Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Peter E. Grebow"'
Autor:
Peter E. Grebow, Watson B. Laughton, George C. McCormick, S Gorman, S P King, Donna Simcoe, Y N Wong
Publikováno v:
The Journal of Clinical Pharmacology. 39:281-288
An open-label, single-center, single-dose, parallel-group study was performed in healthy young males and females as well as healthy elderly males to examine the influence of age and gender on the pharmacokinetics of modafinil following administration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c09daa8306a95c2a7cf3c9264d937dd3
https://doi.org/10.1177/009127009903900312
https://doi.org/10.1177/009127009903900312
Autor:
Peter E. Grebow, Watson B. Laughton, Y. Nancy Wong, George C. McCormick, Linda N. Hartman, S. Peter King, Donna Simcoe
Publikováno v:
The Journal of Clinical Pharmacology. 39:30-40
A randomized, double-blind, placebo-controlled, ascending-dose study was conducted to evaluate the pharmacokinetic and safety profiles of increasing modafinil doses (200 mg, 400 mg, 600 mg, 800 mg) administered orally over a 7-day period in normal he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4493357a686b5052ca3ed4a0b7da2b38
https://doi.org/10.1177/00912709922007534
https://doi.org/10.1177/00912709922007534
Autor:
Watson B. Laughton, Donna Simcoe, Yusong Chen, Linda N. Hartman, Richard Eldon, Peter E. Grebow, Colin Markland, Lixia Wang, Y. Nancy Wong
Publikováno v:
The Journal of Clinical Pharmacology. 38:971-978
An open-label, randomized, crossover study was performed in healthy male volunteers to evaluate the potential pharmacokinetic and pharmacodynamic interactions and tolerability of single oral doses of modafinil (200 mg) and dextroamphetamine (10 mg).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db5b3ac82c842bc4418503f11fc08b8
https://doi.org/10.1002/j.1552-4604.1998.tb04395.x
https://doi.org/10.1002/j.1552-4604.1998.tb04395.x
Autor:
Nicola Neff, Peter E. Grebow, Frank Baldino, Kathleen V. Callison, Jeffry L. Vaught, Michael E. Lewis, Patricia C. Contreras, Erya Yu
Publikováno v:
Annals of the New York Academy of Sciences. 692:201-208
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd274f688a5c960598b2c5982da2876a
https://doi.org/10.1111/j.1749-6632.1993.tb26218.x
https://doi.org/10.1111/j.1749-6632.1993.tb26218.x
Publikováno v:
Journal of clinical pharmacology. 38(3)
Modafinil is a novel wake-promoting agent being developed for treatment of excessive daytime sleepiness associated with narcolepsy. An open, 3 x 3 Latin square, randomized, cross-over study was performed in healthy males to compare the pharmacokineti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef763e375e0e35e6ff13fd74727f77cd
https://pubmed.ncbi.nlm.nih.gov/9549666
https://pubmed.ncbi.nlm.nih.gov/9549666
Autor:
Jeffry L. Vaught, Ronald W. Oppenheim, Patricia C. Contreras, Michael E. Lewis, Nicola Neff, Peter E. Grebow, David Stong
Publikováno v:
Experimental neurology. 124(1)
Motor neuronal disorders, such as the loss of spinal cord motor neurons in amyotrophic lateral sclerosis or the degeneration of spinal cord motor neuron axons in certain peripheral neuropathies, present a unique opportunity for therapeutic interventi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38d47692905e8417d798f4dac0884516
https://pubmed.ncbi.nlm.nih.gov/8282084
https://pubmed.ncbi.nlm.nih.gov/8282084
Publikováno v:
Agents and Actions. 9:265-274
Leukokinin-H, a pharmacologically active peptide, has been isolated from human ascites fluid following its generation in vitro at acid pH. The peptide has a molecular weight of approximately 2500. The partial sequence of Leu-Ala-Tyr-Thr — was obtai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ef50e9c53d75d3f882deb8c30ea03d
https://doi.org/10.1007/bf01966699
https://doi.org/10.1007/bf01966699
Publikováno v:
Current Medical Research and Opinion. 5:9-12
SummaryA fluorescence assay for indapamide which is both sensitive and capable of handling large numbers of samples has been developed. Reaction of indapamide with NaOH at 100°C has been shown to yield a fluorescent product, which has excitation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d51aa3b40ca208bdde884d24db095f44
https://doi.org/10.1185/03007997709110218
https://doi.org/10.1185/03007997709110218
Autor:
Peter E. Grebow, Thomas M. Hooker
Publikováno v:
Biopolymers. 13:2349-2366
Semiempirical conformational energy calculations were carried out for the cyclic dipeptide L-alanyl-L-histidine diketopiperazine. The results indicate that electrostatic effects are probably significant in determining the conformation assumed by this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e799f9b41a4cab696078c61678e2d890
https://doi.org/10.1002/bip.1974.360131115
https://doi.org/10.1002/bip.1974.360131115
Autor:
Peter E. Grebow, Ira Weinryb
Publikováno v:
Clinical Research Practices and Drug Regulatory Affairs. 2:1-10
A number of issues arising from some current trends in the practice of clinical pharmacokinetics are discussed. These include considerations of pharmacokinetic analysis, bioavailability, possible complications of active metabolites, assay validation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79fd6fdc40760811b7db7b438984e7f8
https://doi.org/10.3109/10601338409027320
https://doi.org/10.3109/10601338409027320