Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Peter Droge"'
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-16 (2020)
Abstract Background The precise, functional and safe insertion of large DNA payloads into host genomes offers versatility in downstream genetic engineering-associated applications, spanning cell and gene therapies, therapeutic protein production, hig
Externí odkaz:
https://doaj.org/article/d1b6511059e0418e83656e2597bd2673
Autor:
Syed Moiz Ahmed, Peter Dröge
Publikováno v:
Molecular Oncology, Vol 13, Iss 10, Pp 2062-2078 (2019)
Rapidly dividing cells maintain chromatin supercoiling homeostasis via two specialized classes of enzymes, DNA topoisomerase type 1 and 2 (TOP1/2). Several important anticancer drugs perturb this homeostasis by targeting TOP1/2, thereby generating ge
Externí odkaz:
https://doaj.org/article/9bdee317ac4d4203b3c915708f13d271
Autor:
Haojie Yu, Hong Hwa Lim, Natalia O. Tjokro, Padmapriya Sathiyanathan, Suchitra Natarajan, Tian Wei Chew, Thomas Klonisch, Steven D. Goodman, Uttam Surana, Peter Dröge
Publikováno v:
Cell Reports, Vol 6, Iss 4, Pp 684-697 (2014)
Maintaining genome integrity requires the accurate and complete replication of chromosomal DNA. This is of the utmost importance for embryonic stem cells (ESCs), which differentiate into cells of all lineages, including germ cells. However, endogenou
Externí odkaz:
https://doaj.org/article/e0c0f79bc2d94e02a34db0d3f595b528
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 3, Pp 263-280 (2013)
The non-histone chromatin binding protein high mobility group AT-hook 2 (HMGA2) is expressed in stem cells and many cancer cells, including tumor initiating cells, but not translated in normal human somatic cells. The presence of HMGA2 is correlated
Externí odkaz:
https://doaj.org/article/62586f3145c54883b7e828c550abfd08
Autor:
Jia Wei Siau, Asim Azhar Siddiqui, Sze Yi Lau, Srinivasaraghavan Kannan, Sabrina Peter, Yingying Zeng, Chandra Verma, Peter Droge, John F. Ghadessy
Publikováno v:
PLoS ONE, Vol 19, Iss 2 (2024)
Externí odkaz:
https://doaj.org/article/a8102e41f4cd4c198dc89e84d4769ffd
Autor:
Frances Karla Kusuma, Aishvaryaa Prabhu, Galen Tieo, Syed Moiz Ahmed, Pushkar Dakle, Wai Khang Yong, Elina Pathak, Vikas Madan, Yan Yi Jiang, Wai Leong Tam, Dennis Kappei, Peter Dröge, H. Phillip Koeffler, Maya Jeitany
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
The kinase inhibitor Ponatinib inhibits an ABL1-JUN signalling axis and alters telomere homeostasis, reduces telomere synthesis, and provokes telomere dysfunction in cancer cells which employ the alternative lengthening of telomeres mechanisms.
Externí odkaz:
https://doaj.org/article/bc2741f3057b451aadd3c9a301ac079d
Autor:
Asim Azhar Siddiqui, Sabrina Peter, Eve Zi Xian Ngoh, Cheng-I. Wang, Shirelle Ng, John A. Dangerfield, Walter H. Gunzburg, Peter Dröge, Harshyaa Makhija
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Reliable cell-based platforms to test and/or produce biologics in a sustainable manner are important for the biotech industry. Utilizing enhanced λ integrase, a sequence-specific DNA recombinase, we developed a novel transgenesis platform involving
Externí odkaz:
https://doaj.org/article/7d08271bf26747a0830e808c29952bae
Autor:
Ruijie Zhou, Peter Droge
Publikováno v:
Current Genomics. 7:427-433
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45174fd73746b180381b647172fa694d
https://doi.org/10.2174/138920206779116774
https://doi.org/10.2174/138920206779116774
Autor:
Peter Droge.
Integration host factor (IHF) is a heterodimeric Escherichia coli protein that plays important roles in a variety of cellular processes including site-specific recombination, transcription, replication, and DNA compaction (reviewed in 1,2). IHF exert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1392::0545e469101d798dae228026d430e0a9
http://hdl.handle.net/10356/14568
http://hdl.handle.net/10356/14568
Publikováno v:
PLoS ONE, Vol 17, Iss 9, p e0270173 (2022)
Seamless DNA vectors derived from bacterial plasmids are devoid of bacterial genetic elements and represent attractive alternatives for biomedical applications including DNA vaccines. Larger scale production of seamless vectors employs engineered Esc
Externí odkaz:
https://doaj.org/article/b600a7576a224fccab2d36a8041bba7e