Výsledky vyhledávání - "Peter Franz Ertl"

Rapid identification of highly potent human anti-GPCR antagonist monoclonal antibodies

Autor: Martin J. Scott, David Gower, Michael L Washburn, Katie Poulton, Alan Peter Lewis, Larissa Ouro-Gnao, Ruud de Wildt, Martin Anibal Orecchia, John Yates, Nick Barton, Carol A. Harris, Kathrine J. Smith, Julia Ticehurst, Michael J. Mullin, Peter Franz Ertl, Amanda Jowett

Publikováno v: mAbs

Complex cellular targets such as G protein-coupled receptors (GPCRs), ion channels, and other multi-transmembrane proteins represent a significant challenge for therapeutic antibody discovery, primarily because of poor stability of the target protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f40392ac54a6d941aeaab92117d5f5
http://europepmc.org/articles/PMC7188403

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Immune-response profiles induced by human immunodeficiency virus type 1 vaccine DNA, protein or mixed-modality immunization: increased protection from pathogenic simian–human immunodeficiency virus viraemia with protein/DNA combination

Autor: Gerrit Koopman, Sam O. Hofman, Nathalie Louise Mathy, Jonathan L. Heeney, Peter Franz Ertl, Marguerite Koutsoukos, Daniella Mortier, Cathy van Wely, Phil Overend, Gerald Voss, Lindy L. Thomsen, Britta Wahren

Publikováno v: Journal of General Virology. 89:540-5533

Current data suggest that prophylactic human immunodeficiency virus type 1 (HIV) vaccines will be most efficacious if they elicit a combination of adaptive humoral and T-cell responses. Here, we explored the use of different vaccine strategies in het

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d14cd75ceb758191322893070b7ef43d
https://doi.org/10.1099/vir.0.83384-0

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Evaluation of immunogenicity and efficacy of combined DNA and adjuvanted protein vaccination in a human immunodeficiency virus type 1/murine leukemia virus pseudotype challenge model

Autor: Andreas Boberg, Andreas Bråve, Erik Rollman, Anne Kjerrström, Kajsa Aperia, Reinhold Benthin, Gunnel Engström, Susanne Johansson, Nathalie Louise Mathy, Jorma Hinkula, Jonathan L. Heeney, Cathy van Wely, Peter Franz Ertl, Lars E. Eriksson, Britta Wahren, Gerald Voss

Publikováno v: Vaccine. 25:2145-2154

A DNA plasmid encoding human immunodeficiency virus type 1 (HIV-1) env, nef and tat genes was used in mice in a prime-boost immunization regimen with the corresponding recombinant proteins. The genetic immunogen was delivered with a gene gun and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c2beb314ae28efe49884a21f239981
https://doi.org/10.1016/j.vaccine.2006.10.057

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Technical issues in construction of nucleic acid vaccines

Autor: Lindy L. Thomsen, Peter Franz Ertl

Publikováno v: Methods. 31:199-206

Delivery of antigen-encoding genes by nucleic acid vaccine vectors offers tremendous advantages in power and flexibility over conventional antigen delivery systems. Of the many forms of nucleic acid vaccine that can be constructed, circular DNA plasm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f2414b18485188f77226478981524a9
https://doi.org/10.1016/s1046-2023(03)00134-8

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Design and Synthesis of Pyrrolidine-5,5‘-trans-Lactams (5-Oxo-hexahydropyrrolo[3,2-b]pyrroles) as Novel Mechanism-Based Inhibitors of Human Cytomegalovirus Protease. 4. Antiviral Activity and Plasma Stability

Autor: Deborah L. Jackson, Graham J Hart, Angela Patikis, Gordon G. Weingarten, Nigel R. Parry, Alan D. Borthwick, James Michael Woolven, Terry M. Haley, Dave E. Davies, Anne M. Exall, Peter Franz Ertl, Naimisha Trivedi

Publikováno v: Journal of Medicinal Chemistry. 46:4428-4449

A series of chiral, (S)-proline-alpha-methylpyrrolidine-5,5-trans-lactam serine protease inhibitors has been developed as antivirals of human cytomegalovirus (HCMV). The SAR of the functionality on the proline nitrogen has shown that derivatives of p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2b6a73dae4a667f9c1ac9169b95e88
https://doi.org/10.1021/jm030810w

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Therapeutic DNA Vaccine Induces Broad T Cell Responses in the Gut and Sustained Protection from Viral Rebound and AIDS in SIV-Infected Rhesus Macaques

Autor: Tite John Philip, Julia Nyaundi, Michael Murphey-Corb, Heather Michael, Eric J. Yager, Peter Franz Ertl, Cristy Stagnar, Jenny W. Che, Angela M. Amedee, Premeela A. Rajakumar, Rachel Taber, Amithi Narendran, Fiona C. Cook, Brendon Wahlberg, Deborah H. Fuller, Joel R. Haynes

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 3, p e33715 (2012)

Immunotherapies that induce durable immune control of chronic HIV infection may eliminate the need for life-long dependence on drugs. We investigated a DNA vaccine formulated with a novel genetic adjuvant that stimulates immune responses in the blood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce04f4b06df60e723e10b3e86e590f3
http://europepmc.org/articles/PMC3307760

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High-frequency interferon-gamma-secreting splenocytes specific for murine cytomegalovirus immediate-early-1 (IE-1) peptide 168YPHFMPTNL176 are insufficient to provide complete protection from viral challenge

Autor: Peter J. Morley, Peter Franz Ertl, Clive Sweet

Publikováno v: Journal of medical virology. 69(2)

Infection of Balb/c mice with murine cytomegalovirus (MCMV) has been used extensively as a model system with which to study host mechanisms of immunity to cytomegaloviruses. In this model, the cytotoxic T-lymphocyte (CTL) response crucial for clearin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c56285c82382969830b199f595c682c
https://pubmed.ncbi.nlm.nih.gov/12683414

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Immunisation of Balb/c mice with severely attenuated murine cytomegalovirus mutants induces protective cellular and humoral immunity

Autor: Peter J. Morley, Peter Franz Ertl, Clive Sweet

Publikováno v: Journal of medical virology. 67(2)

Previously, we showed that two temperature-sensitive mutants of murine cytomegalovirus (tsm5 and tsm30) expressed immediate-early (IE-1), early (E-1), and late (gB) phase genes in the tissues of immunocompetent Balb/c mice, yet failed to produce infe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::695f90dc8cd267b1998f0ed97595c5e9
https://pubmed.ncbi.nlm.nih.gov/11992579

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Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxohexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 2. Potency and chirality

Autor: Anne M. Exall, Graham J Hart, Onkar M. P. Singh, Peter Franz Ertl, James Michael Woolven, Andrew J Crame, Alan D. Borthwick, Terry M. Haley, Gordon G. Weingarten, Andrew M. Mason, Andrew M K Pennell

Publikováno v: Journal of medicinal chemistry. 45(1)

The stereospecific synthesis of a series of alpha-methylpyrrolidine-5,5-trans-lactam inhibitors of human cytomegalovirus (HCMV) protease is described. Examination of the SAR in this series has defined the size and chirality of the alpha-substituent,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e67785bd8f7796230ecc7de3973c492
https://pubmed.ncbi.nlm.nih.gov/11754575

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