Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Peter Droescher"'
1
Structure-based design, synthesis and in vitro characterization of potent 17β-hydroxysteroid dehydrogenase type 1 inhibitors based on 2-substitutions of estrone and D-homo-estrone
Autor: Dorota Kowalik, Walter Elger, Andrea Rosinus, Dominga Deluca, Gabriele Möller, Peter Droescher, Christian Gege, Alexander Hillisch, Olaf Peters, Jerzy Adamski
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:6740-6744
In search for specific drugs against steroid-dependent cancers we have developed a novel set of potent inhibitors of steroidogenic human 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD 1). The X-ray structure of 17beta-HSD 1 in complex with es
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c99dcb529fa4520d03d3fe159135b60
https://doi.org/10.1016/j.bmcl.2009.09.113
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2
The significance of the 20-carbonyl group of progesterone in steroid receptor binding: a molecular dynamics and structure-based ligand design study
Autor: Birgitt Schneider, Bernd Menzenbach, Peter Droescher, Alexander Hillisch, Walter Elger, Johannes von Langen, Günter Kaufmann
Publikováno v: Steroids. 68:869-878
Polar functional groups in the A- and D-ring (positions 3 and 17beta or 20) are common to all natural and synthetic steroid hormones. It was assumed that these pharmacophoric groups are involved in strong hydrogen bonding interactions with the respec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7d2e83927e85215790dcf70ad985a5
https://doi.org/10.1016/j.steroids.2003.08.009
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4
Novel estrogens and their radical scavenging effects, iron-chelating, and total antioxidative activities: 17α-substituted analogs of Δ9(11)-dehydro-17β-estradiol
Autor: Sigfrid Schwarz, Peter Droescher, Michael Oettel, Bernd Menzenbach, Wolfgang Römer
Publikováno v: Steroids. 62:688-694
Antioxidant effects of N,N-dimethyl-p-toluidine, p-cresol, and p-(hydroxy)thioanisol 17 alpha-substituted analogs of 17 beta-estradiol and their delta 9(11)-dehydro homologs were investigated using four different in vitro models: rat synaptosomal lip
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e5914ef40126d06243ec9f0bd052c3
https://doi.org/10.1016/s0039-128x(97)00068-8
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5
A novel synthesis of 14α, 15α-methylene estradiol (J 824)
Autor: Hans-J. Siemann, Sigfrid Schwartz, Peter Droescher, Undeutsch B
Publikováno v: Steroids. 60:308-315
A novel approach to the synthesis of the orally active estrogen 14α, 15α-methylene estradiol (8, J 824) is described, starting with 3-methoxy-estra-1,3,5(10),8,14-pentaen-17α-ol(5). The 14α, 15α-methylene bridge was sonochemically introduced by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72ec604f932c851c9b38a7833dd9b0b9
https://doi.org/10.1016/0039-128x(94)00046-f
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6
A nickelacycle as propionic acid equivalent for carbon-carbon coupling reactions; application to the synthesis of C25 steroid carboxylic acids
Autor: Bernd Nestler, Reinald Fischer, Hermann Eibisch, Peter Droescher, Gabriele Bräunlich, Bruno Schönecker, Dirk Walther
Publikováno v: Tetrahedron Letters. 31:1257-1260
β-Substituted propionic acids are prepared in good yields by carbon-carbon coupling reaction of the nickelacycle 1 with organic iodides and anhydrous manganese(II) iodide. This new reaction is used to the synthesis of C25 steroid carboxylic acids fr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b8173f6655bac8aa2523f8e044ea2ed
https://doi.org/10.1016/s0040-4039(00)88779-1
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7
An Improved Synthesis of (24R)-24,25-Dihydroxyprovitamin D3 1
Autor: Eberhard Schrötter, Peter Droescher, Bruno Schönecker, Hans Schick, Ulrich Hauschild
Publikováno v: Synthesis. 1990:193-195
(24R)-24,25-Dihydroxyprovitamin D 3 was prepared in 33% overall yield by a six-tep procedure starting from the Diels-Alder adduct of ergosteryl benzoate and 1,4-dihydrophthalazine-1,4-dione. The yield thus obtained is more than four times as high as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a25baa4da98a5ecdb48db7cde626ccea
https://doi.org/10.1055/s-1990-26826
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8
Novel 'scavestrogens' and their radical scavenging effects, iron-chelating, and total antioxidative activities: delta 8,9-dehydro derivatives of 17 alpha-estradiol and 17 beta-estradiol
Autor: Wolfgang Römer, Sigfrid Schwarz, Peter Droescher, Michael Oettel
Publikováno v: Steroids. 62(3)
Antioxidant effects of delta 8,9-dehydro derivatives of 17 alpha-estradiol and 17 beta-estradiol were investigated using four different in vitro models: rat synaptosomal lipid peroxidation induced by Fenton's reagent, Fe(II)-chelating activities, the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5430513c400db81a932dbe68bbf92148
https://pubmed.ncbi.nlm.nih.gov/9071739
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