Zobrazeno 1 - 10
of 603
pro vyhledávání: '"Peter E, Nielsen"'
Publikováno v:
Frontiers in Antibiotics, Vol 3 (2024)
Initiation of chromosome replication is an essential stage of the bacterial cell cycle that is controlled by the DnaA protein. With the aim of developing novel antimicrobials, we have targeted the initiation of DNA replication, using antisense peptid
Externí odkaz:
https://doaj.org/article/46cfcb5c2169412192f7ce3dbbfb8fc4
Autor:
Özgür Öztürk, Anna-Lina Lessl, Miriam Höhn, Stefan Wuttke, Peter E. Nielsen, Ernst Wagner, Ulrich Lächelt
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Ideal drug carriers feature a high loading capacity to minimize the exposure of patients with excessive, inactive carrier materials. The highest imaginable loading capacity could be achieved by nanocarriers, which are assembled from the ther
Externí odkaz:
https://doaj.org/article/d81abb79c1d441adb709f9271d7cca6b
Autor:
Andrea D. Shields, Jacqueline D. Battistelli, Laurie B. Kavanagh, Brook A. Thomson, Peter E. Nielsen
Publikováno v:
BMC Emergency Medicine, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Objective Maternal cardiac arrest is a rare and complex process requiring pregnancy-specific responses and techniques. The goals of this study were to (1) identify, evaluate, and determine the most current best practices to treat this patien
Externí odkaz:
https://doaj.org/article/f81437af82984152bbbc81ca00e983a0
Autor:
Jakob Frimodt-Møller, Andreas Koulouktsis, Godefroid Charbon, Marit Otterlei, Peter E. Nielsen, Anders Løbner-Olesen
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 444-454 (2021)
Cell-penetrating peptides (CPPs) are increasingly used for cellular drug delivery in both pro- and eukaryotic cells, and oligoarginines have attracted special attention. How arginine-rich CPPs translocate across the cell envelope, particularly for pr
Externí odkaz:
https://doaj.org/article/253da9a6a4314fa899fff9d789465764
Autor:
Lise Goltermann, Meiqin Zhang, Anna Elisabeth Ebbensgaard, Marija Fiodorovaite, Niloofar Yavari, Anders Løbner-Olesen, Peter E. Nielsen
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The physical and chemical properties of the outer membrane of Gram-negative bacteria including Escherichia coli have a significant impact on the antibacterial activity and uptake of antibiotics, including antimicrobial peptides and antisense peptide-
Externí odkaz:
https://doaj.org/article/b106ed952cfc43c19c26a64e596a2550
Autor:
Bénédicte Ndeboko, Narayan Ramamurthy, Guy Joseph Lemamy, Catherine Jamard, Peter E. Nielsen, Lucyna Cova
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 9, Iss C, Pp 162-169 (2017)
Peptide nucleic acids (PNAs) are potentially attractive antisense agents against hepatitis B virus (HBV), although poor cellular uptake limits their therapeutic application. In the duck HBV (DHBV) model, we evaluated different cell-penetrating peptid
Externí odkaz:
https://doaj.org/article/36eeb876da62402ea54601da576d55b9
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Peptide Nucleic Acid (PNA)-peptide conjugates targeting essential bacterial genes are showing promise as antisense antimicrobials in drug discovery. Optimization has focused on selection of target genes and exact localization around the ribosome bind
Externí odkaz:
https://doaj.org/article/05caff24802f49a480aab1abcb524e41
Publikováno v:
Biomedicines, Vol 9, Iss 4, p 429 (2021)
Infections by carbapenem-resistant A. baumannii (CRAB), a widespread nosocomial pathogen, are becoming increasingly difficult to prevent and treat. Therefore, there is an urgent need for discovery of novel antibiotics against CRAB. Programmable, prec
Externí odkaz:
https://doaj.org/article/c5d5b9434906412ead69d10dcfcb7ccb
Publikováno v:
Biomolecules, Vol 9, Iss 10, p 554 (2019)
Cellular uptake and antisense activity of d-octaarginine conjugated peptide nucleic acids (PNAs) is shown to exhibit pronounced cooperativity in serum-containing medium, in particular by being enhanced by analogous mis-match PNA−cell-penetrating pe
Externí odkaz:
https://doaj.org/article/2ce51f39d5e54bd38e1aa5a35eca17d7
Autor:
Helen Bergquist, Cristina S J Rocha, Rubén Álvarez-Asencio, Chi-Hung Nguyen, Mark W Rutland, C I Edvard Smith, Liam Good, Peter E Nielsen, Rula Zain
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0165788 (2016)
Expansion of (GAA)n repeats in the first intron of the Frataxin gene is associated with reduced mRNA and protein levels and the development of Friedreich's ataxia. (GAA)n expansions form non-canonical structures, including intramolecular triplex (H-D
Externí odkaz:
https://doaj.org/article/31f002a6d0df4a0a874c8cb555cdc41c