Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Peter F. Thadeio"'
Autor:
Mark R. Cullen, Adina R. Lemeshow, Sandra Amaro, Elisa V. Bandera, Lisa A. Cooper, Ichiro Kawachi, Joseph Lunyera, Laura McKinley, Christopher S. Poss, Melinda M. Rottas, Stephen E. Schachterle, Peter F. Thadeio, Leo J. Russo
Publikováno v:
Contemporary Clinical Trials. 129:107184
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c9f1610c995c03f210c511e93f5e6a0
https://doi.org/10.1016/j.cct.2023.107184
https://doi.org/10.1016/j.cct.2023.107184
Autor:
Raven Houck, David Gruben, David Scholfield, Peter F. Thadeio, Kannan Natarajan, Patrick J. McCann, Rob Goodwin, Brian Corrigan, Rod MacKenzie, Annette Schettino, Marie-Pierre Hellio, Melinda D. Rottas, Judy Sewards, Peter Honig, David Keller, Koshika Soma, Rachel Simons
Publikováno v:
Contemporary clinical trials. 106
The approval of new medicinal agents requires robust efficacy and safety clinical trial data demonstrated to be applicable to population subgroups. Limited data have previously been reported by drug sponsors on the topic of clinical trial diversity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f50ea7a2c3ff6cb4b50865d574bf573d
https://pubmed.ncbi.nlm.nih.gov/33940253
https://pubmed.ncbi.nlm.nih.gov/33940253
Publikováno v:
Nature Chemical Biology. 1:389-397
The high failure rate of experimental medicines in clinical trials accentuates inefficiencies of current drug discovery processes caused by a lack of tools for translating the information exchange between protein and organ system networks. Recently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed79dedfc381c1dd7b70678df65f15f
https://doi.org/10.1038/nchembio747
https://doi.org/10.1038/nchembio747
Publikováno v:
Proceedings of the National Academy of Sciences. 102:261-266
Establishing quantitative relationships between molecular structure and broad biological effects has been a longstanding challenge in science. Currently, no method exists for forecasting broad biological activity profiles of medicinal agents even wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7629fdf868f1284605caabab185fcf1
https://doi.org/10.1073/pnas.0407790101
https://doi.org/10.1073/pnas.0407790101
Autor:
Nicholas A. Saccomano, W S Faraci, Peter F. Thadeio, Steven D. Heck, Robert A. Volkmann, P R Kelbaugh
Publikováno v:
Proceedings of the National Academy of Sciences. 93:4036-4039
Since ribosomally mediated protein biosynthesis is confined to the L-amino acid pool, the presence of D-amino acids in peptides was considered for many years to be restricted to proteins of prokaryotic origin. Unicellular microorganisms have been res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5058f173d442cc268f14f6995bc6726c
https://doi.org/10.1073/pnas.93.9.4036
https://doi.org/10.1073/pnas.93.9.4036
Autor:
Justin G. Stroh, Nicholas A. Saccomano, Paul R. Kelbaugh, Heck Steven D, Robert A. Volkmann, Kelly Mary E, Peter F. Thadeio
Publikováno v:
Journal of the American Chemical Society. 116:10426-10436
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4a3db182052d95eba36b535997b9567
https://doi.org/10.1021/ja00102a009
https://doi.org/10.1021/ja00102a009
Publikováno v:
Tetrahedron Letters. 34:5831-5834
The synthesis of racemic CP-99,994, a highly potent substance P antagonist is reported. The synthesis outlined here is suitable for developing structure activity relationships for this important class of compounds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db4e77939bdd14fd92b83bb9054aff1b
https://doi.org/10.1016/s0040-4039(00)73791-9
https://doi.org/10.1016/s0040-4039(00)73791-9
Autor:
Lorraine A. Lebel, Morgan Meltz, Fredric J. Vinick, Stanley Jung, Nicholas A. Saccomano, Ian H. Williams, Lorena L. Russo, D. Helweg, J. A. Nielsen, B. K. Koe, J. L. Jun. Johnson, Peter F. Thadeio
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9274d951b0554ec22df69a959559019e
https://doi.org/10.1002/chin.199122155
https://doi.org/10.1002/chin.199122155
Autor:
Robin W. Spencer, Ian H. Williams, Christopher A. Lipinski, Manoj C. Desai, Dane R. Liston, Peter F. Thadeio
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 1:411-414
Two positions on the acetylcholinesterase (AChE) inhibitor, 9-amino-1,2,3,4-tetrahydroacridine (THA), have been identified which can be modified to vary log P, log D and pKa values. Most importantly, these changes can be carried out without altering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dfddf712b7170937f109379adbac4c6
https://doi.org/10.1016/s0960-894x(00)80267-x
https://doi.org/10.1016/s0960-894x(00)80267-x
Autor:
Robert D. Williams, Robert A. Volkmann, Thomas N. Parks, Kelly Mary E, Nicholas A. Saccomano, Chester J. Siok, Steven D. Heck, William R. Gray, Peter F. Thadeio, Karen J. Krapcho, Hunter Jackson, Michael K. Ahlijanian, Alan H. Ganong, Melissa J. Welch, Paul R. Kelbaugh, Anthony J. Lanzetti, Phillips Douglas
Publikováno v:
Science (New York, N.Y.). 266(5187)
The venom of the funnel-web spider Agelenopsis aperta contains several peptides that paralyze prey by blocking voltage-sensitive calcium channels. Two peptides, omega-Aga-IVB (IVB) and omega-Aga-IVC (IVC), have identical amino acid sequences, yet hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b741be6854425a53a7d12c897ab8d2
https://pubmed.ncbi.nlm.nih.gov/7973683
https://pubmed.ncbi.nlm.nih.gov/7973683