Enhanced long-term potentiation in the hippocampus of rats expressing mutant presenillin-1 is age related

Autor: Ruth Pybus, Eleanor Barnard, Peter Estibeiro, John Mullins, Nikki MacLeod

Publikováno v: Neurobiology of Disease, Vol 12, Iss 3, Pp 212-224 (2003)

Electrophysiological recordings were made from Fischer rats engineered to express the human presenilin 1 gene carrying the M146V mutation. Extracellular recordings of field excitatory post-synaptic potential (EPSPs) were made to investigate EPSP prop

Externí odkaz: https://doaj.org/article/d2f7a50b0dfc4e16a05d5956334ffb0a

The use of nucleic acid tools for target validation in central nervous system therapy

Autor: Adrian Fraser, Jenny Godfray, Eleanor Barnard, David Page, Peter Estibeiro

Publikováno v: Drug Discovery Today: Technologies. 1:85-91

The main challenge facing target validation today comes from the ongoing genomics revolution, which is generating an unprecedented number of potential targets. Existing technologies, such as mouse knockouts, are struggling to provide the throughput n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c24c5afa759db78234e9cb6ee537d9
https://doi.org/10.1016/j.ddtec.2004.06.003

Impact of different ChIP-Seq protocols on DNA integrity and quality of bioinformatics analysis results

Autor: Carlo Gaetano, Simona Nanni, Armando Felsani, Antonella Farsetti, Maurizio C. Capogrossi, Peter Estibeiro, Bjarki Gudmundsson, Anna Moles, Hans Guttormur Thormar, Elena Brini, Alessandro Guffanti, Jon J. Jonsson

Publikováno v: Briefings in functional genomics & proteomics
(2014). doi:10.1093/bfgp/elu001
info:cnr-pdr/source/autori:Felsani A.; Gudmundsson B.; Nanni S.; Brini E.; Moles A.; Thormar HG.; Estibeiro P.; Gaetano C.; Capogrossi M.; Farsetti A.; Jonsson J.J.; Guffanti A./titolo:Impact of different ChIP-Seq protocols on DNA integrity and quality of bioinformatics analysis results/doi:10.1093%2Fbfgp%2Felu001/rivista:Briefings in functional genomics & proteomics (Print)/anno:2014/pagina_da:/pagina_a:/intervallo_pagine:/volume

Different ChIP-Seq protocols may have a significant impact on the final outcome in terms of quality, number and distribution of called peaks. Sample DNA undergoes a long procedure before the final sequencing step, and damaged DNA can result in excess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc5695aa1087f155804afd9c153c69f
https://pubmed.ncbi.nlm.nih.gov/24562761

Sequence specificity of single-stranded DNA-binding proteins: a novel DNA microarray approach

Autor: Klaas E.A. Max, Hugh P. Morgan, Peter Estibeiro, Malcolm D. Walkinshaw, Liza Cubeddu, Maurice P. Gallagher, Martin A. Wear, Peter J. Sadler, Udo Heinemann

Publikováno v: Nucleic Acids Research
Morgan, H P, Estibeiro, P, Wear, M A, Max, K E A, Heinemann, U, Cubeddu, L, Gallagher, M P, Sadler, P J & Walkinshaw, M D 2007, ' Sequence specificity of single-stranded DNA-binding proteins : a novel DNA microarray approach ', Nucleic Acids Research, vol. 35, no. 10, e75 . https://doi.org/10.1093/nar/gkm040

We have developed a novel DNA microarray-based approach for identification of the sequence-specificity of single-stranded nucleic-acid-binding proteins (SNABPs). For verification, we have shown that the major cold shock protein (CspB) from Bacillus s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0876dcd3fedd3dd055e118025b4194b
https://pubmed.ncbi.nlm.nih.gov/17488853

The potential of antisense as a CNS therapeutic

Autor: Jenny Godfray, Peter Estibeiro

Publikováno v: Expert opinion on therapeutic targets. 7(3)

Antisense offers a precise and specific means of knocking down expression of a target gene, and is a major focus of research in neuroscience and other areas. It has application as a tool in gene function and target validation studies and is emerging

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c2a6ba429f67bc6a2209286b913349
https://pubmed.ncbi.nlm.nih.gov/12783572