Zobrazeno 1 - 10
of 319
pro vyhledávání: '"Peter D Clegg"'
Autor:
Danae E Zamboulis, Chavaunne T Thorpe, Yalda Ashraf Kharaz, Helen L Birch, Hazel RC Screen, Peter D Clegg
Publikováno v:
eLife, Vol 9 (2020)
Mature connective tissues demonstrate highly specialised properties, remarkably adapted to meet their functional requirements. Tissue adaptation to environmental cues can occur throughout life and poor adaptation commonly results in injury. However,
Externí odkaz:
https://doaj.org/article/f6c5f7b0a8534af78bbc9c4b1a971574
Autor:
Howard Choi, Deborah Simpson, Ding Wang, Mark Prescott, Andrew A Pitsillides, Jayesh Dudhia, Peter D Clegg, Peipei Ping, Chavaunne T Thorpe
Publikováno v:
eLife, Vol 9 (2020)
Maintenance of connective tissue integrity is fundamental to sustain function, requiring protein turnover to repair damaged tissue. However, connective tissue proteome dynamics remain largely undefined, as do differences in turnover rates of individu
Externí odkaz:
https://doaj.org/article/e8686602132243a49d5b937c44d9085a
Autor:
Katie J. Lee, Lisa Rambault, George Bou-Gharios, Peter D. Clegg, Riaz Akhtar, Gabriela Czanner, Rob van ‘t Hof, Elizabeth G. Canty-Laird
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 9 (2022)
Externí odkaz:
https://doaj.org/article/85128b1290fb417e9c2ede93c46f1d2d
Autor:
Panagiotis Balaskas, Katarzyna Goljanek-Whysall, Peter D. Clegg, Yongxiang Fang, Andy Cremers, Aibek Smagul, Tim J. M. Welting, Mandy J. Peffers
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1189 (2023)
Osteoarthritis is the most common degenerative joint disorder. MicroRNAs are gene expression regulators that act post-transcriptionally to control tissue homeostasis. Microarray analysis was undertaken in osteoarthritic intact, lesioned and young int
Externí odkaz:
https://doaj.org/article/1524c35eecee49269048b319151fb6a9
Autor:
Catarina I.G.D. Castanheira, James R. Anderson, Yongxiang Fang, Peter I. Milner, Katarzyna Goljanek-Whysall, Louise House, Peter D. Clegg, Mandy J. Peffers
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 3, Iss 4, Pp 100186- (2021)
Objective: This study investigated mice serum and joint microRNA expression profiles in ageing and osteoarthritis to elucidate the role of microRNAs in the development and progression of disease, and provide biomarkers for ageing and osteoarthritis.
Externí odkaz:
https://doaj.org/article/eda79792eccd45b3a2169d30b164d459
Publikováno v:
BMC Biotechnology, Vol 18, Iss 1, Pp 1-11 (2018)
Abstract Background The concept of tissue engineering is to deliver to the injury site biological scaffolds carrying functional cells that will enhance healing response. The preferred cell source is autologous in order to reduce immune response in th
Externí odkaz:
https://doaj.org/article/597075f43ef041d9af43dd0539056cbc
Publikováno v:
npj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-15 (2017)
Joint degeneration: linking animal and human disease Cartilage, and other tissues in our joints, begins to degenerate with age resulting in pain and reduced mobility; this is termed osteoarthritis (OA). To understand OA better researchers have often
Externí odkaz:
https://doaj.org/article/7cfff89113c548ac876d61f364504387
Autor:
Danae E. Zamboulis, Neil Marr, Luca Lenzi, Helen L. Birch, Hazel R. C. Screen, Peter D. Clegg, Chavaunne T. Thorpe
Energy storing tendons such as the human Achilles and equine superficial digital flexor tendon (SDFT) are prone to injury, with incidence increasing with ageing. The interfascicular matrix (IFM), which binds tendon fascicles, plays a key role in ener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e83b0ec93b9f4ce3b0a9f60a006ca1
https://doi.org/10.1101/2023.01.04.522701
https://doi.org/10.1101/2023.01.04.522701
Autor:
Dharmesh Patel, Helen L. Birch, Danae E Zamboulis, Hazel R. C. Screen, Chavaunne T. Thorpe, Peter D. Clegg, Ewa M. Spiesz
Publikováno v:
Acta Biomaterialia
ACTA BIOMATERIALIA
Acta Biomaterialia, 131
ACTA BIOMATERIALIA
Acta Biomaterialia, 131
Tendon consists of highly aligned collagen-rich fascicles surrounded by interfascicular matrix (IFM). Some tendons act as energy stores to improve locomotion efficiency, but such tendons commonly obtain debilitating injuries. In equine tendons, energ
Autor:
Nicholas C, Harvey, Peter D, Clegg, Elaine M, Dennison, Paul, Greenhaff, Simon J, Griffin, Celia L, Gregson, Malcom J, Jackson, Janet M, Lord, Eugene V, McCloskey, Emma, Stevenson, Jonathan H, Tobias, Kate A, Ward, Cyrus, Cooper, David, Wilkinson
Publikováno v:
Archives of osteoporosisReferences. 17(1)