Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Peter D. Sun"'
Autor:
Joanna Ireland, Jason Segura, Genbin Shi, Julianna Buchwald, Gwynne Roth, Thomas Juncheng Shen, Ruipeng Wang, Xinhua Ji, Elizabeth R. Fischer, Susan Moir, Tae-Wook Chun, Peter D. Sun
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
HIV-1 gp120 glycan binding to C-type lectin adhesion receptor L-selectin/CD62L on CD4 T cells facilitates viral attachment and entry. Paradoxically, the adhesion receptor impedes HIV-1 budding from infected T cells and the viral release requires the
Externí odkaz:
https://doaj.org/article/d1345b938a9e4d4b9d8558446242fdc7
Autor:
Rachel Erickson, Chang Huang, Cameron Allen, Joanna Ireland, Gwynne Roth, Zhongcheng Zou, Jinghua Lu, Bernard A. P. Lafont, Nicole L. Garza, Beniah Brumbaugh, Ming Zhao, Motoshi Suzuki, Lisa Olano, Joseph Brzostowski, Elizabeth R. Fischer, Homer L. Twigg, Reed F. Johnson, Peter D. Sun
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Severe COVID-associated lung injury is a major confounding factor of hospitalizations and death with no effective treatments. Here, we describe a non-classical fibrin clotting mechanism mediated by SARS-CoV-2 infected primary lung but not ot
Externí odkaz:
https://doaj.org/article/dfb1e8c9aa3047e59958ec0f9d7a69ea
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Understanding the molecular mechanism underlying the hierarchic binding between FcγRs and IgG antibodies is critical for therapeutic antibody engineering and FcγR functions. The recent determination of crystal structures of FcγRI-Fc complexes, how
Externí odkaz:
https://doaj.org/article/acd1d13f3df64530a0d310ed2e95b81d
Publikováno v:
PLoS ONE, Vol 18, Iss 9 (2023)
Externí odkaz:
https://doaj.org/article/d29e1779a33e4084a16f336f9504aab1
Autor:
Jason Segura, Joanna Ireland, Zhongcheng Zou, Gwynne Roth, Julianna Buchwald, Thomas J. Shen, Elizabeth Fischer, Susan Moir, Tae-Wook Chun, Peter D. Sun
Publikováno v:
PLoS ONE, Vol 18, Iss 2 (2023)
HIV infection remains incurable to date and there are no compounds targeted at the viral release. We show here HIV viral release is not spontaneous, rather requires caspases activation and shedding of its adhesion receptor, CD62L. Blocking the caspas
Externí odkaz:
https://doaj.org/article/6e02b248161e4e1cbc04ce971cdb2f04
Autor:
François Van Laethem, Abhisek Bhattacharya, Marco Craveiro, Jinghua Lu, Peter D. Sun, Alfred Singer
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Understanding the generation of an MHC-restricted T cell repertoire is the cornerstone of modern T cell immunology. The unique ability of αβT cells to only recognize peptide antigens presented by MHC molecules but not conformational antigens is ref
Externí odkaz:
https://doaj.org/article/76e87e0eec1242be99fc58fb598e83f1
Autor:
Malcolm J. W. Sim, Peter D. Sun
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In cancer, non-synonymous DNA base changes alter protein sequence and produce neoantigens that are detected by the immune system. For immune detection, neoantigens must first be presented on class I or II human leukocyte antigens (HLA) followed by re
Externí odkaz:
https://doaj.org/article/bfb13742b2ad4c60862c0d6e150c8588
Autor:
Jason Segura, Biao He, Joanna Ireland, Zhongcheng Zou, Thomas Shen, Gwynne Roth, Peter D. Sun
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
HIV envelope glycoprotein is the most heavily glycosylated viral protein complex identified with over 20 glycans on its surface. This glycan canopy is thought to primarily shield the virus from host immune recognition as glycans are poor immunogens i
Externí odkaz:
https://doaj.org/article/0f1f411fe52949b2bc8c18611a1edc13
Autor:
Jinghua Lu, François Van Laethem, Abhisek Bhattacharya, Marco Craveiro, Ingrid Saba, Jonathan Chu, Nicholas C. Love, Anastasia Tikhonova, Sergei Radaev, Xiaoping Sun, Annette Ko, Tomer Arnon, Eric Shifrut, Nir Friedman, Nan-Ping Weng, Alfred Singer, Peter D. Sun
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
For T cells, functional antigen receptors are selected in the thymus from a pre-selection repertoire by interaction with self MHCs. Here the authors show that specific, non-germline coded features located in the complementarity determining region 3 o
Externí odkaz:
https://doaj.org/article/2135b8948a994dbda344f75d21b684fb
Autor:
François Van Laethem, Ingrid Saba, Jinghua Lu, Abhisek Bhattacharya, Xuguang Tai, Terry I. Guinter, Britta Engelhardt, Amala Alag, Mirelle Rojano, Jennifer M. Ashe, Ken-ichi Hanada, James C. Yang, Peter D. Sun, Alfred Singer
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins. Although naturally generated in the thymus, these TCRs resemble re-engineered therapeutic ch
Externí odkaz:
https://doaj.org/article/8782eccbbb154dcb86bc5b3f712336d7