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Autor:
Peter F. Hall
Publikováno v:
Comprehensive Physiology
The sections in this article are: 1 Response to Stress 2 Diurnal Rhythm 3 Biosynthetic Pathway: Cholesterol Cortisol 3.1 Cytochromes P450 4 Action of Corticotropin on Synthesis of Cortisol 4.1 The Corticotropin Receptor 4.2 Second Messengers 5 Locus
Autor:
Peter F. Hall
Publikováno v:
Comprehensive Physiology
The sections in this article are: 1 Properties of Cytochromes P-450 1.1 Chemical Properties 1.2 Spectral Properties 1.3 The P-450 Cycle 1.4 The Mechanism of P-450 Enzyme Activity 1.5 Reduction of Cytochrome P-450 2 Synthesis of Steroid Hormones 2.1 N
Autor:
Ghanim Almahbobi, Peter F. Hall
Publikováno v:
Microscopy Research and Technique. 36:463-479
The problem for the steroidogenic cell if it is to accelerate steroid synthesis in response to trophic stimulation, consists in moving cholesterol from the sites of synthesis and storage to mitochondria at an accelerated rate. The most intensely stud
Autor:
Peter F. Hall
Publikováno v:
Steroids. 62:185-189
The rate of steroid synthesis is regulated by the rate of transport of cholesterol to mitochondria. The transport process involves two elements of the cytoskeleton (microfilaments and intermediate filaments) and Ca2+/ calmodulin. Electron microscopy
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1307:73-82
Regulation of CYP17 gene expression in porcine Leydig cells was investigated in primary culture. We previously reported the sequence of the 5′ upstream and much of the pig gene (Zhang et al. (1992) Biochim. Biophys. Acta. 1131. 345–348). DNase I
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1248:159-169
We have identified two GTP-binding proteins in mitochondria from bovine adrenal cortex (fasciculata). Sub-mitochondrial particles were fractionated into inner membrane, contact point and outer membrane vesicles on sucrose density gradients. These sub
Autor:
Peter F. Hall
Publikováno v:
Molecular Neurobiology. 10:1-17
Endozepine has recently been isolated from various steroid-forming organs. The following article explores the role of endozepine in the regulation of steroid synthesis. Steroid hormone synthesis from cholesterol begins in the inner mitochondrial memb
Autor:
Peter F. Hall, Ghanim Almahbobi
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 43(8)
The slow step in steroid synthesis involves the transport of cholesterol from lipid droplets in the cytoplasm to the first enzyme in the pathway-the cytochrome P450 that converts cholesterol to pregnenolone (P450scc) which is located in the inner mit
Publikováno v:
American Journal of Hypertension. 5:800-805
We have examined the regulation of cytochrome P-450 side chain cleavage enzyme (P-450SCC) and P-45011 beta (18) hydroxylase (P-450(11) beta) enzyme expression by angiotensin II (AII), the major regulator of aldosterone biosynthesis, in cultured human
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1171:73-80
The upstream region of the rat CYP17 gene shows significant homology to the upstream regions of the bovine and human genes, 53 and 60 percent, respectively. The start site of transcription was determined by primer extension and S1 nuclease protection