f
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7965 (2022)
Normal development and function of the central nervous system involves a balance between excitatory and inhibitory neurotransmission. Activity of both excitatory and inhibitory neurons is modulated by inhibitory signalling of the GABAergic and glycin
Externí odkaz:
https://doaj.org/article/02dbf85f2e894f94b4a67599f87fe5e7
Autor:
Peter G. Noakes, William D. Phillips, Rosalind L. Jeffree, Frederik J. Steyn, Ernst J. Wolvetang, Rob D. Henderson, Pamela A. McCombe, Shyuan T. Ngo
Publikováno v:
Journal of Experimental Neurology. 4:1-5
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-13 (2018)
Abstract Background Components of the innate immune complement system have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS) specifically using hSOD1 transgenic animals; however, a comprehensive examination of complement expr
Externí odkaz:
https://doaj.org/article/44b8e714290847afa9c9c6c5b7c5ba39