Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Peter G, Stockley"'
Autor:
David Gil-Cantero, Carlos P. Mata, Luis Valiente, Alicia Rodríguez-Huete, Alejandro Valbuena, Reidun Twarock, Peter G. Stockley, Mauricio G. Mateu, José R. Castón
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract The cryo-EM structure of the human rhinovirus B14 determined in this study reveals 13-bp RNA duplexes symmetrically bound to regions around each of the 30 two-fold axes in the icosahedral viral capsid. The RNA duplexes (~12% of the ssRNA gen
Externí odkaz:
https://doaj.org/article/947dff4d4c24426db0aa5d6dad9abe91
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Hepatitis B virus (HBV) is a global health threat, and its elimination by 2030 has been prioritised by the World Health Organisation. Here we present an age-structured model for the immune response to an HBV infection, which takes into accou
Externí odkaz:
https://doaj.org/article/cd2be38822204272abcd2df327bb8fd0
Autor:
Farzad Fatehi, Richard J. Bingham, Pierre-Philippe Dechant, Peter G. Stockley, Reidun Twarock
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Defective interfering particles arise spontaneously during a viral infection as mutants lacking essential parts of the viral genome. Their ability to replicate in the presence of the wild-type (WT) virus (at the expense of viable viral parti
Externí odkaz:
https://doaj.org/article/27b8dfca48d243b0ba89cabbcee5580e
Autor:
Nikesh Patel, Sam Clark, Eva U. Weiß, Carlos P. Mata, Jen Bohon, Erik R. Farquhar, Daniel P. Maskell, Neil A. Ranson, Reidun Twarock, Peter G. Stockley
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Patel et al. investigate the role of RNA sequence/structure motif ‘Packaging Signals’ (PSs) in regulating the assembly of an HBV genome transcript using an in vitro assay containing only core protein (Cp) and RNA. They show that RNA PSs regulate
Externí odkaz:
https://doaj.org/article/3b4af1bc4af64546b9b05eec2f92eb57
Autor:
Fardokht Abulwerdi, Farzad Fatehi, Iain W. Manfield, Stuart F.J. Le Grice, John S. Schneekloth, Reidun Twarock, Peter G. Stockley, Nikesh Patel
Publikováno v:
Data in Brief, Vol 42, Iss , Pp 108206- (2022)
Multiple ssRNA viruses which infect bacteria, plants or humans use RNA Packaging Signal (PS)-mediated regulation during assembly to package their genomes faithfully and efficiently. PSs typically comprise short nucleotide recognition motifs, most oft
Externí odkaz:
https://doaj.org/article/1f4a24cc33804de5b1e26862f06ae21e
Autor:
Peter G Stockley, Reidun Twarock
Emerging Topics in Physical Virology is a state-of-the-art account of recent advances in the experimental analysis and modeling of structure, function and dynamics of viruses. It is the first interdisciplinary book that integrates a review of relevan
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 324:G415-G418
Diarrhea, often severe, is a recognized and frequently early symptom during acute COVID-19 infection and may persist or develop for the first time in patients with long-COVID, with socioeconomic consequences. Diarrheal mechanisms in these cases are p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::411611dc78c82bfe2a8a491a45fb6f1e
https://doi.org/10.1152/ajpgi.00021.2023
https://doi.org/10.1152/ajpgi.00021.2023
Autor:
Rebecca Chandler-Bostock, Carlos P Mata, Richard J Bingham, Eric C Dykeman, Bo Meng, Tobias J Tuthill, David J Rowlands, Neil A Ranson, Reidun Twarock, Peter G Stockley
Publikováno v:
PLoS Pathogens, Vol 16, Iss 12, p e1009146 (2020)
Picornaviruses are important viral pathogens, but despite extensive study, the assembly process of their infectious virions is still incompletely understood, preventing the development of anti-viral strategies targeting this essential part of the lif
Externí odkaz:
https://doaj.org/article/e4d31b1bf4ee435ab3bd30a7c44a740a
Autor:
Shabih Shakeel, Eric C. Dykeman, Simon J. White, Ari Ora, Joseph J.B. Cockburn, Sarah J. Butcher, Peter G. Stockley, Reidun Twarock
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The mechanism underlying packaging of genomic RNA into viral particles is not well understood for human parechoviruses. Here the authors identify short RNA motifs in the parechovirus genome that bind capsid proteins, providing approximately 60 specif
Externí odkaz:
https://doaj.org/article/1edc545ea86c44ca9bf0cec5084edbad
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-3 (2018)
Externí odkaz:
https://doaj.org/article/fddedbb405b641e59ac280f1a5f630b6