Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Peter Flecker"'
Publikováno v:
Journal of Molecular Biology. 298:477-491
Understanding molecular recognition on a structural basis is an objective with broad academic and applied significance. In the complexes of serine proteases and their proteinaceous inhibitors, recognition is governed mainly by residue P1 in accord wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127e8c329d5b1546f15f8101f1bf5bb4
https://doi.org/10.1006/jmbi.2000.3677
https://doi.org/10.1006/jmbi.2000.3677
Publikováno v:
Journal of Biochemical and Biophysical Methods. 33:171-185
The hydrolysis of the soybean Bowman-Birk inhibitor in the presence of catalytic amounts of bovine trypsin and the formation of the non-covalent enzyme-inhibitor complex with an equimolar amount of enzyme are monitored by means of high-performance ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c71ec4db3d699d215e1339585f5567
https://doi.org/10.1016/s0165-022x(96)00024-3
https://doi.org/10.1016/s0165-022x(96)00024-3
Autor:
Peter Flecker
Publikováno v:
European Journal of Biochemistry. 232:528-535
The principal objective of this work was to distinguish between kinetic and thermodynamic reaction control in protein folding. The deleterious effects of a specific mutation on spontaneous refolding competence were analyzed for this purpose. A Bowman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129f07d87eaf308390b751989e04d911
https://doi.org/10.1111/j.1432-1033.1995.528zz.x
https://doi.org/10.1111/j.1432-1033.1995.528zz.x
Publikováno v:
Liebigs Annalen der Chemie. 1990:857-862
Stereoselective Synthesis of rac-Yohimb-15-enone The Robinson annulation of an octahydroindolo[2,3-α]quinolizin-2-one is a general concept for the synthesis of yohimbine alkaloids. Using the phenylsulfonyl group for activation, a diastereoselective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2606da08cb39cbe7c020c1ae3c2ef4c8
https://doi.org/10.1002/jlac.1990199001161
https://doi.org/10.1002/jlac.1990199001161
Publikováno v:
European journal of biochemistry. 251(3)
It is widely believed that protein folding is a hierarchical process proceeding from secondary structure via subdomains and domains towards the complete tertiary structure. Accordingly, protein subdomains should behave as independent folding units. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2305644b6c620f9dff21eda1bf4e8e3
https://pubmed.ncbi.nlm.nih.gov/9490061
https://pubmed.ncbi.nlm.nih.gov/9490061
Autor:
Peter Flecker, Ralf-Holger Voss, Gabriele Wenzl, Ulrich Ermler, Lars-Oliver Essen, Young-Mi Kim
Publikováno v:
European journal of biochemistry. 242(1)
The Bowman-Birk inhibitor from soybean is a small protein that contains a binary arrangement of trypsin-reactive and chymotrypsin-reactive subdomains. In this report, the crystal structure of this anticarcinogenic protein has been determined to 0.28-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032dc85170010ccccb4c7835b67058c0
https://pubmed.ncbi.nlm.nih.gov/8954162
https://pubmed.ncbi.nlm.nih.gov/8954162
Autor:
Peter Flecker
Publikováno v:
Protease Inhibitors as Cancer Chemopreventive Agents ISBN: 9781461362494
Proteinase inhibitors are a class of the various dietary inhibitors of mutagenesis and carcinogenesis (Hayatsu et al., 1988). Schelp and Pongpaew (1988) have recently hypothesized that protection against cancer may result from an increase of endogeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f63a4910c7a330d0b77bc7d880c17104
https://doi.org/10.1007/978-1-4615-2882-1_9
https://doi.org/10.1007/978-1-4615-2882-1_9
Autor:
Peter Flecker
Publikováno v:
Modern Methods in Protein-and Nucleic Acid Research
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab8743601e1df941cd81005738ba25f9
https://doi.org/10.1515/9783110853537-010
https://doi.org/10.1515/9783110853537-010
Autor:
Peter Flecker
Publikováno v:
FEBS Letters. 252:153-157
The trypsin-reactive subdomain of the Bowman-Birk-inhibitor of serine proteinases is shown to be highly vulnerable to perturbations induced by single amino acid replacements. Dramatic deviations from a stoichiometric 1:1 ratio to the chymotrypsin-rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de56b34b8883e9134b68395f378b7e81
https://doi.org/10.1016/0014-5793(89)80909-3
https://doi.org/10.1016/0014-5793(89)80909-3
Autor:
Ekkehard Winterfeldt, Peter flecker
Publikováno v:
Tetrahedron. 40:4853-4863
The condensation products of secoaldehydes 4 and 16 with N-benzyl-tryptophane-methylester can be easily transformed into pentacyclic indole-alkaloid analogues.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b4d837e2f4be6a0a1656cb0fb41a92f
https://doi.org/10.1016/s0040-4020(01)91319-5
https://doi.org/10.1016/s0040-4020(01)91319-5