Zobrazeno 1 - 10
of 866
pro vyhledávání: '"Peter F Zipfel"'
Autor:
Stefan N Lang, Sebastian Germerodt, Christina Glock, Christine Skerka, Peter F Zipfel, Stefan Schuster
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212187 (2019)
Molecular mimicry is the formation of specific molecules by microbial pathogens to avoid recognition and attack by the immune system of the host. Several pathogenic Ascomycota and Zygomycota show such a behaviour by utilizing human complement factor
Externí odkaz:
https://doaj.org/article/5db0848bd2b946c0bc5670adc6ef6a2c
Autor:
Luciana M Pujol-Lereis, Gerhard Liebisch, Tina Schick, Yuchen Lin, Felix Grassmann, Koji Uchida, Peter F Zipfel, Sascha Fauser, Christine Skerka, Bernhard H F Weber
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0200739 (2018)
Sphingolipids are bioactive molecules associated with oxidative stress, inflammation, and neurodegenerative diseases, but poorly studied in the context of age-related macular degeneration (AMD), a prevalent sight-threatening disease of the ageing ret
Externí odkaz:
https://doaj.org/article/a28ed69574d14ec3a2b0ea7cf25d44a7
Autor:
Teresia Hallström, Birendra Singh, Peter Kraiczy, Sven Hammerschmidt, Christine Skerka, Peter F Zipfel, Kristian Riesbeck
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147709 (2016)
Pathogenicity of many microbes relies on their capacity to resist innate immunity, and to survive and persist in an immunocompetent human host microbes have developed highly efficient and sophisticated complement evasion strategies. Here we show that
Externí odkaz:
https://doaj.org/article/1d7ac08e1a2342b4bc303f5e9d04e225
Autor:
Teresia Hallström, Melanie Uhde, Birendra Singh, Christine Skerka, Kristian Riesbeck, Peter F Zipfel
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137630 (2015)
The opportunistic human pathogen Pseudomonas aeruginosa controls host innate immune and complement attack. Here we identify Dihydrolipoamide dehydrogenase (Lpd), a 57 kDa moonlighting protein, as the first P. aeruginosa protein that binds the two hum
Externí odkaz:
https://doaj.org/article/d8a70d74131f4bddac8ed3b24ee9c7d8
Autor:
Declan T Bradley, Thomas W Bourke, Derek J Fairley, Raymond Borrow, Michael D Shields, Peter F Zipfel, Anne E Hughes
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120757 (2015)
Neisseria meningitidis can cause severe infection in humans. Polymorphism of Complement Factor H (CFH) is associated with altered risk of invasive meningococcal disease (IMD). We aimed to find whether polymorphism of other complement genes altered ri
Externí odkaz:
https://doaj.org/article/a132c76cb3814764850efb788597a855
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138398 (2015)
Externí odkaz:
https://doaj.org/article/1e5b1e83c5254cb69642843f3820dbbb
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0113192 (2015)
Candida albicans, the important human fungal pathogen uses multiple evasion strategies to control, modulate and inhibit host complement and innate immune attack. Clinical C. albicans strains vary in pathogenicity and in serum resistance, in this work
Externí odkaz:
https://doaj.org/article/3ef3c228ea094b30b3006a8b9ebff8ae
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0134418 (2015)
Acinetobacter baumannii is an important nosocomial pathogen, causing a variety of opportunistic infections of the skin, soft tissues and wounds, urinary tract infections, secondary meningitis, pneumonia and bacteremia. Over 63% of A. baumannii infect
Externí odkaz:
https://doaj.org/article/bea0cc45dd9146bf84248c721b866628
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90796 (2014)
Candida albicans is a major cause of invasive fungal infections worldwide. Upon infection and when in contact with human plasma as well as body fluids the fungus is challenged by the activated complement system a central part of the human innate immu
Externí odkaz:
https://doaj.org/article/e00bd37f75e04ecc989d14e7287910fa
Autor:
Diana Pauly, Benedikt M Nagel, Jörg Reinders, Tobias Killian, Matthias Wulf, Susanne Ackermann, Boris Ehrenstein, Peter F Zipfel, Christine Skerka, Bernhard H F Weber
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96371 (2014)
The complement system is an essential part of the innate immune system by acting as a first line of defense which is stabilized by properdin, the sole known positive regulator of the alternative complement pathway. Dysregulation of complement can pro
Externí odkaz:
https://doaj.org/article/668e1735212442d1b93e41c43585c3f9