Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Peter D. Beitsch"'
Autor:
Mi Jeong Kwon, Sae Byul Lee, Jinil Han, Jeong Eon Lee, Jong Won Lee, Gyungyub Gong, Peter D Beitsch, Seok Jin Nam, Sei Hyun Ahn, Byung-Ho Nam, Young Kee Shin
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207155 (2018)
The Breast Cancer Test (BCT) score has been validated for its ability to predict the risk of distant metastasis in hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative early breast cancer. This study aimed to examine th
Externí odkaz:
https://doaj.org/article/598981f0399b476082fb17b5dbbf71ec
Autor:
Pat W. Whitworth, Peter D. Beitsch, Mary K. Murray, Paul D. Richards, Angela Mislowsky, Carrie L. Dul, James V. Pellicane, Paul L. Baron, Rakhshanda Layeequr Rahman, Laura A. Lee, Beth B. Dupree, Pond R. Kelemen, Andrew Y. Ashikari, Raye J. Budway, Cristina Lopez-Penalver, William Dooley, Shiyu Wang, Patricia Dauer, Andrea R. Menicucci, Erin B. Yoder, Christine Finn, Lisa E. Blumencranz, William Audeh
Publikováno v:
JCO precision oncology. 6
PURPOSE The prospective Neoadjuvant Breast Registry Symphony Trial compared the 80-gene molecular subtyping signature with clinical assessment by immunohistochemistry and/or fluorescence in situ hybridization in predicting pathologic complete respons
Autor:
James V. Pellicane, Peter D. Beitsch, David T. Rock, Raye J. Budway, Carrie L. Dul, Pond R. Kelemen, Andrew Y. Ashikari, Paul L. Baron, Paul D. Weinstein, Angela Mislowsky, Laura A. Lee, Jennifer Beatty, Mary K. Murray, Beth B. Dupree, Christine Finn, Kate Corcoran, Shiyu Wang, Andrea R. Menicucci, Erin B. Yoder, Lisa E. Blumencranz, Patricia Dauer, William Audeh, Pat W. Whitworth
Publikováno v:
Surgical oncology. 45
As more patients with early-stage breast cancer receive neoadjuvant endocrine therapy (NET), there is a need for reliable biomarkers that can identify patients with HR+ HER2- tumors who are likely to benefit from NET. NBRST (NCT01479101) compared the
Abstract PS8-30: Longitudinal clinical outcomes of a multi-center universal genetic testing registry
Autor:
Melissa Trudrung, Max Brown, Ian Grady, Barry P. Rosen, Mary Kay Hardwick, Rakesh Patel, Edward D. Esplin, Sarah M. Nielsen, Chloe Wernecke, Gia Compagnoni, Linsey Gold, Robert L. Nussbaum, Peter D. Beitsch, Richard J. C. Brown, Pat Whitworth
Publikováno v:
Cancer Research. 81:PS8-30
Background: Growing evidence indicates that restrictive criteria for determining eligibility of breast cancer patients for germline genetic testing (e.g. NCCN, etc.) can missa significant number who may benefit from testing. However, the clinical uti
Autor:
Sarah M. Nielsen, Natalie Rickers, Emily Decker, Peter D. Beitsch, Hana Sroka, Ed D. Esplin, Robert L. Nussbaum, Alekhya Narravula, Pat Whitworth
Publikováno v:
Cancer Research. 81:PS8-14
Background:Therapeutic and risk management options have expanded for patients harboring pathogenic variants (PVs) in cancer predisposition genes. Historically, testing costs and clinical implementation challenges led to restrictive testing guidelines
Autor:
Pat W, Whitworth, Peter D, Beitsch, James V, Pellicane, Paul L, Baron, Laura A, Lee, Carrie L, Dul, Mary K, Murray, Mark A, Gittleman, Raye J, Budway, Rakhshanda Layeequr, Rahman, Pond R, Kelemen, William C, Dooley, David T, Rock, Kenneth H, Cowan, Beth-Ann, Lesnikoski, Julie L, Barone, Andrew Y, Ashikari, Beth B, Dupree, Shiyu, Wang, Andrea R, Menicucci, Erin B, Yoder, Christine, Finn, Kate, Corcoran, Lisa E, Blumencranz, William, Audeh
Publikováno v:
JCO Precision Oncology.
