Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Peter D. Williams"'
Autor:
Raymond Nowak, Frédéric Lévy, Elodie Chaillou, Fabien Cornilleau, Juliette Cognié, Pierre-Guy Marnet, Peter D. Williams, Matthieu Keller
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2021)
The neuropeptide oxytocin (OT) promotes maternal care and social affiliation in adults but its importance in infant attachment still remains unknown. True animal models of infant attachment are extremely rare, and the sheep (in complement to non-huma
Externí odkaz:
https://doaj.org/article/a68d8765f76c4e28bc5c399c02e6eece
Autor:
Carolyn Bahnck-Teets, Xu Min, Lehua Chang, Tracy L. Diamond, M. Katharine Holloway, John F. Fay, David Jonathan Bennett, John A. Mccauley, Jurgen Schulz, Marie Loughran, Peter D. Williams, Alejandro Crespo, Andrew Stamford, Hua-Poo Su, Michael D. Miller, Kartik M. Keertikar, Christopher J. Bungard, Catherine M. Wiscount, Bin Zhong, Jeanine E. Ballard, Sherman T. Waddell, Steven S. Carroll, Tao Ji, Jesse J. Manikowski, Bin Hu, Xin-jie Chu, Gregori J. Morriello, William J. Morris, Michael P. Dwyer
Publikováno v:
ACS Medicinal Chemistry Letters. 8:1292-1297
Using the HIV-1 protease binding mode of MK-8718 and PL-100 as inspiration, a novel aspartate binding bicyclic piperazine sulfonamide core was designed and synthesized. The resulting HIV-1 protease inhibitor containing this core showed an 60-fold inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6240d0128d9c35a558caa2cfbba15fa5
https://doi.org/10.1021/acsmedchemlett.7b00386
https://doi.org/10.1021/acsmedchemlett.7b00386
Autor:
Christopher J. Winrow, John J. Renger, Craig A. Stump, Tamara D. Cabalu, Terrence P. McDonald, C. Meacham Harell, Scott D. Kuduk, Anthony L. Gotter, Julie A. O'Brien, Cooke Andrew John, Paul J. Coleman, Peter D. Williams, Joseph G. Bruno
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(23)
While a correlation between blockade of the orexin 2 receptor (OX2R) with either a dual orexin receptor antagonist (DORA) or a selective orexin 2 receptor antagonist (2-SORA) and a decrease of wakefulness is well established, less is known about sele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27663ab0b0c341d4ece92fdca73f2a52
https://pubmed.ncbi.nlm.nih.gov/27818110
https://pubmed.ncbi.nlm.nih.gov/27818110
Autor:
Li Hao, Carolyn Bahnck-Teets, Catherine M. Wiscount, Daniel J. McKay, Carmela Molinaro, Ronald K. Chang, S S Carroll, Sivalenka Vijayasaradhi, Philippe G. Nantermet, Sanjay Kumar Singh, Christopher J. Bungard, Dubost David C, David Jonathan Bennett, Thomas J. Greshock, Hua-Poo Su, Rosa I. Sanchez, Vouy Linh Truong, Xu Min, John F. Fay, Jeanine E. Ballard, John A. McCauley, Christian Beaulieu, M. Katharine Holloway, Joseph P. Vacca, Michael W. Miller, Tummanapalli Satyanarayana, Sheldon Crane, William D. Shipe, Jesse J. Manikowski, Peter D. Williams, Christian Nadeau, Jennifer J. Gesell, Tracy L. Diamond, Peter J. Felock, Oscar Miguel Moradei
A novel HIV protease inhibitor was designed using a morpholine core as the aspartate binding group. Analysis of the crystal structure of the initial lead bound to HIV protease enabled optimization of enzyme potency and antiviral activity. This afford
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f685aed82b9b428b5b9e7330d8f427
https://europepmc.org/articles/PMC4948015/
https://europepmc.org/articles/PMC4948015/
Autor:
Michael D. Miller, Ye Mei, Marie H. Loughran, Jay A. Grobler, Winnie Ngo, Meiqing Lu, Vandna Munshi, Peter D. Williams, Tracy L. Diamond, Daria J. Hazuda, Ming-Tain Lai, Christine Burlein
Publikováno v:
Protein Expression and Purification. 71:231-239
Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) plays an essential role in the life cycle of the virus. Therefore, RT has been a primary target in the development of antiviral agents against HIV-1. Given the prevalence of resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c474d787ddd4971895efd8b11c225e6
