Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Peter Detloff"'
Autor:
Yun J. Kim, Ellen Sapp, Benjamin G. Cuiffo, Lindsay Sobin, Jennifer Yoder, Kimberly B. Kegel, Zheng-Hong Qin, Peter Detloff, Neil Aronin, Marian DiFiglia
Publikováno v:
Neurobiology of Disease, Vol 22, Iss 2, Pp 346-356 (2006)
N-terminal mutant huntingtin (N-mhtt) fragments form inclusions and cause cell death in vitro. Mutant htt expression stimulates autophagy and increases levels of lysosomal proteases. Here, we show that lysosomal proteases, cathepsins D, B and L, affe
Externí odkaz:
https://doaj.org/article/877e860b05cf4a09b15ee4ecb871b503
Publikováno v:
Molecular and Cellular Biology. 14:6936-6943
We describe a two-step strategy to alter any mouse locus repeatedly and efficiently by direct positive selection. Using conventional targeting for the first step, a functional neo gene and a nonfunctional HPRT minigene (the "socket") are introduced i
Publikováno v:
Nature Precedings
N-methyl-D-aspartate receptor (NMDAR) mediated excitotoxicity is implicated as a proximate cause of neurodegeneration in Huntington Disease (HD). However, this hypothesis has not been tested rigorously in vivo. NMDAR NR2B-subunits are the predominant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______984::b25afc337f66f8becda95b9ea10ec998
http://precedings.nature.com/documents/1996/version/1
http://precedings.nature.com/documents/1996/version/1
Publikováno v:
Current genetics. 21(2)
Several investigators have reported that transcription stimulates some types of mitotic recombination in the yeast Saccharomyces cerevisiae. We find that mutations that reduce the rate of transcription of the yeast HIS4 gene in vegetative cells reduc
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 88(21)
In the yeast Saccharomyces cerevisiae, as in other eukaryotes, some regions of the genome have a much higher rate of meiotic recombination than others. We show below that the binding of the RAP1 protein to a site upstream of the HIS4 gene is necessar
Heteroduplexes formed between DNA strands derived from different homologous chromosomes are an intermediate in meiotic crossing over in the yeast Saccharomyces cerevisiae and other eucaryotes. A heteroduplex formed between wild-type and mutant genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539f8da93eda22b490aa89ad66f76049
Autor:
Thomas D. Petes, S. R. Judd, Martin Kupiec, L. S. Symington, Ann E. Stapleton, Sue Jinks-Robertson, Dilipk . Nag, A. Vincent, Michael A. White, Peter Detloff
Publikováno v:
Genome. 31(2)
The development of methods to isolate eukaryotic genes, alter these genes in vitro and reintroduce them into the cell has had a major impact on the study of recombination in the yeast Saccharomyces cerevisiae. In this paper we discuss how recombinant
Autor:
Ghavami, Afshin1 (AUTHOR), Olsen, Michael1 (AUTHOR), Kwan, Mei1 (AUTHOR), Beltran, Jose1 (AUTHOR), Shea, John1 (AUTHOR), Ramboz, Sylvie1 (AUTHOR), Duan, Wenzhen2 (AUTHOR), Lavery, Daniel3 (AUTHOR), Howland, David3 (AUTHOR) david.howland@chdifoundation.org, Park, Larry C.3 (AUTHOR)
Publikováno v:
Journal of Huntington's Disease. 2020, Vol. 9 Issue 1, p13-31. 19p.
Autor:
Young, Douglas1, Mayer, Franziska1, Vidotto, Nella1, Schweizer, Tatjana1, Berth, Ramon1, Abramowski, Dorothee1, Shimshek, Derya R.1, van der Putten, P. Herman1 derya.shimshek@novartis.com, Schmid, Peter1 PeSchmid@aol.com
Publikováno v:
PLoS ONE. Sep2013, Vol. 8 Issue 9, p1-10. 10p.
Autor:
Titus, Anto Sam Crosslee Louis Sam, Yusuff, Tanzeen, Cassar, Marlène, Thomas, Elizabeth, Kretzschmar, Doris, D'Mello, Santosh R.
Publikováno v:
Journal of Neuroscience; 7/5/2017, Vol. 37 Issue 27, p6575-6587, 13p