Zobrazeno 1 - 10 of 129 pro vyhledávání: '"Peter G, Zaphiropoulos"'
1
Akademický článek
Identification of novel GLI1 target genes and regulatory circuits in human cancer cells
Autor: Yumei Diao, Mohammed Ferdous‐Ur Rahman, Yuri Vyatkin, Ani Azatyan, Georges St. Laurent, Philipp Kapranov, Peter G. Zaphiropoulos
Publikováno v: Molecular Oncology, Vol 12, Iss 10, Pp 1718-1734 (2018)
Hedgehog (HH) signaling is involved in many physiological processes, and pathway deregulation can result in a wide range of malignancies. Glioma‐associated oncogene 1 (GLI1) is a transcription factor and a terminal effector of the HH cascade. Despi
Externí odkaz: https://doaj.org/article/fd8f7677fd4f4dadae21d24e3b850489
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2
Circular and Fusion RNAs in Medulloblastoma Development
Autor: Ani Azatyan, Peter G. Zaphiropoulos
Publikováno v: Cancers; Volume 14; Issue 13; Pages: 3134
Background. The cerebellar cancer medulloblastoma is the most common childhood cancer in the brain. Methods. RNA sequencing of 81 human biospecimens of medulloblastoma using pipelines to detect circular and fusion RNAs. Validation via PCR and Sanger
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf8ac2efb1a144e151c8a60518200d2
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3
Blockade of the Hedgehog pathway downregulates estrogen receptor alpha signaling in breast cancer cells
Autor: Ani Azatyan, Chunyan Zhao, Peter G. Zaphiropoulos, Yumei Diao, Jian Zhu, Mohammed Ferdous-Ur Rahman, Karin Dahlman-Wright
Publikováno v: Oncotarget
// Yumei Diao 1 , Ani Azatyan 1 , Mohammed Ferdous-Ur Rahman 1 , Chunyan Zhao 1 , Jian Zhu 1 , Karin Dahlman-Wright 1 , Peter G. Zaphiropoulos 1 1 Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden Correspondence to: Pet
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cc57c833d99eb552cb5eefff090649
https://doi.org/10.18632/oncotarget.12259
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4
Akademický článek
Novel mechanism of action on Hedgehog signaling by a suppressor of fused carboxy terminal variant.
Autor: Ulrica Tostar, Csaba Finta, Mohammed Ferdous-Ur Rahman, Takashi Shimokawa, Peter G Zaphiropoulos
Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37761 (2012)
The Suppressor of Fused (SUFU) protein plays an essential role in the Hedgehog (HH) signaling pathway, by regulation of the GLI transcription factors. Two major isoforms of human SUFU are known, a full-length (SUFU-FL) and a carboxy-terminal truncate
Externí odkaz: https://doaj.org/article/ee450d94fb0d42eb9854702ee3d739c3
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5
Identification of novel GLI1 target genes and regulatory circuits in human cancer cells
Autor: Peter G. Zaphiropoulos, Philipp Kapranov, Georges St. Laurent, Ani Azatyan, Yumei Diao, Mohammed Ferdous-Ur Rahman, Yuri Vyatkin
Publikováno v: Molecular Oncology
Molecular Oncology, Vol 12, Iss 10, Pp 1718-1734 (2018)
Hedgehog (HH) signaling is involved in many physiological processes, and pathway deregulation can result in a wide range of malignancies. Glioma‐associated oncogene 1 (GLI1) is a transcription factor and a terminal effector of the HH cascade. Despi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7bb821c0c232290bdbb65ac73abc94
https://doi.org/10.1002/1878-0261.12366
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6
Circular RNAs in Hedgehog Signaling Activation and Hedgehog-Mediated Medulloblastoma Tumors
Autor: Peter G. Zaphiropoulos, Ting Wang, Anna Darabi, Peter Siesjö, Ani Azatyan, Shasha Zhang
Publikováno v: Cancers
Volume 13
Issue 20
Cancers, Vol 13, Iss 5138, p 5138 (2021)
Simple Summary Here the expression profile of circular RNAs in Hedgehog signaling-dependent cell lines and medulloblastoma cells was interrogated. Using stringent criteria, a reduced expression of seven circular RNAs in Hedgehog-dependent medulloblas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827fb89f9445a7c8f375378ffc4e339b
https://doi.org/10.3390/cancers13205138
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7
RITA downregulates Hedgehog-GLI in medulloblastoma and rhabdomyosarcoma via JNK-dependent but p53-independent mechanism
Autor: Galina Selivanova, Yumei Diao, Ani Azatyan, Peter G. Zaphiropoulos, Gabriel Gallo-Oller, John Inge Johnsen
Publikováno v: Cancer letters. 442
Overactivation of the Hedgehog (HH) signaling pathway is implicated in many cancers. In this study, we demonstrate that the small molecule RITA, a p53 activator, effectively downregulates HH signaling in human medulloblastoma and rhabdomyosarcoma cel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61fbd68ed7b6e174d2cf68f10826c699
https://pubmed.ncbi.nlm.nih.gov/30447254
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8
Neighboring Gene Regulation by Antisense Long Non-Coding RNAs
Autor: Peter G. Zaphiropoulos, Victoria E. Villegas
Publikováno v: International Journal of Molecular Sciences, Vol 16, Iss 2, Pp 3251-3266 (2015)
International Journal of Molecular Sciences
Antisense transcription, considered until recently as transcriptional noise, is a very common phenomenon in human and eukaryotic transcriptomes, operating in two ways based on whether the antisense RNA acts in cis or in trans. This process can genera
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536cc5370ca138e2b1abac11213c2173
http://www.mdpi.com/1422-0067/16/2/3251
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9
RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling
Autor: Peter G. Zaphiropoulos, Mona Ståhle, Enikö Sonkoly, Ulrica Tostar, Takashi Shimokawa, Ramesh Palaniswamy, Andor Pivarcsi, Mohammed Ferdous-Ur Rahman
Publikováno v: RNA Biology
The Hedgehog (HH) signaling pathway has important roles in tumorigenesis and in embryonal patterning. The Glioma-associated oncogene 1 (GLI1) is a key molecule in HH signaling, acting as a transcriptional effector and, moreover, is considered to be a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ce624dff8fd5269f96e824c6d2b4a9
https://repo.qst.go.jp/records/46769
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10
Tamoxifen treatment of breast cancer cells : Impact on Hedgehog/GLI1 signaling
Autor: Isabella Castellano, Anna Sapino, Victoria E. Villegas, Laura Annaratone, Adriana Grismaldo, Peter G. Zaphiropoulos, Milena Rondón-Lagos
Publikováno v: Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 17; Issue 3; Pages: 308
International Journal of Molecular Sciences, Vol 17, Iss 3, p 308 (2016)
The selective estrogen receptor (ER) modulator tamoxifen (TAM) has become the standard therapy for the treatment of ER+ breast cancer patients. Despite the obvious benefits of TAM, a proportion of patients acquire resistance to treatment, and this is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e69a05475edb93789411bf76cc5f84
https://repository.urosario.edu.co/handle/10336/21353
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