TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells

Autor: Jerzy A. Woznicki, Nisha Saini, Peter Flood, Subhasree Rajaram, Ciaran M. Lee, Panagiota Stamou, Agnieszka Skowyra, Milan Bustamante-Garrido, Karine Regazzoni, Nyree Crawford, Simon S. McDade, Daniel B. Longley, Pedro Aza-Blanc, Fergus Shanahan, Syed A. Zulquernain, Jane McCarthy, Silvia Melgar, Bradford L. McRae, Ken Nally

Publikováno v: Cell Death and Disease, Vol 12, Iss 10, Pp 1-15 (2021)

Abstract Rewiring of host cytokine networks is a key feature of inflammatory bowel diseases (IBD) such as Crohn’s disease (CD). Th1-type cytokines—IFN-γ and TNF-α—occupy critical nodes within these networks and both are associated with disrup

Externí odkaz: https://doaj.org/article/3fd851ad37fa451687518ec09ff3247a

Fragmentation alters ecological gradients and headwater fish assemblage composition relative to land use in a dendritic river system

Autor: Melvin L. Warren, Peter Flood, Jake F. Schaefer, Kenneth A. Sterling, Joshua P. Hubbell

Publikováno v: Canadian Journal of Fisheries and Aquatic Sciences. 77:1281-1291

The spatial and hydrological properties of headwaters allow dendritic systems to contribute to patterns of regional diversity. However, such ecological gradients may be disrupted as a result of habitat fragmentation. We tested the hypothesis that coa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3d703bfa7f53f5629d4a5a57e1290a2
https://doi.org/10.1139/cjfas-2019-0080

TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells

Autor: Subhasree Rajaram, Simon S. McDade, Daniel B. Longley, Panagiota Stamou, Pedro Aza-Blanc, Ciaran M. Lee, Jerzy A. Woznicki, Karine Regazzoni, Nisha Saini, Nyree Crawford, Kenneth Nally, Fergus Shanahan, Jane McCarthy, Agnieszka Skowyra, Syed Akbar Zulquernain, Milan Bustamante-Garrido, Bradford L McRae, Silvia Melgar, Peter Flood

Publikováno v: Woznicki, J A, Saini, N, Flood, P, Rajaram, S, Lee, C M, Stamou, P, Skowyra, A, Bustamante-Garrido, M, Regazzoni, K, Crawford, N, McDade, S S, Longley, D B, Aza-Blanc, P, Shanahan, F, Zulquernain, S A, McCarthy, J, Melgar, S, McRae, B L & Nally, K 2021, ' TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells ', Cell, Death & Disease, vol. 12, 864 . https://doi.org/10.1038/s41419-021-04151-3
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 10, Pp 1-15 (2021)

Rewiring of host cytokine networks is a key feature of inflammatory bowel diseases (IBD) such as Crohn’s disease (CD). Th1-type cytokines—IFN-γ and TNF-α—occupy critical nodes within these networks and both are associated with disruption of g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::924890d99a776d6334e0fc589b423a46
https://pure.qub.ac.uk/en/publications/14c63377-1829-45d8-812f-a5990eae4915

Sport and the Media: Recent Economic, Legal, and Technological Developments

Autor: Deirdre Kevin, Peter Flood, Raymond Boyle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00b72a318d318bbbcda62e9e70b4cf08
https://doi.org/10.4324/9781315046013

A 3-D cell culture system to study epithelia functions using microcarriers

Autor: Petra Jakob, Ernst H. K. Stelzer, Peter Flood, Markus Meissner, Jessica Kehrer, Emmanuel G. Reynaud, Uta Haselmann, Catharina Wiegel

Publikováno v: Cytotechnology. 68:1813-1825

In vitro cell culture models used to study epithelia and epithelial diseases would benefit from the recognition that organs and tissues function in a three-dimensional (3D) environment. This context is necessary for the development of cultures that m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974670f3c3941963a79f09389306fe86
https://doi.org/10.1007/s10616-015-9935-0