Voriconazole or amphotericin B as primary therapy yields distinct early serum galactomannan trends related to outcomes in invasive aspergillosis.

Autor: Louis Yi Ann Chai, Bart Jan Kullberg, Arul Earnest, Elizabeth M Johnson, Steven Teerenstra, Alieke G Vonk, Haran T Schlamm, Raoul Herbrecht, Mihai G Netea, Peter F Troke

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e90176 (2014)

An improved number of anti-fungal drugs are currently available for the treatment of invasive aspergillosis (IA). While serial galactomannan index (GMI) measurement can be used to monitor response to treatment, the extent to which different anti-fung

Externí odkaz: https://doaj.org/article/94a18cd2e90f47fcba4073381a50a40e

Neutrophils differentially attenuate immune response to Aspergillus infection through complement receptor 3 and induction of myeloperoxidase

Autor: Mihai G. Netea, Yock Young Dan, Winnie Leong, Raoul Herbrecht, Bart Jan Kullberg, Wee Joo Chng, Louis Yi Ann Chai, Sharada Ravikumar, Joan H. J. Lim, Jessamine Geraldine Goh, Mar Soe Win, Ai Ling Tan, Qiong Cao, Peter F. Troke

Publikováno v: Cellular Microbiology, 20,
Cellular Microbiology, 20, 3, pp.

Invasive aspergillosis (IA) remains a major cause of morbidity in immunocompromised hosts. This is due to the inability of the host immunity to respond appropriately to Aspergillus. An established risk factor for IA is neutropenia that is encountered

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b223f3f3cfa0fb949dcb841a9d2a549
https://hdl.handle.net/2066/183971

An elevated pro-inflammatory cytokine response is linked to development of amphotericin B-induced nephrotoxicity

Autor: Boon Wee Teo, Lay Wai Khin, Bart Jan Kullberg, Bee Choo Tai, Louis Y.A. Chai, Alieke G. Vonk, Raoul Herbrecht, Peter F. Troke, J.P. Donnelly, Haran T. Schlamm, Mihai G. Netea

Publikováno v: Journal of Antimicrobial Chemotherapy, 68, 7, pp. 1655-9
Journal of Antimicrobial Chemotherapy, 68(7), 1655-1659. Oxford University Press
Journal of Antimicrobial Chemotherapy, 68, 1655-9

Item does not contain fulltext OBJECTIVES: The underlying mechanism for amphotericin B-induced acute kidney injury (AKI) remains poorly understood and may be immunologically mediated. We assessed whether the development of nephrotoxicity is linked to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7c72d69e14090e4ce850ffffb4959e
https://pure.eur.nl/en/publications/47067dc5-a9a8-4570-9472-858f906326c1

Observational Study of the Clinical Efficacy of Voriconazole and Its Relationship to Plasma Concentrations in Patients

Autor: William W. Hope, Hans Hockey, Peter F. Troke

Publikováno v: Antimicrobial Agents and Chemotherapy. 55:4782-4788

Voriconazole is approved for treating invasive fungal infections. We examined voriconazole exposure-response relationships for patients from nine published clinical trials. The relationship between the mean voriconazole plasma concentration ( C avg )

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61e735924715e1965deb4acc41313a2
https://doi.org/10.1128/aac.01083-10

Activity of voriconazole, itraconazole, fluconazole and amphotericin B in vitro against 1763 yeasts from 472 patients in the voriconazole phase III clinical studies

Autor: Adrien Szekely, Elizabeth M. Johnson, Hans Hockey, Peter F. Troke, Ana Espinel-Ingroff

Publikováno v: International Journal of Antimicrobial Agents. 32:511-514

The susceptibility of 1763 yeast isolates (from 22 species and seven genera) was tested using Clinical and Laboratory Standards Institute M27-A2 microdilution methodology. Candida spp. predominated (97.1%), mainly C. albicans (51.4%), C. glabrata (16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506ddfac867a865b501b50e0924bb128
https://doi.org/10.1016/j.ijantimicag.2008.05.023