Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Peter Eddershaw"'
Development of a small molecule that corrects misfolding and increases secretion of Z α1‐antitrypsin
Autor:
David A Lomas, James A Irving, Christopher Arico‐Muendel, Svetlana Belyanskaya, Andrew Brewster, Murray Brown, Chun‐wa Chung, Hitesh Dave, Alexis Denis, Nerina Dodic, Anthony Dossang, Peter Eddershaw, Diana Klimaszewska, Imran Haq, Duncan S Holmes, Jonathan P Hutchinson, Alistair M Jagger, Toral Jakhria, Emilie Jigorel, John Liddle, Ken Lind, Stefan J Marciniak, Jeff Messer, Margaret Neu, Allison Olszewski, Adriana Ordonez, Riccardo Ronzoni, James Rowedder, Martin Rüdiger, Steve Skinner, Kathrine J Smith, Rebecca Terry, Lionel Trottet, Iain Uings, Steve Wilson, Zhengrong Zhu, Andrew C Pearce
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 3, Pp 1-16 (2021)
Abstract Severe α1‐antitrypsin deficiency results from the Z allele (Glu342Lys) that causes the accumulation of homopolymers of mutant α1‐antitrypsin within the endoplasmic reticulum of hepatocytes in association with liver disease. We have use
Externí odkaz:
https://doaj.org/article/73075a476ae1421891a994ecbcb35e20
Autor:
Licong Jiang, Sanjeev Kumar, Marc Nuechterlein, Marissa Reyes, Dao Tran, Clifford Cabebe, Peggy Chiang, James Reynolds, Scott Carrier, Yongkai Sun, Peter Eddershaw, Tanya Hay, Weichao Chen, Bo Feng
Publikováno v:
Pharmacology Research & Perspectives, Vol 10, Iss 1, Pp n/a-n/a (2022)
Abstract P‐glycoprotein (P‐gp, MDR1) is expressed at the blood–brain barrier (BBB) and restricts penetration of its substrates into the central nervous system (CNS). In vitro MDR1 assays are frequently used to predict the in vivo relevance of M
Externí odkaz:
https://doaj.org/article/5ad250f2f08541b7bd83cab4d6b1d30c
Autor:
Carl Petersson, Xin Zhou, Joerg Berghausen, David Cebrian, Michael Davies, Kevin DeMent, Peter Eddershaw, Arian Emami Riedmaier, Alix F. Leblanc, Nenad Manveski, Punit Marathe, Panteleimon D. Mavroudis, Robin McDougall, Neil Parrott, Andreas Reichel, Charles Rotter, David Tess, Laurie P. Volak, Guangqing Xiao, Zheng Yang, James Baker
Publikováno v:
The AAPS journal. 24(5)
Accurate prediction of human clearance (CL) and volume of distribution at steady state (V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad0355b8129b644057e17db59643707
https://pubmed.ncbi.nlm.nih.gov/35854202
https://pubmed.ncbi.nlm.nih.gov/35854202
Autor:
Martin Rüdiger, Chun-wa Chung, Jonathan P. Hutchinson, Christopher C. Arico-Muendel, Svetlana L. Belyanskaya, Allison Olszewski, Nerina Dodic, Duncan S. Holmes, Anthony Dossang, Andrew C. Pearce, Alistair M. Jagger, Steve Wilson, Adriana Ordóñez, David A. Lomas, Toral Jakhria, Iain Uings, Hitesh Dave, Zhengrong Zhu, Stefan J. Marciniak, Alexis Denis, Lionel Trottet, Kathrine J. Smith, Murray J. B. Brown, Imran Haq, James A. Irving, Steve Skinner, Margaret Neu, Diana Klimaszewska, Peter Eddershaw, Riccardo Ronzoni, James E. Rowedder, Andrew Brewster, John Liddle, Emilie Jigorel, Jeffrey A. Messer, Ken Lind, Rebecca Terry
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 13, Iss 3, Pp n/a-n/a (2021)
EMBO Molecular Medicine, Vol 13, Iss 3, Pp n/a-n/a (2021)
Severe α1‐antitrypsin deficiency results from the Z allele (Glu342Lys) that causes the accumulation of homopolymers of mutant α1‐antitrypsin within the endoplasmic reticulum of hepatocytes in association with liver disease. We have used a DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e32df3c3fc2fd491449ec31b9633ea9
https://doi.org/10.15252/emmm.202013167
https://doi.org/10.15252/emmm.202013167
Autor:
John, Liddle, Andrew C, Pearce, Christopher, Arico-Muendel, Svetlana, Belyanskaya, Andrew, Brewster, Murray, Brown, Chun-Wa, Chung, Alexis, Denis, Nerina, Dodic, Anthony, Dossang, Peter, Eddershaw, Diana, Klimaszewska, Imran, Haq, Duncan S, Holmes, Alistair, Jagger, Toral, Jakhria, Emilie, Jigorel, Ken, Lind, Jeff, Messer, Margaret, Neu, Allison, Olszewski, Riccardo, Ronzoni, James, Rowedder, Martin, Rüdiger, Steve, Skinner, Kathrine J, Smith, Lionel, Trottet, Iain, Uings, Zhengrong, Zhu, James A, Irving, David A, Lomas
Publikováno v:
Bioorganicmedicinal chemistry letters. 41
