Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation.

Autor: Marco van Eijk, Jan Aten, Nora Bijl, Roelof Ottenhoff, Cindy P A A van Roomen, Peter F Dubbelhuis, Ingar Seeman, Karen Ghauharali-van der Vlugt, Hermen S Overkleeft, Cynthia Arbeeny, Albert K Groen, Johannes M F G Aerts

Publikováno v: PLoS ONE, Vol 4, Iss 3, p e4723 (2009)

Adipose tissue is a critical mediator in obesity-induced insulin resistance. Previously we have demonstrated that pharmacological lowering of glycosphingolipids and subsequently GM3 by using the iminosugar AMP-DNM, strikingly improves glycemic contro

Externí odkaz: https://doaj.org/article/4de7292dc62c4bccba10a1b9b8fc6b87

Amino acid signalling and the integration of metabolism

Autor: Alfred J. Meijer, Peter F. Dubbelhuis

Publikováno v: Biochemical and biophysical research communications, 313(2), 397-403. Academic Press Inc.

It has become clear in recent years that amino acids are not only important as substrates for various metabolic pathways but that they can also activate a nutrient-sensitive, mTOR-mediated, signalling pathway in synergy with insulin. Leucine is the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0c821646aa6106311c707508190c40
https://doi.org/10.1016/j.bbrc.2003.07.012

Amino-acid-dependent signal transduction

Autor: Daphne A. VAN SLUIJTERS, Peter F. DUBBELHUIS, Edward F. C. BLOMMAART, Alfred J. MEIJER

Publikováno v: Biochemical Journal. 351:545-550

Recent research carried out in several laboratories has indicated that, in addition to their role as intermediates in many metabolic pathways, amino acids can interact with insulin-dependent signal transduction. In this short review, the current stat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0087d38d4733cae2c2afe826443fd611
https://doi.org/10.1042/bj3510545

Pharmacological Inhibition of Glucosylceramide Synthase Enhances Insulin Sensitivity

Autor: Folkert Kuipers, Roelof Ottenhoff, Tom Wennekes, Johannes M. F. G. Aerts, Marco van Eijk, Jaswinder K. Sethi, Aldo Grefhorst, Mireille J. Serlie, Andrew S. Powlson, Peter F. Dubbelhuis, Hermen S. Overkleeft, Jan Aten, Stephen O'Rahilly

Publikováno v: Diabetes, 56(5), 1341-1349. American Diabetes Association Inc.
Diabetes, 56(5), 1341-1349. AMER DIABETES ASSOC

A growing body of evidence implicates ceramide and/or its glycosphingolipid metabolites in the pathogenesis of insulin resistance. We have developed a highly specific small molecule inhibitor of glucosylceramide synthase, an enzyme that catalyzes a n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d999666fd85c4c0b9d7aa861d2b0210
https://europepmc.org/articles/PMC4298701/

AMP-activated protein kinase and the regulation of autophagic proteolysis

Autor: Judith H.P.M. Houben-Weerts, Peter F. Dubbelhuis, Alfred J. Meijer, Mariette T.J. Helmond, Daniel Meley, Patrice Codogno, Chantal Bauvy

Publikováno v: Journal of biological chemistry, 281(46), 34870-34879. American Society for Biochemistry and Molecular Biology Inc.
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2006, 281 (46), pp.34870-9. ⟨10.1074/jbc.M605488200⟩

Interruption of mTOR-dependent signaling by rapamycin is known to stimulate autophagy, both in mammalian cells and in yeast. Because activation of AMPK also inhibits mTOR-dependent signaling one would expect stimulation of autophagy by AMPK activatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed35e4ca3012c803903b2352a483514
https://pure.amc.nl/en/publications/ampactivated-protein-kinase-and-the-regulation-of-autophagic-proteolysis(6a6e28e1-c0ea-48c0-b6d9-31c8c989ec94).html