Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Peter D. Humphreys"'
Autor:
Hugh J. Willison, Jaap J. Plomp, Bart C. Jacobs, Jan J.G.M. Verschuuren, Kay N. Greenshields, Peter D. Humphreys, Femke M.P. Zitman, Russell P. Rother, Susan K. Halstead
Publikováno v:
Brain, 131, 1197-1208. Oxford University Press
Anti-GQ1b ganglioside antibodies are the serological hallmark of the Miller Fisher syndrome (MFS) variant of the paralytic neuropathy, Guillain-Barré syndrome, and are believed to be the principal pathogenic mediators of the disease. In support of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3580f3509d8dba1d4927e78f9365e5b6
https://pure.eur.nl/en/publications/82f95fa3-8e9f-4556-9de7-4623af33b2e0
https://pure.eur.nl/en/publications/82f95fa3-8e9f-4556-9de7-4623af33b2e0
Autor:
Peter D. Humphreys, Hugh J. Willison, Eric R. Wagner, Richard A. G. Smith, Susan Halstead, John A. Goodfellow
Publikováno v:
Annals of Neurology. 58:203-210
A large body of clinical and experimental data indicate that complement activation is an important mechanism for neuronal and glial injury in Guillain-Barré syndromes. Inhibition of complement activation therefore might be expected to limit the prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b56d1bb2e3d91f29fc2096ac9b494b8
https://doi.org/10.1002/ana.20546
https://doi.org/10.1002/ana.20546
Autor:
Eric R. Wagner, Kazim A. Sheikh, Masaaki Odaka, Hugh J. Willison, Nobuhiro Yuki, Keiko Furukawa, Tyrone Bowes, Koichi Furukawa, John A. Goodfellow, Peter D. Humphreys, Jaap J. Plomp, Susan Halstead
Publikováno v:
The Journal of Neuroscience. 25:1620-1628
Anti-GD1a ganglioside antibodies (Abs) are the serological hallmark of the acute motor axonal form of the post-infectious paralysis, Guillain-Barré syndrome. Development of a disease model in mice has been impeded by the weak immunogenicity of gangl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::034c3eb9ba1c34c341e696378dee1f40
https://doi.org/10.1523/jneurosci.4279-04.2005
https://doi.org/10.1523/jneurosci.4279-04.2005
Autor:
Hugh J. Willison, Ian Morrison, John A. Goodfellow, Peter D. Humphreys, Graham M. O'Hanlon, Jaap J. Plomp, Susan Halstead
Publikováno v:
Glia. 52:177-189
The human paralytic neuropathy, Miller Fisher syndrome (MFS) is associated with autoantibodies specific for disialosyl epitopes on gangliosides GQ1b, GT1a, and GD3. Since these gangliosides are enriched in synaptic membranes, anti-ganglioside antibod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5f9b029e1bc02157962c4f08b5c7e9
https://doi.org/10.1002/glia.20228
https://doi.org/10.1002/glia.20228
Autor:
Andrew J. Todd, Jaap J. Plomp, Deborah Morrison, Graham M. O'Hanlon, Hugh J. Willison, Susan Halstead, Bryan Paul Morgan, Peter D. Humphreys
Publikováno v:
Brain. 127:2109-2123
Anti-disialoside antibodies (Abs) that bind NeuAc(alpha2-8) NeuAc epitopes on GQ1b and related gangliosides are found in human autoimmune neuropathy sera and are considered to be pathogenic. In a model system in mice, one mechanism by which anti-disi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca63085e7b82466849bd6b71f3aac8b
https://doi.org/10.1093/brain/awh231
https://doi.org/10.1093/brain/awh231
Anti-GD1a antibodies activate complement and calpain to injure distal motor nodes of Ranvier in mice
Autor:
Koichi Furukawa, Rhona McGonigal, Hugh J. Willison, Peter D. Humphreys, Susan K. Halstead, Russell P. Rother, Edward G. Rowan, Kay N. Greenshields
The motor axonal variant of Guillain-Barre syndrome is associated with anti-GD1a immunoglobulin antibodies, which are believed to be the pathogenic factor. In previous studies we have demonstrated the motor terminal to be a vulnerable site. Here we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00545d66e526ec6c502b03a25dbdabed
https://strathprints.strath.ac.uk/18561/842/strathprints018561.pdf
https://strathprints.strath.ac.uk/18561/842/strathprints018561.pdf
Autor:
Hugh J. Willison, John Hamer, Jaap J. Plomp, Susan K. Halstead, Peter D. Humphreys, Femke M.P. Zitman
Publikováno v:
Journal of the peripheral nervous system : JPNS. 13(3)
Guillain-Barre syndrome and its clinical variants, including the anti-GQ1b ganglioside-mediated Miller Fisher syndrome (MFS), comprise the world's leading cause of acute neuromuscular paralysis. Presently, no specific drug therapies exist. The comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa09673debf4b38c47ce9cbc0792e2fc
https://pubmed.ncbi.nlm.nih.gov/18844789
https://pubmed.ncbi.nlm.nih.gov/18844789
Autor:
Rebecca S. Goldman, Susan K. Halstead, Yuri A. Ushkaryov, Hugh J. Willison, Graham M. O'Hanlon, Jaap J. Plomp, Roland W. M. Bullens, Peter D. Humphreys
Publikováno v:
Brain : a journal of neurology. 126(Pt 11)
Miller Fisher syndrome-associated anti-GQ1b ganglioside antibodies produce an acute complement-dependent neuroexocytic effect at the mouse neuromuscular junction (NMJ) that closely resembles the effect of alpha-latrotoxin (LTx). This pathophysiologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5712ee0d451328dc7b8159cfdf3e1e
https://pubmed.ncbi.nlm.nih.gov/12937083
https://pubmed.ncbi.nlm.nih.gov/12937083
Autor:
Susan K. Halstead, Jaap J. Plomp, Femke M.P. Zitman, Hugh J. Willison, Kay N. Greenshields, Russell P. Rother, Peter D. Humphreys
Publikováno v:
Molecular Immunology. 44:3947
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::032984a7dcf8320fd84c857969d0aec4
https://doi.org/10.1016/j.molimm.2007.06.090
https://doi.org/10.1016/j.molimm.2007.06.090
Autor:
Susan K. Halstead, Peter D. Humphreys, John A. Goodfellow, Eric R. Wagner, Richard A. G. Smith, Hugh J. Willison
Publikováno v:
Annals of Neurology; Aug2005, Vol. 58 Issue 2, p203-210, 8p