https://doi.org/10.1016/j.pep.2010.01.001
https://doi.org/10.1016/j.pep.2010.01.001
Autor:
Peter D. Williams, Emanuel Kopp
Publikováno v:
IMF Working Papers. 18:1
In recent years, term premia have been very low and sometimes even negative. Now, with the United States economy growing above potential, inflationary pressures are on the rise. Term premia are very sensitive to the expected future path of growth, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543a0eddc054a3c71a113192e1bca4ee
https://doi.org/10.5089/9781484362150.001
https://doi.org/10.5089/9781484362150.001
Autor:
Joseph P. Vacca, Linghang Zhuang, Lori J. Gabryelski, Terry A. Lyle, William A. Schleif, Peter J. Felock, Boyoung Kim, Lixia Jin, I.-W. Chen, Donnette D. Staas, Chris Culberson, Steven D. Young, Daria J. Hazuda, Thorsten E. Fisher, John S. Wai, Peter D. Williams, Mark Embrey, Rama Mallai, Joan D. Ellis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5595-5599
A series of potent novel dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors was identified. These compounds inhibited the strand transfer process of HIV-1 integrase and viral replication in cells. Compound 6 is active against replication of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c7dd8e0e282073e0fa1b3f0f4f284ae
https://doi.org/10.1016/j.bmcl.2007.07.092
https://doi.org/10.1016/j.bmcl.2007.07.092
Autor:
Vanessa L. Sherman, M. Reza Anari, Catherine M. Wiscount, Julie A. Krueger, Christopher J. Kochansky, Bobby J. Lucas, Tran Lekhanh O, Joseph P. Vacca, Terry A. Lyle, Bradley K. Wong, Sanderson Philip E, Heidi L. Shimp, Peter D. Williams, Sean Yu, Donnette D. Staas, Kelly L. Savage, S. Dale Lewis, Rebecca B. White, Youwei Yan, Daniel R. McMasters
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:6900-6916
Previous reports from our laboratories described potent tripeptide thrombin inhibitors which incorporate heterocycle-substituted chlorophenyl groups in the P1 position. Using these as lead compounds for further optimization, we identified sites of me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0f376b03a161dd0c0e74d58d1df6a5
https://doi.org/10.1016/j.bmc.2006.06.040
https://doi.org/10.1016/j.bmc.2006.06.040
Autor:
James Z. Deng, S. D. Lewis, P.M. Rabbat, Craig A. Coburn, Terry A. Lyle, J. P. Vacca, Bobby J. Lucas, Daniel R. McMasters, Julie A. Krueger, B. Strulovici, Youwei Yan, Peter D. Williams, Lawrence Kuo, Christopher S. Burgey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4411-4416
Thrombin-inhibitor X-ray crystal structures, in combination with the installation of binding elements optimized within the pyrazinone series of thrombin inhibitors, were utilized to transform a weak triazolopyrimidine lead into a series of potent oxa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1043fcace9743b215fcb917a262ed643
https://doi.org/10.1016/j.bmcl.2005.07.022
https://doi.org/10.1016/j.bmcl.2005.07.022
Autor:
Rebecca B. White, Bradley K. Wong, Elizabeth A. Lyle, K.J. Stauffer, Matthew M. Morrissette, S. Dale Lewis, Joseph P. Vacca, Yvonne M. Leonard, Cynthia Miller-Stein, Audrey A. Wallace, Bobby J. Lucas, Daniel R. McMasters, Julie A. Krueger, Joseph J. Lynch, Terry A. Lyle, Denise C. Welsh, Peter D. Williams
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4161-4164
Modification of lead compound 1 by reducing lipophilicity in the P3 group produced a series of low molecular weight thrombin inhibitors with excellent potency in functional assays, metabolic stability, and oral bioavailability. These modifications le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6c0d71034ff41d4256b917aa2cedfc
https://doi.org/10.1016/j.bmcl.2004.06.030
https://doi.org/10.1016/j.bmcl.2004.06.030