Zobrazeno 1 - 10
of 307
pro vyhledávání: '"Peter E, Lobie"'
Autor:
Liqiong Wang, Xi Zhang, Shu Chen, Qiuhua Ye, Basappa Basappa, Tao Zhu, Peter E. Lobie, Vijay Pandey
Publikováno v:
Translational Oncology, Vol 49, Iss , Pp 102103- (2024)
Objective: Mitomycin C (MMC), a DNA-damaging chemotherapeutic, is commonly used clinically for recurrent cervical carcinoma (CC), either alone or in combination. MMC generates DNA damage resulting in CC cell death yet also induces increased AKT-BAD p
Externí odkaz:
https://doaj.org/article/b248bb94535646d2bef4b5efc0bed8d8
Autor:
Na Young Kim, Dukanya Dukanya, Gautam Sethi, Swamy S Girimanchanaika, Jirui Yang, Omantheswara Nagaraja, Ananda Swamynayaka, Divakar Vishwanath, Keerthikumara Venkantesha, Shreeja Basappa, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Mahendra Madegowda, Alexey Sukhorukov, Vijay Pandey, Peter E. Lobie, Basappa Basappa, Kwang Seok Ahn
Publikováno v:
Translational Oncology, Vol 49, Iss , Pp 102101- (2024)
Small molecule-driven JNK activation has been found to induce apoptosis and paraptosis in cancer cells. Herein pharmacological effects of synthetic oxazine (4aS, 7aS)-3-((4-(4‑chloro-2-fluorophenyl)piperazin-1-yl)methyl)-4-phenyl-4, 4a, 5, 6, 7, 7a
Externí odkaz:
https://doaj.org/article/6719bc3a38394d8688d5d7884b2aea4a
Autor:
Jingchao Sun, Ying Xiao, Wei Xing, Wenjuan Jiang, Xuefeng Hu, Hongchao Li, Zhaojun Liu, Qian Jin, Peng Ren, Hongmei Zhang, Peter E. Lobie
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 116965- (2024)
Background and purpose: GLP-1 receptor agonists are clinically utilized for type 2 diabetes and obesity. In vitro and in vivo preclinical studies were performed to assess the druggability of a novel small molecule GLP-1 receptor biased agonist SAL011
Externí odkaz:
https://doaj.org/article/a51f40fb0a8445d1b98d5441114b45cf
Autor:
Yan Qin Tan, Bowen Sun, Xi Zhang, Shuwei Zhang, Hui Guo, Basappa Basappa, Tao Zhu, Gautam Sethi, Peter E. Lobie, Vijay Pandey
Publikováno v:
Cell Death and Disease, Vol 15, Iss 2, Pp 1-15 (2024)
Abstract Therapeutic targeting of KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) has remained a significant challenge in clinical oncology. Direct targeting of KRAS has proven difficult, and inhibition of the KRAS effectors have shown limited su
Externí odkaz:
https://doaj.org/article/6c51f34c4c554e30809c9c5a3ff25555
Autor:
Yan Qin Tan, Yi-Shiou Chiou, Hui Guo, Shuwei Zhang, Xiaoming Huang, Dukanya Dukanya, Arun M. Kumar, Shreeja Basappa, Suling Liu, Tao Zhu, Basappa Basappa, Vijay Pandey, Peter E. Lobie
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-19 (2024)
Abstract Aberrant activation of the PI3K/AKT signaling axis along with the sustained phosphorylation of downstream BAD is associated with a poor outcome of TNBC. Herein, the phosphorylated to non-phosphorylated ratio of BAD, an effector of PI3K/AKT p
Externí odkaz:
https://doaj.org/article/66e441eb7b2d4580828abd005654979b
Autor:
Mingming Wu, Xiao Zhang, Weijie Zhang, Linlin Yan, Xiangtian Liu, Min Zhang, Yueyin Pan, Peter E. Lobie, Xinghua Han, Tao Zhu
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Breast tumors consist of heterogeneous cellular subpopulations that differ in molecular properties and functional attributes. Cancer stem cells (CSCs) play pivotal roles in cancer therapeutic failure and metastasis. However, it re
Externí odkaz:
https://doaj.org/article/0b547a02f73041d3b32320326e193361
Publikováno v:
Applied Microbiology, Vol 3, Iss 1, Pp 254-264 (2023)
Novel benzoxazines were synthesized by microwave irradiation and tested for their potential binding affinity towards receptors of advanced glycation end products (RAGE). We found that the compound (2-(2-bromophenyl)-6-methyl-2,4-dihydro-1H-benzo[d][1
Externí odkaz:
https://doaj.org/article/01403f621d9c4e8ab1e1764705168107
Autor:
Yuanxiong Cao, Jiayi Tan, Haoran Zhao, Ting Deng, Yunxia Hu, Junhong Zeng, Jiawei Li, Yifan Cheng, Jiyuan Tang, Zhiwei Hu, Keer Hu, Bing Xu, Zitian Wang, Yaojiong Wu, Peter E. Lobie, Shaohua Ma
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Current mesenchymal stem cell (MSC) transplantation practices are limited by the loss or reduced performance of MSCs. Here the authors develop a bead-jet printer for intraoperative formulation and printing of MSCs-laden Matrigel beads to improve skel
Externí odkaz:
https://doaj.org/article/0a68d6a2529540a2ac2e944d9137b981
Autor:
Xi Zhang, Liqiong Wang, Shu Chen, Peng Huang, Lan Ma, Hui Ding, Basappa Basappa, Tao Zhu, Peter E. Lobie, Vijay Pandey
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-16 (2022)
Zhang et al. test the therapeutic potential of an inhibitor of BAD phosphorylation, NPB, in epithelial ovarian cancer. The authors show that the small molecule synergises with PARP inhibition to kill patient-derived ovarian cancer organoids and suppr
Externí odkaz:
https://doaj.org/article/51d8e772fc124202b0fa0bbba42bfde0
Autor:
Xi Zhang, Peng Huang, Liqiong Wang, Shu Chen, Basappa Basappa, Tao Zhu, Peter E. Lobie, Vijay Pandey
Publikováno v:
Cell Death and Disease, Vol 13, Iss 6, Pp 1-12 (2022)
Abstract Loss of phosphatase and tensin homolog (PTEN) impairs DNA double-strand repair and confers sensitivity to poly (ADP-ribose) polymerase inhibitors (PARPis). However, PARPis also hyperactivate the MAPK and PI3K/AKT/mTOR pathways in PTEN-defici
Externí odkaz:
https://doaj.org/article/367d66a0dc4a46e591b41ff79b7d2b66