PURPOSE The 80-gene molecular subtyping signature (80-GS) reclassifies a proportion of immunohistochemistry (IHC)-defined luminal breast cancers (estrogen receptor–positive [ER+], human epidermal growth factor receptor 2–negative [HER2–]) as Ba
Autor:
Lynne Clark, Barbara L. Smith, Stephen E. Karp, Katherine Clegg Smith, Irene Wapnir, Sean Madden, Peter D. Beitsch, Stephanie A. Valente, W. David Lee, Donna Lynn Dyess, Nayana Dekhne, Beth-Ann Lesnikoski, Jorge Ferrer, Anees B. Chagpar, Peter W. Blumencranz, Kelly K. Hunt, David Carr, Brian Schlossberg, S Hwang, Linsey Gold, Daleela Dodge, Manna Chang, David B. Strasfeld
Publikováno v:
Cancer Research. 80:P1-20
Background: Standard surgical techniques result in positive lumpectomy margins 20-40% of the time. These positive margins require surgical re-excision which places significant burden on the healthcare system and patients. The LUM Imaging System consi
Autor:
Antonio Carlos Sánchez Ruiz, Laura Lee, Linsey Gold, Rakesh Patel, Paul L. Baron, Peter D. Beitsch, Pat Whitworth, Richard J. C. Brown
Publikováno v:
Cancer Research. 80:P2-16
Background: Molecular genomic profiles are increasingly used to guide treatment of refractory cancers and are on the forefront of personalized medicine for select patients. The neoadjuvant chemotherapy (NAC) setting provides a meaningful opportunity
Autor:
Pat, Whitworth, Peter D, Beitsch, James V, Pellicane, Paul L, Baron, Laura A, Lee, Carrie L, Dul, Charles H, Nash, Mary K, Murray, Paul D, Richards, Mark, Gittleman, Raye, Budway, Rakhshanda Layeequr, Rahman, Pond, Kelemen, William C, Dooley, David T, Rock, Ken, Cowan, Beth-Ann, Lesnikoski, Julie L, Barone, Andrew Y, Ashikari, Beth, Dupree, Shiyu, Wang, Andrea R, Menicucci, Erin B, Yoder, Christine, Finn, Kate, Corcoran, Lisa E, Blumencranz, William, Audeh
Publikováno v:
Annals of surgical oncology.
The Neoadjuvant Breast Symphony Trial (NBRST) demonstrated the 70-gene risk of distant recurrence signature, MammaPrint, and the 80-gene molecular subtyping signature, BluePrint, precisely determined preoperative pathological complete response (pCR)
Autor:
Pat W, Whitworth, Peter D, Beitsch, Rakesh, Patel, Barry, Rosen, Gia, Compagnoni, Paul L, Baron, Rache, Simmons, Eric A, Brown, Linsey, Gold, Dennis, Holmes, Linda Ann, Smith, Michael, Kinney, Ian, Grady, Patricia, Clark, Karen, Barbosa, Samuel, Lyons, Lee, Riley, Cynara, Coomer, Lisa, Curcio, Antonio, Ruiz, Sadia, Khan, Heather, MacDonald, Kevin, Hughes, Mary Kay, Hardwick, Brandie, Heald, Sandra B, Munro, Sarah M, Nielsen, Edward D, Esplin
Publikováno v:
JAMA Network Open. 5:e2232787
ImportanceNational Comprehensive Cancer Network guidelines currently recommend germline testing for high-risk genes in selected patients with breast cancer. The clinical utility of recommending testing all patients with breast cancer with multigene p