Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Peter G, Alexander"'
Autor:
Tomoya Iseki, Benjamin B. Rothrauff, Shinsuke Kihara, Kalon J. Overholt, Tarek Taha, Hang Lin, Peter G. Alexander, Rocky S. Tuan
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Introduction Intra-articular injection of adipose-derived mesenchymal stromal cells (ASCs) and/or platelet-rich plasma (PRP) have been reported to independently and synergistically improve healing of osteochondral lesions in animal models. H
Externí odkaz:
https://doaj.org/article/0b80475a1bc744f9b12e1492c2799084
Autor:
Kathryn A. F. Pennel, Phimmada Hatthakarnkul, Colin S. Wood, Guang-Yu Lian, Sara S. F. Al-Badran, Jean A. Quinn, Assya Legrini, Jitwadee Inthagard, Peter G. Alexander, Hester van Wyk, Ahmad Kurniawan, Umar Hashmi, Michael A. Gillespie, Megan Mills, Aula Ammar, Jennifer Hay, Ditte Andersen, Colin Nixon, Selma Rebus, David K. Chang, Caroline Kelly, Andrea Harkin, Janet Graham, David Church, Ian Tomlinson, Mark Saunders, Tim Iveson, Tamsin R. M. Lannagan, Rene Jackstadt, Noori Maka, Paul G. Horgan, Campbell S. D. Roxburgh, Owen J. Sansom, Donald C. McMillan, Colin W. Steele, Nigel B. Jamieson, James H. Park, Antonia K. Roseweir, Joanne Edwards
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)
Abstract Colorectal cancer (CRC) is a heterogenous malignancy underpinned by dysregulation of cellular signaling pathways. Previous literature has implicated aberrant JAK/STAT3 signal transduction in the development and progression of solid tumors. I
Externí odkaz:
https://doaj.org/article/3b63169b435447a19a5fb490ee037279
Autor:
Chunrong He, Karen L. Clark, Jian Tan, Hecheng Zhou, Rocky S. Tuan, Hang Lin, Song Wu, Peter G. Alexander
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-13 (2022)
Abstract Background Traumatic impacts to the articular joint surface are known to lead to cartilage degeneration, as in post-traumatic osteoarthritis (PTOA). Limited progress in the development of disease-modifying OA drugs (DMOADs) may be due to ins
Externí odkaz:
https://doaj.org/article/88e061e33f8c47b1b7460fb3c3e97d71
Autor:
Brendan A McGrath, James Lynch, Peter G Alexander, Glen Cooper, Ruth Coleman, Clifford L Shelton, Angela Gardner
Publikováno v:
BMJ Open, Vol 13, Iss 5 (2023)
Objectives We aimed to design and produce a low-cost, ergonomic, hood-integrated powered air-purifying respirator (Bubble-PAPR) for pandemic healthcare use, offering optimal and equitable protection to all staff. We hypothesised that participants wou
Externí odkaz:
https://doaj.org/article/be7f3e29d63648bbb4255d62d8e1079b
Autor:
Guorui Cao, La Li, Shiqi Xiang, Hang Lin, Fuxing Pei, Rocky Sung Chi Tuan, Peter G. Alexander
Publikováno v:
Journal of Orthopaedic Surgery, Vol 31 (2023)
Background Muscle injury and concomitant bone injury are important drivers to induce heterotopic ossification (HO). However, the related roles of muscle and concomitant bone injury in HO formation are still unclear. This study aims to develop a mouse
Externí odkaz:
https://doaj.org/article/ca2cc155cd8f44d0acf26906c87a13a5
Autor:
Shiqi Xiang, Zixuan Lin, Meagan J. Makarcyzk, Kanyakorn Riewruja, Yiqian Zhang, Xiurui Zhang, Zhong Li, Karen L. Clark, Eileen Li, Silvia Liu, Tingjun Hao, Madalyn R. Fritch, Peter G. Alexander, Hang Lin
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 12, Pp n/a-n/a (2022)
Abstract Background Human multipotent progenitor cells (hiMPCs) created from induced pluripotent stem cells (iPSCs) represent a new cell source for cartilage regeneration. In most studies, bone morphogenetic proteins (BMPs) are needed to enhance tran
Externí odkaz:
https://doaj.org/article/e8827580f394402bbc112ead85bcb966
Autor:
Kanyakorn Riewruja, Meagan Makarczyk, Peter G. Alexander, Qi Gao, Stuart B. Goodman, Bruce A. Bunnell, Michael S. Gold, Hang Lin
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 4, Iss 4, Pp 100306- (2022)
Pain is the predominant symptom of osteoarthritis (OA) that drives patients to seek medical care. Currently, there are no pharmacological treatments that can reverse or halt the progression of OA. Safe and efficacious medications for long-term manage
Externí odkaz:
https://doaj.org/article/a057896c31fa4b57b947d316fe67844c
Autor:
Zhong Li, Zixuan Lin, Silvia Liu, Haruyo Yagi, Xiurui Zhang, Lauren Yocum, Monica Romero‐Lopez, Claire Rhee, Meagan J. Makarcyzk, Ilhan Yu, Eileen N. Li, Madalyn R. Fritch, Qi Gao, Kek Boon Goh, Benjamen O'Donnell, Tingjun Hao, Peter G. Alexander, Bhushan Mahadik, John P. Fisher, Stuart B. Goodman, Bruce A. Bunnell, Rocky S. Tuan, Hang Lin
Publikováno v:
Advanced Science, Vol 9, Iss 21, Pp n/a-n/a (2022)
Abstract Diseases of the knee joint such as osteoarthritis (OA) affect all joint elements. An in vitro human cell‐derived microphysiological system capable of simulating intraarticular tissue crosstalk is desirable for studying etiologies/pathogene
Externí odkaz:
https://doaj.org/article/74a01e20f19b40abb97cd5398781aced
Autor:
Haruyo Yagi, Antonia F. Chen, David Hirsch, Adam C. Rothenberg, Jian Tan, Peter G. Alexander, Rocky S. Tuan
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-12 (2020)
Abstract Introduction There have been limited advances in the treatment of bone and joint infections, which currently involves a combination of surgery and antibiotic administration. There is a timely need in orthopedics to develop more effective and
Externí odkaz:
https://doaj.org/article/2db7c79322d14e198fcaf47885e22ce3
Autor:
Xueqi Wang, Yiming Guan, Shiyu Xiang, Karen L. Clark, Peter G. Alexander, Lauren E. Simonian, Yuhao Deng, Hang Lin
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
In the past 3 decades, the cartilage repair potential of mesenchymal stromal cells, or mesenchymal stem cells (MSCs), has been widely examined in animal studies. Unfortunately, the phenotype and physical properties of MSC-derived cartilage tissue are
Externí odkaz:
https://doaj.org/article/51e762edf08944608ee274ed9f238b3a