α1-antitrypsin deficiency is characterised by the misfolding and intracellular polymerisation of mutant α1-antitrypsin protein within the endoplasmic reticulum (ER) of hepatocytes. Small molecules that bind and stabilise Z α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bfbd08c9f4609860ae0edd678ca66212
https://pubmed.ncbi.nlm.nih.gov/33753261
https://pubmed.ncbi.nlm.nih.gov/33753261
Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin
Autor:
Stefan J. Marciniak, Martin Rüdiger, Hitesh Dave, Jonathan P. Hutchinson, Margaret Neu, Anthony Dossang, Riccardo Ronzoni, Lionel Trottet, Adriana Ordóñez, Chun-wa Chung, Christopher C. Arico-Muendel, Alexis Denis, Allison Olszewski, Andrew C. Pearce, Ken Lind, Peter Eddershaw, Andrew Brewster, Rebecca Terry, Jeffrey A. Messer, John Liddle, Iain Uings, Emilie Jigorel, James A. Irving, Nerina Dodic, Zhengrong Zhu, Kathrine J. Smith, Duncan S. Holmes, Steve Skinner, Steve Wilson, David A. Lomas, Diana Klimaszewska, James E. Rowedder, Murray J. B. Brown, Alistair M. Jagger, Toral Jakhria, Imran Haq, Svetlana L. Belyanskaya
Severe α1-antitrypsin deficiency results from the Z allele (Glu342Lys) that causes the accumulation of homopolymers of mutant α1-antitrypsin within the endoplasmic reticulum of hepatocytes in association with liver disease. We have used a DNA-encod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af5dc4b6dd1fbecffcf82db1f278226c
https://doi.org/10.1101/2020.07.26.217661
https://doi.org/10.1101/2020.07.26.217661
Autor:
Lionel Trottet, Martin Rüdiger, Anthony Dossang, Alexis Denis, David A. Lomas, James A. Irving, Andrew C. Pearce, Andrew Brewster, John Liddle, Zhengrong Zhu, Peter Eddershaw, James E. Rowedder, Kathrine J. Smith, Chun-wa Chung, Ken Lind, Christopher C. Arico-Muendel, Jeffrey A. Messer, Allison Olszewski, Diana Klimaszewska, Murray J. B. Brown, Nerina Dodic, Duncan S. Holmes, Imran Haq, Alistair M. Jagger, Toral Jakhria, Steve Skinner, Margaret Neu, Riccardo Ronzoni, Emilie Jigorel, Iain Uings, Svetlana L. Belyanskaya
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 41:127973
α1-antitrypsin deficiency is characterised by the misfolding and intracellular polymerisation of mutant α1-antitrypsin protein within the endoplasmic reticulum (ER) of hepatocytes. Small molecules that bind and stabilise Z α1-antitrypsin were iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d246fffa8ad97002689f34f62901b59
https://doi.org/10.1016/j.bmcl.2021.127973
https://doi.org/10.1016/j.bmcl.2021.127973
Autor:
Haruo Usuda, Demelza J. Ireland, Takushi Hanita, Lucy L. Furfaro, Michael W. Clarke, Matthew S. Payne, Gabrielle C. Musk, Timothy J. Molloy, Yusaku Kumagai, Masatoshi Saito, Matthew W. Kemp, Peter Eddershaw, John P. Newnham, Alan H. Jobe, Augusto F. Schmidt, Shimpei Watanabe, Shinichi Sato
Publikováno v:
American journal of obstetrics and gynecology. 219(3)
Background Antenatal corticosteroids are among the most important and widely used interventions to improve outcomes for preterm infants. Antenatal corticosteroid dosing regimens remain unoptimized and without maternal weight-adjusted dosing. We, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12eb2ee28c9251a5e2686ef5ad17f99
https://pubmed.ncbi.nlm.nih.gov/30792024
https://pubmed.ncbi.nlm.nih.gov/30792024
Publikováno v:
Pharmaceutical Research
Purpose To examine if pulmonary P-glycoprotein (P-gp) is functional in an intact lung; impeding the pulmonary absorption and increasing lung retention of P-gp substrates administered into the airways. Using calculated physico-chemical properties alon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6abb25b829f8dc702e0781843e248379
https://pubmed.ncbi.nlm.nih.gov/28702798
https://pubmed.ncbi.nlm.nih.gov/28702798
Autor:
Christopher J. Morris, Glyn Taylor, Mathew W. Smith, Peter Eddershaw, Daniel F. Price, Ghaith Aljayyoussi, Chris D. Edwards, Mark Gumbleton, Danielle Francombe
Publikováno v:
Journal of Pharmaceutical Sciences. 102:3382-3394
P-glycoprotein (P-gp) mediated efflux is recognised to alter the absorption and disposition of a diverse range of substrates. Despite evidence showing the presence of P-gp within the lung, relatively little is known about the transporter's effect upo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bed12dca31938a7b02f9b3632d2d10d
https://doi.org/10.1002/jps.23587
https://doi.org/10.1002/jps.23587