Zobrazeno 1 - 10
of 432
pro vyhledávání: '"Peter E. Wright"'
Autor:
Tom L. Blundell, Peter E. Wright
Publikováno v:
Current Research in Structural Biology, Vol 4, Iss , Pp iv- (2022)
Externí odkaz:
https://doaj.org/article/637acad2caa24c1e82e5c39bf5a5f145
Publikováno v:
Biochemistry. 61:2709-2719
The C-terminal region of the tumor suppressor protein p53 contains three domains, nuclear localization signal (NLS), tetramerization domain (TET), and C-terminal regulatory domain (CTD), which are essential for p53 function. Characterization of the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba774f0a57c83bb026e877d84748778
https://doi.org/10.1021/acs.biochem.2c00528
https://doi.org/10.1021/acs.biochem.2c00528
Publikováno v:
The Journal of Physical Chemistry B. 126:9539-9548
The earliest events in the folding of a protein are in general poorly understood. We used NMR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8cc770ea42eb5a0623b17025b3ba2ac
https://doi.org/10.1021/acs.jpcb.2c05592
https://doi.org/10.1021/acs.jpcb.2c05592
Publikováno v:
Nucleic Acids Research. 50:7147-7160
Protein dynamics involving higher-energy sparsely populated conformational substates are frequently critical for protein function. This study describes the dynamics of the homodimer (p50)2 of the p50 Rel homology region (RHR) of the transcription fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a09c5a5e112eb1d2dd83344a2d60046
https://doi.org/10.1093/nar/gkac535
https://doi.org/10.1093/nar/gkac535
Autor:
H. Jane Dyson, Peter E. Wright
Publikováno v:
Israel Journal of Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99196139648c7aaf37f4c8e909bc84ff
https://doi.org/10.1002/ijch.202300051
https://doi.org/10.1002/ijch.202300051
Autor:
Tom L. Blundell, Peter E. Wright
Publikováno v:
Current research in structural biology. 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3061421c1b807f565ca9477f270ddd88
https://pubmed.ncbi.nlm.nih.gov/36588539
https://pubmed.ncbi.nlm.nih.gov/36588539
Publikováno v:
FEBS letters.
The cyclic AMP Response Element Binding Protein (CREB) contains a basic leucine zipper motif (bZIP) that forms a coiled coil structure upon dimerization and specific DNA binding. Although this state is well characterized, key features of CREB bZIP bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2705db38a7212bcd9d0d7a448ad51ac0
https://pubmed.ncbi.nlm.nih.gov/36480418
https://pubmed.ncbi.nlm.nih.gov/36480418
Publikováno v:
Biochemistry. 60:2663-2671
Conformational fluctuations from ground-state to sparsely populated but functionally important excited states play a key role in enzyme catalysis. For Escherichia coli dihydrofolate reductase (DHFR), the release of the product tetrahydrofolate (THF)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccfb263095072eb94c693763dac4e9e8
https://doi.org/10.1021/acs.biochem.1c00461
https://doi.org/10.1021/acs.biochem.1c00461
Publikováno v:
Current Opinion in Chemical Biology. 73:102280
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::026b1901124f1bc896b07bd7e5b1a11f
https://doi.org/10.1016/j.cbpa.2023.102280
https://doi.org/10.1016/j.cbpa.2023.102280
Publikováno v:
The Journal of biological chemistry. 298(8)
Transthyretin (TTR) amyloidosis is associated with tissue deposition of TTR aggregates. TTR aggregation is initiated by dissociation of the native tetramer to form a monomeric intermediate, which locally unfolds and assembles into soluble oligomers a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2981c364b3fb9973f5b54e5a4d1d55bf
https://pubmed.ncbi.nlm.nih.gov/35724960
https://pubmed.ncbi.nlm.nih.gov/35724960