Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Peter D. J. Grootenhuis"'
Autor:
Jutta Glock, Peter D. J. Grootenhuis, Steven Bondy, Daniel D. Comer, Soan Cheng, Arthur Steiger, Martin Zeller, Grit Laue, Adrian Friedmann, Olivier Jacob, Mafalda Nina, Hans-Jürg Widmer, Klaus Kreuz, Julie E. Penzotti, Hans Brunner, James Allen, Thierry Niderman, Hans Ulrich Haas, Renold Chollet, Martin Eberle, Peter Renold, William Lutz, Jürg Ehrler, Marian Valentini, Markus Walti, Evelyne Sieger, Thomas Vettiger, G. Wayne Craig
Publikováno v:
CHIMIA, Vol 62, Iss 1-2 (2008)
The search for new active molecules with novel modes of action and desirable physical properties is an ongoing endeavour. This publication describes the follow-up chemistry of a biological hit discovered in the screening system of Novartis Crop Prote
Externí odkaz:
https://doaj.org/article/5c120d9f6ae7458abd6d1d641fce6442
Publikováno v:
2018 Medicinal Chemistry Reviews ISBN: 9780996293266
2018 Medicinal Chemistry Reviews
2018 Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::deee7cefe7ba8d46db26c255719b5c87
https://doi.org/10.29200/acsmedchemrev-v53.ch25
https://doi.org/10.29200/acsmedchemrev-v53.ch25
Autor:
Jan N. M. Commandeur, Daan P. Geerke, Flemming Jørgensen, Ernst ter Haar, Arun K. Mohanty, Lars Olsen, Luigi Capoferri, Rasmus Leth, Peter D. J. Grootenhuis, Eduardo Vottero, Nico P. E. Vermeulen
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 84:383-396
Cytochrome P450 BM3 (CYP102A1) mutant M11 is able to metabolize a wide range of drugs and drug-like compounds. Among these, M11 was recently found to be able to catalyze formation of human metabolites of mefenamic acid and other nonsteroidal anti-inf
Autor:
John Saunders, Jan N. M. Commandeur, Peter D. J. Grootenhuis, Nico P. E. Vermeulen, Jelle Reinen, Caroline Decker, Yongmin Li, Jolanda van Leeuwen, Lifang Sun
Publikováno v:
Drug Metabolism and Disposition. 39:1568-1576
In the present study, the diversity of a library of drug-metabolizing bacterial cytochrome P450 (P450) BM3 mutants was evaluated by a liquid chromatography-mass spectrometry (LC-MS)-based screening method. A strategy was designed to identify a minima
Publikováno v:
Recueil des Travaux Chimiques des Pays-Bas. 112:161-168
The present paper evaluates the effect of several parameters on the accuracy of homology model-built structures of human thrombin. In order to appraise the merits of such a homology model-building study as a practical basis for direct drug-design pur
Autor:
Luigi, Capoferri, Rasmus, Leth, Ernst, ter Haar, Arun K, Mohanty, Peter D J, Grootenhuis, Eduardo, Vottero, Jan N M, Commandeur, Nico P E, Vermeulen, Flemming Steen, Jørgensen, Lars, Olsen, Daan P, Geerke
Publikováno v:
Proteins. 84(3)
Cytochrome P450 BM3 (CYP102A1) mutant M11 is able to metabolize a wide range of drugs and drug-like compounds. Among these, M11 was recently found to be able to catalyze formation of human metabolites of mefenamic acid and other nonsteroidal anti-inf
Autor:
Tom Knapp, Victor Panchenko, Paul A. Negulescu, Ashvani K. Singh, Roger D. Tung, James A. Rader, Timothy Neuberger, Fredrick Van Goor, Kimberly Straley, Jeffrey H. Stack, Jesus E. Gonzalez, Eric R. Olson, John Joubran, Dong Cao, Mark Miller, Peter D. J. Grootenhuis, Sabine Hadida, Anna R. Hazlewood, Lewis R. Makings
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 290:L1117-L1130
Cystic fibrosis (CF) is a fatal genetic disease caused by mutations in cftr, a gene encoding a PKA-regulated Cl−channel. The most common mutation results in a deletion of phenylalanine at position 508 (ΔF508-CFTR) that impairs protein folding, tra
Autor:
Mccartney Jason, Vijayalaksmi Arumugam, Peter D. J. Grootenhuis, Sabine Hadida, Caroline Decker, Paul A. Negulescu, Anna R. Hazlewood, Fredrick Van Goor, Jinglan Zhou
Publikováno v:
Journal of medicinal chemistry. 57(23)
Quinolinone-3-carboxamide 1, a novel CFTR potentiator, was discovered using high-throughput screening in NIH-3T3 cells expressing the F508del-CFTR mutation. Extensive medicinal chemistry and iterative structure–activity relationship (SAR) studies t
Publikováno v:
Drug Discovery Today: Technologies. 1:381-387
Predictive models for drug safety are crucial for helping to avoid costly late-stage failures. We review recent work on models for genotoxicity, liver toxicity, CYP450 inhibition and cardiotoxicity. These models have improved somewhat in recent years
Autor:
Angelo J. Castellino, Peter D. J. Grootenhuis, Bondy Steven Scott, Mark J. Suto, Erin K. Bradley, Graham Beaton, Paul A. Gibbons, Michelle Lamb
Publikováno v:
Journal of Molecular Graphics and Modelling, 23(1), 15-21. Elsevier Inc.
Lamb, M L, Bradley, E K, Beaton, G, Bondy, S S, Castellino, A J, Gibbons, P A, Suto, M J & Grootenhuis, P D J 2004, ' Design of a gene family screening library targeting G-protein coupled receptors ', Journal of Molecular Graphics and Modelling, vol. 23, no. 1, pp. 15-21 . https://doi.org/10.1016/j.jmgm.2004.03.001
Lamb, M L, Bradley, E K, Beaton, G, Bondy, S S, Castellino, A J, Gibbons, P A, Suto, M J & Grootenhuis, P D J 2004, ' Design of a gene family screening library targeting G-protein coupled receptors ', Journal of Molecular Graphics and Modelling, vol. 23, no. 1, pp. 15-21 . https://doi.org/10.1016/j.jmgm.2004.03.001
An iterative process for the design of a G-protein coupled receptor (GPCR) gene family screening library has been developed. A key element of this process is the computational generation of pharmacophore descriptors of known GPCR ligands. Subsequent