Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Peter F. Arndt"'
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109386- (2024)
Summary: During cellular processes such as differentiation or response to external stimuli, cells exhibit dynamic changes in their gene expression profiles. Single-cell RNA sequencing (scRNA-seq) can be used to investigate these dynamic changes. To t
Externí odkaz:
https://doaj.org/article/f6af53ccc8ad444f84ab5de7b73225c6
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-16 (2021)
Abstract Background Segmental duplications (SDs) are long DNA sequences that are repeated in a genome and have high sequence identity. In contrast to repetitive elements they are often unique and only sometimes have multiple copies in a genome. There
Externí odkaz:
https://doaj.org/article/04bf96620d0348878d135a5128951c71
Autor:
Michael Sheinman, Ksenia Arkhipova, Peter F Arndt, Bas E Dutilh, Rutger Hermsen, Florian Massip
Publikováno v:
eLife, Vol 10 (2021)
Horizontal gene transfer (HGT) is an essential force in microbial evolution. Despite detailed studies on a variety of systems, a global picture of HGT in the microbial world is still missing. Here, we exploit that HGT creates long identical DNA seque
Externí odkaz:
https://doaj.org/article/25de97cfdc684d93a6ff6815a0ec17b3
Autor:
Daniel Rosebrock, Sneha Arora, Naresh Mutukula, Rotem Volkman, Elzbieta Gralinska, Anastasios Balaskas, Amèlia Aragonés Hernández, René Buschow, Björn Brändl, Franz-Josef Müller, Peter F. Arndt, Martin Vingron, Yechiel Elkabetz
Publikováno v:
Nature Cell Biology
Cerebral organoids exhibit broad regional heterogeneity accompanied by limited cortical cellular diversity despite the tremendous upsurge in derivation methods, suggesting inadequate patterning of early neural stem cells (NSCs). Here we show that a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89126c57bc71ef7624a49f9f7ffe132f
https://doi.org/10.1038/s41556-022-00929-5
https://doi.org/10.1038/s41556-022-00929-5
Segmental duplications (SDs) are long genomic duplications fixed in a genome. SDs play an important evolutionary role: entire genes together with regulatory sequences can be duplicated. Ancestral segmental duplications gave rise to genes involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b358eee24a10a1c4c525b81a83540af
https://doi.org/10.1101/2023.03.18.533287
https://doi.org/10.1101/2023.03.18.533287
Publikováno v:
PLoS Genetics, Vol 14, Iss 3, p e1007254 (2018)
It has long been suspected that the rate of mutation varies across the human genome at a large scale based on the divergence between humans and other species. However, it is now possible to directly investigate this question using the large number of
Externí odkaz:
https://doaj.org/article/ce2adad0c48c4e5e9f69a143bd693296
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120206 (2015)
A Yule tree is the result of a branching process with constant birth and death rates. Such a process serves as an instructive null model of many empirical systems, for instance, the evolution of species leading to a phylogenetic tree. However, often
Externí odkaz:
https://doaj.org/article/5df732db76584192a1815512c0f1f0eb
Publikováno v:
BMC Genomics
BMC Genomics, Vol 22, Iss 1, Pp 1-16 (2021)
BMC Genomics, Vol 22, Iss 1, Pp 1-16 (2021)
BackgroundSegmental duplications (SDs) are long DNA sequences that are repeated in a genome and have high sequence identity. In contrast to repetitive elements they are often unique and only sometimes have multiple copies in a genome. There are sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7559d0910279fd4c70697c03070b4f65
https://doi.org/10.1186/s12864-021-07789-7
https://doi.org/10.1186/s12864-021-07789-7
Autor:
Ksenia Arkhipova, Peter F. Arndt, Rutger Hermsen, Florian Massip, Bas E. Dutilh, Michael Sheinman
Horizontal transfer of genomic elements is an essential force that shapes microbial genome evolution. Horizontal Gene Transfer (HGT) occurs via various mechanisms and has been studied in detail for a variety of systems. However, a coarse-grained, glo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2d3c25825fc80c50182767b7a140817
https://doi.org/10.1101/2020.06.09.139501
https://doi.org/10.1101/2020.06.09.139501
Publikováno v:
PLoS Genetics, Vol 7, Iss 10, p e1002276 (2011)
Nonsense Mediated Decay (NMD) degrades transcripts that contain a premature STOP codon resulting from mistranscription or missplicing. However NMD's surveillance of gene expression varies in efficiency both among and within human genes. Previous work
Externí odkaz:
https://doaj.org/article/fc8186032ae14e66aeecc45d891cd4a7