Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Peter F Hickey"'
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 10, p e1009524 (2021)
A key benefit of long-read nanopore sequencing technology is the ability to detect modified DNA bases, such as 5-methylcytosine. The lack of R/Bioconductor tools for the effective visualization of nanopore methylation profiles between samples from di
Externí odkaz:
https://doaj.org/article/e66b1c33de7c465ab6b5201c09ba4d01
Autor:
Michael I Love, Charlotte Soneson, Peter F Hickey, Lisa K Johnson, N Tessa Pierce, Lori Shepherd, Martin Morgan, Rob Patro
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 2, p e1007664 (2020)
Correct annotation metadata is critical for reproducible and accurate RNA-seq analysis. When files are shared publicly or among collaborators with incorrect or missing annotation metadata, it becomes difficult or impossible to reproduce bioinformatic
Externí odkaz:
https://doaj.org/article/da9cc4aebd6e4be7bcb1f88ca81d32c9
Autor:
Bhavana Nayer, Jean L. Tan, Yasmin K. Alshoubaki, Yen-Zhen Lu, Julien M. D. Legrand, Sinnee Lau, Nan Hu, Anthony J. Park, Xiao-Nong Wang, Daniela Amann-Zalcenstein, Peter F. Hickey, Trevor Wilson, Gisela A. Kuhn, Ralph Müller, Ajithkumar Vasanthakumar, Shizuo Akira, Mikaël M. Martino
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Regulatory T cells (Tregs) are crucial immune cells for tissue repair and regeneration. However, their potential as a cell-based regenerative therapy is not yet fully understood. Here, we show that local delivery of exogenous Tregs into inju
Externí odkaz:
https://doaj.org/article/f42f79ea96ac4536ad48ec4b75f69576
Autor:
Yasmin K. Alshoubaki, Bhavana Nayer, Yen-Zhen Lu, Ekaterina Salimova, Sin Nee Lau, Jean L. Tan, Daniela Amann-Zalcenstein, Peter F. Hickey, Gonzalo del Monte-Nieto, Ajithkumar Vasanthakumar, Mikaël M. Martino
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Regulatory T cells (Tregs) are key immune regulators that have shown promise in enhancing cardiac repair post-MI, although the mechanisms remain elusive. Here, we show that rapidly increasing Treg number in the circulation post-MI via system
Externí odkaz:
https://doaj.org/article/a905ba98718746ceb7e2cdf602aafd25
BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation
Autor:
Andrew Keniry, Natasha Jansz, Linden J. Gearing, Iromi Wanigasuriya, Joseph Chen, Christian M. Nefzger, Peter F. Hickey, Quentin Gouil, Joy Liu, Kelsey A. Breslin, Megan Iminitoff, Tamara Beck, Andres Tapia del Fierro, Lachlan Whitehead, Andrew Jarratt, Sarah A. Kinkel, Phillippa C. Taberlay, Tracy Willson, Miha Pakusch, Matthew E. Ritchie, Douglas J. Hilton, Jose M. Polo, Marnie E. Blewitt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Female embryonic stem cells (ESCs) are the ideal model to study X chromosome inactivation (XCI) establishment; however, these cells are challenging to keep in culture. Here the authors create fluorescent ‘Xmas’ reporter mice as a renewable source
Externí odkaz:
https://doaj.org/article/55d8f97f36464af78639b6d7c2a5c371
Autor:
Yue You, Xueyi Dong, Yong Kiat Wee, Mhairi J. Maxwell, Monther Alhamdoosh, Gordon K. Smyth, Peter F. Hickey, Matthew E. Ritchie, Charity W. Law
Publikováno v:
Genome Biology. 24
Autor:
Yue You, Xueyi Dong, Yong Kiat Wee, Mhairi J. Maxwell, Monther Alhamdoosh, Gordon K. Smyth, Peter F. Hickey, Matthew E. Ritchie, Charity W. Law
Publikováno v:
Genome Biology. 24
Group heteroscedasticity is commonly observed in pseudo-bulk single-cell RNA-seq datasets and its presence can hamper the detection of differentially expressed genes. Since most bulk RNA-seq methods assume equal group variances, we introduce two new
Autor:
Natasha Jansz, Tatyana Nesterova, Andrew Keniry, Megan Iminitoff, Peter F. Hickey, Greta Pintacuda, Osamu Masui, Simon Kobelke, Niall Geoghegan, Kelsey A. Breslin, Tracy A. Willson, Kelly Rogers, Graham F. Kay, Archa H. Fox, Haruhiko Koseki, Neil Brockdorff, James M. Murphy, Marnie E. Blewitt
Publikováno v:
Cell Reports, Vol 25, Iss 7, Pp 1912-1923.e9 (2018)
Summary: We and others have recently reported that the SMC protein Smchd1 is a regulator of chromosome conformation. Smchd1 is critical for the structure of the inactive X chromosome and at autosomal targets such as the Hox genes. However, it is unkn
Externí odkaz:
https://doaj.org/article/8b5a478bdc0c47a7b33d42a0cb4ad8e0
Autor:
Justin P. Rubio, Matthew A. Brown, Sharon R. Browning, Bruce V. Taylor, Peter F. Hickey, Patrick Danoy, Jim Stankovich, Melanie Bahlo
As of June 2009, 361 genome-wide association studies (GWAS) had been referenced by the HuGE database. GWAS require DNA from many thousands of individuals, relying on suitable DNA collections. We recently performed a multiple sclerosis (MS) GWAS where
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c273e0a6f6158c939a184cc6ddd221c
https://doi.org/10.1158/1055-9965.c.6515103.v1
https://doi.org/10.1158/1055-9965.c.6515103.v1
Autor:
Justin P. Rubio, Matthew A. Brown, Sharon R. Browning, Bruce V. Taylor, Peter F. Hickey, Patrick Danoy, Jim Stankovich, Melanie Bahlo
Supplementary Figures 1-5, Supplementary Tables 1-3, Full List of Authors and Affiliations from Saliva-Derived DNA Performs Well in Large-Scale, High-Density Single-Nucleotide Polymorphism Microarray Studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8581263ec7b7bd113e364a5653f4d17
https://doi.org/10.1158/1055-9965.22435788
https://doi.org/10.1158/1055-9965.22435788