Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Peter G Lord"'
Autor:
Eduarda M. Santos, Mark R. Viant, Peter G. Lord, Caren C. Helbing, Daniel W. Bearden, Anne O’Neill, Charles R. Tyler, Rachel C. Skirrow, Yoshi Kagami, Heather L. Osachoff, Paul F. Hoekstra, Tim Collette, Li Liu, William H. Benson, William S. Baldwin, Lorraine Yu, Terry McIntyre, Francesco Falciani, Graham van Aggelen, Michael R. Embry, Stephen G. George, David C. Volz, Taisen Iguchi, Tim D. Williams, Gerald T. Ankley, Nancy D. Denslow, J. Kevin Chipman, Peter Kille, Ed J. Perkins, Don Versteeg, John A. Craft, Ioanna Katsiadaki, Jason Snape
Publikováno v:
Environmental Health Perspectives
Background: In this commentary we present the findings from an international consortium on fish toxicogenomics sponsored by the U.K. Natural Environment Research Council (Fish Toxicogenomics—Moving into Regulation and Monitoring, held 21–23 April
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c619db30e18b7142fbefea8a28f32cf8
http://europepmc.org/articles/PMC2831950
http://europepmc.org/articles/PMC2831950
Autor:
Peter G, Lord
Publikováno v:
Toxicology Letters. 149:371-375
Genomics has had an impact on two areas of drug development, "predictive" toxicology and mechanism-based risk assessment. Predictive toxicology studies are aimed at identifying the potential for a compound to be toxic. By developing databases of expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abcaf3d59aa4115cc608852e7d1f4e04
https://doi.org/10.1016/j.toxlet.2003.12.045
https://doi.org/10.1016/j.toxlet.2003.12.045
Autor:
Nick Plant, Kathryn E. Plant, Peter G. Lord, Jon Lyon, G. Gordon Gibson, Kerstin Kramer, Sarah E Crunkhorn
Publikováno v:
Biochemical Pharmacology. 67:107-118
Many xenobiotics are known to cause liver enlargement and hepatocarcinogenesis in rats, although the molecular mechanisms that underlie this effect remain largely undefined. Human exposure to several of these compounds, including glucocorticoids and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01be3beaa1b7a5d6447ab544822057b
https://doi.org/10.1016/j.bcp.2003.09.001
https://doi.org/10.1016/j.bcp.2003.09.001
Autor:
Kerstin Kramer, Peter G. Lord, John N. Wood, Geoff Heald, Wai J. Man, Paul Cutler, Peter J. Bugelski, Ian R. White, Duncan Bryant, Patrick Camilleri
Publikováno v:
PROTEOMICS. 2:1577-1585
This study has investigated the protein changes in rat liver elicited by a group of model hepatotoxicants, methapyrilene, cyproterone acetate and dexamethasone and offers a compelling argument in support of the use of two-dimensional polyacrylamide g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78423c76bcc0f2a688d9181342ace04f
https://doi.org/10.1002/1615-9861(200211)2:11<1577::aid-prot1577>3.0.co
https://doi.org/10.1002/1615-9861(200211)2:11<1577::aid-prot1577>3.0.co
Autor:
G. Gordon Gibson, Peter G. Lord, C.-L. Cockburn, Nick Plant, E. Horner, P. Bugelski, P. Barber
Publikováno v:
Toxicology and Applied Pharmacology. 183:127-134
Sodium valproate (VPA) is clinically employed as an anticonvulsant and, to a lesser extent, as a mood stabilizer. While the incidence of toxicity associated with the clinical use of valproate is low, serious hepatotoxicity makes up a significant perc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33580ff0668c5b7bf28d2b4545e4cff0
https://doi.org/10.1006/taap.2002.9463
https://doi.org/10.1006/taap.2002.9463
Autor:
Patrick Camilleri, Peter G. Lord, Joanne Charlwood, Peter J. Bugelski, N. King, J. Mark Skehel, Uzma Atif
Publikováno v:
Journal of Proteome Research. 1:73-82
The regionally specific structure and function of the kidney renders it susceptible to toxic exposure. To characterize these changes at the proteome level, we have investigated the effects on protein expression following treatment with gentamicin.The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6892faad51a04d9363fd75261e1c8e35
https://doi.org/10.1021/pr0100063
https://doi.org/10.1021/pr0100063
Publikováno v:
Pharmaceutical Research. 17:1265-1272
Purpose. Recent advances in combinatorial chemistry and high throughput screens for pharmacologic activity have created an increasing demand for in vitrohigh throughput screens for toxicological evaluation in the early phases of drug discovery.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41b71db445fa6db9a34e798060627d4a
https://doi.org/10.1023/a:1026495503939
https://doi.org/10.1023/a:1026495503939
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 14:65-72
The molecular basis of how rodent nongenotoxic hepatocarcinogens such as phenobarbitone cause liver-tumor formation is poorly understood. An early effect of phenobarbitone exposure is to induce hepatocyte proliferation transiently, and there is evide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b06e294f706ee52f94fecba0eab6cc8b
https://doi.org/10.1002/(sici)1099-0461(2000)14:2<65::aid-jbt1>3.0.co
https://doi.org/10.1002/(sici)1099-0461(2000)14:2<65::aid-jbt1>3.0.co
Autor:
Angelique Leone, S. Jim Proctor, Geert R. Verheyen, Mark D. Johnson, Michael McMillian, L. Mark Kao, Leigh-Anne Piechta, Michael F. Kelley, Alex Nie, J. Brandon Parker, Peter G. Lord, Sharmilee Sawant
Publikováno v:
Toxicology and applied pharmacology. 275(3)
Previously we reported a gene expression signature in rat liver for detecting a specific type of oxidative stress (OS) related to reactive metabolites (RM). High doses of the drugs disulfiram, ethinyl estradiol and nimesulide were used with another d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69347aaaf400efa7d8b635ed062df927
https://pubmed.ncbi.nlm.nih.gov/24486436
https://pubmed.ncbi.nlm.nih.gov/24486436
Autor:
Peter G. Lord
The issue of data reporting standards was a topic much debated and addressed by the HL7/CDISC/I3C Toxicogenomic data submissions group, who finalized a report of its recommendations in December 2006. This vignette describes how the group created hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4466876aace50807b3a52838625a46ca
https://doi.org/10.1016/b978-0-12-391496-5.00011-9
https://doi.org/10.1016/b978-0-12-391496-5.00011-9
