Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Peter E. Hutchinson"'
Autor:
Peter E, Hutchinson, James H, Pringle
Publikováno v:
Pigment Cell & Melanoma Research. 35:408-424
Epidemiological studies indicate that Vitamin D has a beneficial, inhibitory effect on cancer development and subsequent progression, including melanoma (MM), and favourable MM outcome has been reported as directly related to vitamin D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77dc93a74df6bcce54dd83480cb6fbf5
https://doi.org/10.1111/pcmr.13040
https://doi.org/10.1111/pcmr.13040
Autor:
Silvia Popovici, Gerald Saldanha, J.H. Pringle, Deepthi Dasari, Peter E. Hutchinson, Ian R. Powley, Eftychios Papadogeorgakis, John A. Halsall, J.E. Osborne
Publikováno v:
Melanoma research. 28(5)
The aims of this study were to investigate, in cutaneous malignant melanoma (MM), the integrity of nuclear vitamin D receptor (VDR) signalling, as implied by VDR subcellular location; to investigate the relationship between VDR and tumour progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c2d366efa5bebcd3b3cb7f4cc0c11c
https://pubmed.ncbi.nlm.nih.gov/30004989
https://pubmed.ncbi.nlm.nih.gov/30004989
Autor:
Joël Lachuer, Gina Tse, Gerald Saldanha, Anne Wierinckx, Stéphane Ansieau, Peter E. Hutchinson, Eftychios Papadogeorgakis, Eugene Tulchinsky, Alain Puisieux, J.E. Osborne, Louise Hill, Julie Caramel, Geoffrey Richard, Gareth J. Browne, J. Howard Pringle
Publikováno v:
Cancer Cell. 24:466-480
SummaryAberrant expression of embryonic epithelial-mesenchymal transition-inducing transcription factors (EMT-TFs) in epithelial cells triggers EMT, neoplastic transformation, stemness, and metastatic dissemination. We found that regulation and funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91d4e1fb45822df04cd56299deb73ba
https://doi.org/10.1016/j.ccr.2013.08.018
https://doi.org/10.1016/j.ccr.2013.08.018
Publikováno v:
Dermato-Endocrinology. 1:54-57
The A allele of the A-1012G (rs4516035) vitamin D receptor (VDR) promoter polymorphism is associated with increased susceptibility and worsened outcome in malignant melanoma (MM). The A allele contains a GATA-3 binding site. There is a second polymor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e41704b4d6562c643effdf85cccbef
https://doi.org/10.4161/derm.1.1.7674
https://doi.org/10.4161/derm.1.1.7674
Autor:
Joy Osborn, Gerald Saldanha, Peter E. Hutchinson, Qiang Huang, A. Fletcher, J. Howard Pringle, Rachael A. Hancox, Linda Potter, Philip D. Da Forno
Publikováno v:
Clinical Cancer Research. 14:5825-5832
Purpose: Wnt ligands play a major role in development and are important in cancer. Expression microarray analysis correlates one member of this family, WNT5A, to a subclass of melanomas with increased motility and invasion. There are no large studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c69387f15c1841b2c97856e6d3d90e4
https://doi.org/10.1158/1078-0432.ccr-07-5104
https://doi.org/10.1158/1078-0432.ccr-07-5104
Publikováno v:
British Journal of Dermatology. 153:241-253
Toxic epidermal necrolysis (TEN) is a rare disorder characterized by extensive epidermal death. Almost all cases appear to be caused by an idiosyncratic drug reaction. Proposed pathogenic mechanisms are conflicting, and the evidence for the benefits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ebf757a0f695d51f2cb7e13cec5d9a
https://doi.org/10.1111/j.1365-2133.2005.06721.x
https://doi.org/10.1111/j.1365-2133.2005.06721.x
Publikováno v:
British Journal of Dermatology. 153:103-112
Summary Background Hair loss from cytotoxic drugs is classically ascribed to the loss of fractured hairs (anagen effluvium). Telogen hair loss has also been described but some authors have denied any effect on the hair cycle. There are conflicting re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee7ff4ba15d77ab5d8b054a76a6013d6
https://doi.org/10.1111/j.1365-2133.2005.06608.x
https://doi.org/10.1111/j.1365-2133.2005.06608.x
Publikováno v:
Pharmacogenetics and Genomics. 15:349-355
Psoriasis is a genetically determined disease characterized by hyperproliferation and disordered maturation of the epidermis. Th1 lymphocytes are implicated in its pathogenesis. The vitamin D receptor (VDR) is a candidate modifying gene, having immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d570b9020b47e6a60a37c7aafef5adc9
https://doi.org/10.1097/01213011-200505000-00011
https://doi.org/10.1097/01213011-200505000-00011
Publikováno v:
British Journal of Cancer
The association of Taq 1 and Fok 1 restriction fragment length polymorphisms of the vitamin D receptor with occurrence and outcome of malignant melanoma (MM), as predicted by tumour (Breslow) thickness, has been reported previously. We now report a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ad2f7f5ef347a56aa77516e537f9ae
http://europepmc.org/articles/PMC2364794
http://europepmc.org/articles/PMC2364794
Autor:
Marcus S. Cooke, Peter E. Hutchinson, Mark D. Evans, Ian D. Podmore, Joseph Lunec, Aikaterini Karakoula
Publikováno v:
Journal of Immunological Methods. 277:27-37
The induction and repair of DNA damage has been shown to occur heterogeneously throughout the mammalian genome. As a consequence, analysis of these parameters at a global genome level may not reflect important gene-level events. Few techniques have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97844e6acf640baf637637f6b35ced1c
https://doi.org/10.1016/s0022-1759(03)00122-4
https://doi.org/10.1016/s0022-1759(03)00122-4